Chelidonium majus L. alkaloid extract enhances TRAIL-induced apoptosis in HeLa cell line through death receptors 4 and 5 upregulation

Parsania, Ali; Pouriayevali, Mohammad Hassan; Parsania, Masoud; Ghorbani, Mahdi

doi:10.1016/j.genrep.2021.101311

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Numerous research studies have been conducted on the chemical composition and pharmacological activity of Chelidonium majus . Most of these studies have focused on specific phytoconstituent categories found in certain parts of the plant [ 3 , 4 , 5 , 6 , 7 , 8 , 10 , 30 , 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…Currently, greater celandine is appreciated in traditional European medicine, especially in the central and eastern regions, being recognized for its exceptional therapeutic properties, especially in dermatological conditions (e.g., eczema, verrucae, circumscribed cutaneous carcinomas), hepato-biliary (anti-jaundice) conditions, chole cytopathies, biliary lithiasis, gastrointestinal spasms, eye infections, and inflammation [ 3 , 4 , 5 , 6 ]. Modern research has reported the presence of a large variety of biomolecules (alkaloids, flavonoids, carotenoids, lectins, phenolic acids, volatile oils, and others) and, thus, remarkable biological activity (antibacterial, antimicrobial, antifungal, antiviral, anti-inflammatory, antitumoral, anti-spasmodic, hepato-protective, analgesic, and immunomodulatory) [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation

Segneanu,

Vlase,

Vlase

et al. 2024

Plants

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Novel nanotechnology based on herbal products aspires to be a high-performing therapeutic platform. This study reports the development of an original engineering carrier system that jointly combines the pharmacological action of Chelidonium majus and AuNPs, with unique properties that ensure that the limitations imposed by low stability, toxicity, absorption, and targeted and prolonged release can be overcome. The metabolite profile of Romanian wild-grown Chelidonium majus contains a total of seventy-four phytochemicals belonging to eight secondary metabolite categories, including alkaloids, amino acids, phenolic acids, flavonoids, carotenoids, fatty acids, sterols, and miscellaneous others. In this study, various techniques (XRD, FTIR, SEM, DLS, and TG/DTG) were employed to investigate his new carrier system’s morpho-structural and thermal properties. In vitro assays were conducted to evaluate the antioxidant potential and release profile. The results indicate 99.9% and 94.4% dissolution at different pH values for the CG-AuNPs carrier system and 93.5% and 85.26% for greater celandine at pH 4 and pH 7, respectively. Additionally, three in vitro antioxidant assays indicated an increase in antioxidant potential (flavonoid content 3.8%; FRAP assay 24.6%; and DPPH 24.4%) of the CG-AuNPs carrier system compared to the herb sample. The collective results reflect the system’s promising perspective as a new efficient antimicrobial and anti-inflammatory candidate with versatile applications, ranging from target delivery systems, oral inflammation (periodontitis), and anti-age cosmetics to extending the shelf lives of products in the food industry.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation

Segneanu,

Vlase,

Vlase

et al. 2024

Plants

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VDR gene polymorphisms are associated with the increased susceptibility to COVID‐19 among iranian population: A case‐control study

Jafarpoor

Jazayeri

Bokharaei‐Salim

et al. 2022

Int J Immunogenetics

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Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the pathogenesis is unclear. Host genetic background is one of the main factors influencing the patients' susceptibility to several viral infectious diseases. This study aimed to investigate the association between host genetic polymorphisms of two genes, including vitamin D receptor (VDR) and vitamin D binding protein (DBP), and susceptibility to COVID-19 in a sample of the Iranian population. This case-control study enrolled 188 hospitalized COVID-19 patients as the case group and 218 suspected COVID-19 patients with mild signs as the control group. The VDR (rs7975232, rs731236 and rs2228570) and DBP (rs7041) gene single nucleotide polymorphisms (SNPs) were genotyped by Polymerase Chain Reaction Restriction -Fragment Length Polymorphism (PCR-RFLP) method. A significant association between rs2228570 SNP in the VDR gene and the susceptibility

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Chelidonium majus L. alkaloid extract enhances TRAIL-induced apoptosis in HeLa cell line through death receptors 4 and 5 upregulation

Cited by 2 publications

References 34 publications

Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation

Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation

VDR gene polymorphisms are associated with the increased susceptibility to COVID‐19 among iranian population: A case‐control study

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