Chelating Agents in the Therapy of Beryllium Poisoning

Cash, Ralph E.; Shapiro, Reuben I.; Levy, Stanley H.; Hopkins, Scovell M.

doi:10.1056/nejm195904022601402

Cited by 8 publications

(1 citation statement)

References 6 publications

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“…Much attention has been paid on detection and treatment of beryllium induced toxic manifestations using immunological variables but less work has been focused on chelation therapy accompanied by simultaneous recovery in altered biochemical and histopathological aspects. However, various synthetic chelating agents such as EDTA [13], ATA [14], EDPPA [15], DTPA [16], DMPS [17], DMSA [18], DPA [19], HEDTA [16] and Tiron [20,21] etc. have been tried to attenuate beryllium toxicity achieving limited success.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of beryllium induced alterations in hepatorenal biochemistry and ultramorphology by co-administration of tiferron and adjuvants

et al. 2007

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Influence of adjuvants i.e., alpha-tocopherol (25 mg/kg, p.o.) and piperine (10 mg/kg, p.o.) on therapeutic potential of chelator tiferron (300 mg/kg, i.p.) was evaluated to encounter toxicogenic events of beryllium exposure. Albino rats were exposed to beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by treatment of aforesaid therapeutic agents for 5 consecutive days. Results were considered to be significant at p < or =0.01 and p < or =0.05. Exposure to beryllium increased its concentration in liver, kidney and serum causing significant alterations in the activity of CYP-450 2E1 system, microsomal lipid peroxidation and protein; alkaline phosphtase, lactate dehydrogenase, gamma-glutamyl transpeptidase, bilirubin, creatinine and urea in serum; activity of acid phosphatase, alkaline phosphatase, adenosine triphosphatase, glucose-6-phosphatase and succinic dehydrogenase in liver and kidney. Beryllium exposure also induced severe alterations in histopathology and ultramorphology of liver and kidney proving its toxic consequences at cellular level. Tiferron along with adjuvants dramatically reversed alterations of all variables more towards control rather than individual treatment. Study concluded that tiferron in combination with alpha-tocopherol and piperine respectively was beneficial in diluting beryllium induced systemic toxicity; however, combination of tiferron and piperine presented more pronounced therapeutic potential.

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Section: Introductionmentioning

confidence: 99%

Amelioration of beryllium induced alterations in hepatorenal biochemistry and ultramorphology by co-administration of tiferron and adjuvants

et al. 2007

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Influence of α‐tocopherol, propolis and piperine on therapeutic potential of tiferron against beryllium induced toxic manifestations

Nirala

Bhadauria

Mathur

et al. 2007

J of Applied Toxicology

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The therapeutic potential of the chelator tiferron (sodium-4,5-dihydroxy-1,3-benzene disulphonate; 300 mg kg(-1), i.p.) and adjuvants, i.e. alpha-tocopherol (25 mg kg(-1), p.o.), propolis (a honey-bee hive product; 200 mg kg(-1), p.o.) and piperine (10 mg kg(-1), p.o.) were evaluated individually and in combination against beryllium induced biochemical alterations and oxidative stress consequences. Female albino rats were exposed to beryllium nitrate (1 mg kg(-1), i.p.) daily for 28 days followed by treatment with the above mentioned therapeutic agents for 5 consecutive days. Administration of beryllium altered blood biochemical variables with significant depletion in hemoglobin, blood sugar, total serum protein, albumin and significant enhancement in the release of serum transaminases. A significantly increased lipid peroxidation and a decreased level of glutathione after beryllium exposure indicated oxidative stress in the liver and kidney. Beryllium exposure decreased total protein and glycogen contents, whereas triglycerides and cholesterol increased significantly in liver and kidney. Individual administration of all the four compounds showed significant therapeutic potential in reverse of some of the biochemical parameters mentioned above. Furthermore, the combination of tiferron with alpha-tocopherol, propolis or piperine, respectively, could reverse all the variables significantly more towards the control. None of the test compounds showed any significant change in choleretic activity (bile flow and bile solids), indicating that these compounds had no adverse effects at these dose levels. It was concluded that all the combinations of tiferron and adjuvants played a beneficial role in reducing beryllium induced systemic toxicity at relatively lower doses and the combination of tiferron and propolis showed a more pronounced therapeutic potential.

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Pharmacology and therapeutic applications of agents used in heavy metal poisoning

Catsch

Harmuth-Hoene

1976

Pharmacology & Therapeutics. Part A: Chemotherapy, Toxicolo

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Chelating Agents in the Therapy of Beryllium Poisoning

Cited by 8 publications

References 6 publications

Amelioration of beryllium induced alterations in hepatorenal biochemistry and ultramorphology by co-administration of tiferron and adjuvants

Amelioration of beryllium induced alterations in hepatorenal biochemistry and ultramorphology by co-administration of tiferron and adjuvants

Influence of α‐tocopherol, propolis and piperine on therapeutic potential of tiferron against beryllium induced toxic manifestations

Pharmacology and therapeutic applications of agents used in heavy metal poisoning

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