Chelating polymeric beads as potential therapeutics for Wilson’s disease

Mattová, Jana; Poučková, P; Kučka, Jan; Škodová, Michaela; Vetrík, Miroslav; Štěpánek, Petr; Urbánek, Petr; Petřík, Miloš; Nový, Zbyněk; Hrubý, Martin

doi:10.1016/j.ejps.2014.05.002

Cited by 9 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cachaça is distilled in copper stills and copper contamination can take place. High accumulation of copper in the organism could cause Wilson's disease [44] and consequently toxic effects, because copper, is not excreted by the liver. This disease, if untreated, can lead to brain and liver damage.…”

Section: Discussionmentioning

confidence: 99%

Chemical Analysis of Suspected Unrecorded Alcoholic Beverages from the States of São Paulo and Minas Gerais, Brazil

Negri

Neto

Carlini

2015

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

Our study analyzed 152 samples of alcoholic beverages collected from the states of São Paulo and Minas Gerais, Brazil, using gas chromatography with flame ionization detection (GC-FID) and mass spectrometry (GC-MS), Fourier transform infrared spectroscopy (FT-IR), and inductively coupled plasma atomic emission spectrometry (ICP-AES). The methanol content varied from 20 to 180 ppm in 28 samples, and the limit of the accepted level of 200 ppm was exceeded in only one sample. High content of cyanide derivatives and ethyl carbamate, above the accepted level of 150 ppb, was observed in 109 samples. Carbonyl compounds were also observed in 111 samples, showing hydroxy 2-propanone, 4-methyl-4-hepten-3-one, furfural, and 2-hydroxyethylcarbamate as main constituents. Copper was found at concentrations above 5 ppm in 26 samples; the maximum value observed was 28 ppm. This work evaluated the human health risk associated with the poor quality of suspected unrecorded alcohols beverages.

show abstract

Section: Discussionmentioning

confidence: 99%

Chemical Analysis of Suspected Unrecorded Alcoholic Beverages from the States of São Paulo and Minas Gerais, Brazil

Negri

Neto

Carlini

2015

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

show abstract

“…However, the introduction of hydrophobic ligands may together with this additional crosslinking lead to limitation in metal binding capacity [137]. Macroreticular resin microparticles [134,140,141] with double molecular porosity (gaining access to the chelated metal to the moieties) and meso/macropores (accelerating strongly metal chelation kinetics) have the main advantage of fast metal uptake kinetics, usually within a few minutes; metal is completely complexed from solution (see Figure 6, for example), even for larger particles, where diffusion would otherwise slow down the uptake.…”

Section: Polymers With Bound Chelators To Be Applied Orallymentioning

confidence: 99%

Chelators for Treatment of Iron and Copper Overload: Shift from Low-Molecular-Weight Compounds to Polymers

et al. 2021

View full text Add to dashboard Cite

Iron and copper are essential micronutrients needed for the proper function of every cell. However, in excessive amounts, these elements are toxic, as they may cause oxidative stress, resulting in damage to the liver and other organs. This may happen due to poisoning, as a side effect of thalassemia infusion therapy or due to hereditary diseases hemochromatosis or Wilson’s disease. The current golden standard of therapy of iron and copper overload is the use of low-molecular-weight chelators of these elements. However, these agents suffer from severe side effects, are often expensive and possess unfavorable pharmacokinetics, thus limiting the usability of such therapy. The emerging concepts are polymer-supported iron- and copper-chelating therapeutics, either for parenteral or oral use, which shows vivid potential to keep the therapeutic efficacy of low-molecular-weight agents, while avoiding their drawbacks, especially their side effects. Critical evaluation of this new perspective polymer approach is the purpose of this review article.

show abstract

“…Polymeric chelators have tremendous potential in this application . Characteristics of an ideal polymer chelator include high water solubility, the ability to form non‐toxic complexes and rapid elimination of metal from the body . Polymers are non‐invasive when orally ingested and can enable the successful removal of excess heavy metal ions from the bowels …”

Section: Polymer Chelation Therapymentioning

confidence: 99%

Polymer sequestrants for biological and environmental applications

Archer

Hall

Thompson

et al. 2019

Polymer International

View full text Add to dashboard Cite

Toxic contaminates have profound consequences on both health and the environment. Consequently, effective approaches for addressing the effects of these toxicants are paramount. Here, we review recent progress in developing polymeric sequestrants for biological toxins, heavy metals and organic micropollutants. Polymers have several advantages as sequestration materials, including relatively low cost and high affinity for target compounds. As a result a number of polymer-based toxin-mitigation applications have been investigated. Naturally occurring toxins may be neutralized with polymers capable of binding and eliminating them from the body. Heavy metal contamination from mining operations, energy and industrial sources may also be mitigated with appropriate chelating polymers, both for environmental remediation and in chelation therapy for metal poisoning. Micropollutants such as pesticides from agriculture and polycyclic aromatic hydrocarbons from combustion processes may also be isolated using polymeric materials. Each of these applications illustrates the capabilities of polymers for eliminating toxic contaminants, thereby facilitating greater health and sustainability.

show abstract

Chelating polymeric beads as potential therapeutics for Wilson’s disease

Cited by 9 publications

References 18 publications

Chemical Analysis of Suspected Unrecorded Alcoholic Beverages from the States of São Paulo and Minas Gerais, Brazil

Chemical Analysis of Suspected Unrecorded Alcoholic Beverages from the States of São Paulo and Minas Gerais, Brazil

Chelators for Treatment of Iron and Copper Overload: Shift from Low-Molecular-Weight Compounds to Polymers

Polymer sequestrants for biological and environmental applications

Contact Info

Product

Resources

About