Chemerin and Dermcidin in Human Milk and Their Alteration in Gestational Diabetes

Üstebay, Sefer; Baykuş, Yakup; Deniz, Rulin; Uğur, Kader; Yavuzkır, Şeyda; Yardım, Meltem; Kalaycı, Mehmet; Çağlar, Mete; Aydın, Süleyman

doi:10.1177/0890334419837523

Cited by 16 publications

(37 citation statements)

References 30 publications

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“…Furthermore, chemerin concentrations in maternal milk were increased compared with values determined in peripheral blood. Mothers with GDM had significantly higher levels in their milk compared with controls [196].…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 87%

The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

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Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans.

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Section: Gestational Diabetes Mellitusmentioning

confidence: 87%

The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

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“…Thereafter, a hydrophobic messenger peptide, consisting of 20 amino acids, is detached, while the produced proprotein is released from the cell. Proteases are responsible for the activation and formation of the final form of chemerin [ 54 ]…”

Section: Biomoleculesmentioning

confidence: 99%

“…Chemerin mRNA has been detected in many animal species, including humans, rodents, bovine, and poultry [ 55 ]. In humans, it is produced mainly by white adipose tissue (visceral and subcutaneous), liver, and placenta and to a lesser extent by brown adipose tissue, lungs, skeletal muscles, kidneys, ovaries, heart, and adrenal glands [ 54 , 55 , 56 , 57 ]. Its physiological functions involve regulation of blood pressure, immune functions, angiogenesis, and inflammation [ 58 ].…”

Section: Biomoleculesmentioning

confidence: 99%

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Ruszała

Niebrzydowska

Pilszyk

et al. 2021

IJMS

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Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. It may also affect the later stages of child development and subsequent complications in the mother. Therefore, the crux of the matter is to find a biopredictor capable of singling out women at risk of developing GDM as early as the very start of pregnancy. Apart from the well-known molecules with a proven and clear-cut role in the pathogenesis of GDM, e.g., adiponectin and leptin, a potential role of newer biomolecules is also emphasized. Less popular and less known factors with different mechanisms of action include: galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, fatty acid-binding protein 4 (FABP4), fibroblast growth factor 21, and lipocalin-2. The aim of this review is to present the potential and significance of these 13 less known biomolecules in the pathogenesis of GDM. It seems that high levels of FABP4, low levels of irisin, and high levels of under-carboxylated osteocalcin in the serum of pregnant women can be used as predictive markers in the diagnosis of GDM. Hopefully, future clinical trials will be able to determine which biomolecules have the most potential to predict GDM.

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“…Ustebay et al analyzed Chemerin and Dermicin in all phases of lactation and found that these are significantly increased by GDM; moreover, the highest amount was found in the colostrum and the lowest in mature milk [25].…”

Section: Anti-infective Proteinsmentioning

confidence: 99%

Influence of Diabetes during Pregnancy on Human Milk Composition

Peila

Gazzolo²,

Bertino

et al. 2020

Nutrients

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Human milk (HM) is a unique nourishment believed to contain biological factors contributing to both short and long-term benefits. Considering that a mother’s own milk is often considered the first choice for nutrition of neonates, an aspect of increased interest is the possible effect of diabetes on the mammary gland and therefore on breast milk composition. This article aims to review the published literature on this topic, and to offer additional insights on the role of this disease on the composition of HM. This review was performed by searching the MEDLINE, EMBASE, CINHAL and Cochrane Library databases. A total of 50 articles were selected, focused specifically on one of the two types of diabetes: gestational diabetes mellitus (21 studies) and insulin-dependent diabetes mellitus (8 studies). Overall, the findings from the literature suggest that diabetes can alter the composition of HM. Nevertheless, the studies in this field are scarce, and the related protocols present some limitations, e.g., evaluating the variability of just a few specific milk biochemical markers in association with this syndrome.

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Chemerin and Dermcidin in Human Milk and Their Alteration in Gestational Diabetes

Cited by 16 publications

References 30 publications

The Role of the Adipokines in the Most Common Gestational Complications

The Role of the Adipokines in the Most Common Gestational Complications

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Influence of Diabetes during Pregnancy on Human Milk Composition

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