Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver

Chemerin, a novel player in inflammatory bowel disease

“…3 Chemerin, which is mainly expressed in adipocytes and hepatocytes, is also present at higher concentrations in serum from IBD patients. [4][5][6] Chemerin is an attractant for immune cells and may play a role in the recruitment of tissue macrophages. 4 Chemerin produced by human fetal intestinal epithelial cells constitutes most of the chemotactic macrophage activity observed in cultured fetal intestinal epithelial cells.…”

“…6,9 Higher circulating chemerin levels in IBD may result from increased intestinal or colonic secretion. Furthermore, pro-inflammatory cytokines induce adipocytes to express chemerin but have no effect on hepatocytes 4,5 (Figure 1). Overall, the study by Lin and colleagues demonstrates a role for chemerin in IBD pathophysiology in a commonly used rodent model.…”

Chemerin in Non-Alcoholic Fatty Liver Disease ? Up or Down?

“…It is well known that chemerin is expressed in the liver and hepatocytes produce plenty of chemerin which is also secreted by these cells [2,9,10]. Hepatic stellate cells release low levels of this protein while chemerin mRNA is not detected in Kupffer cells [10].…”

“…Hepatic stellate cells release low levels of this protein while chemerin mRNA is not detected in Kupffer cells [10]. Chemerin is a ligand of the chemokine-like receptor 1 (CMKLR1) which is expressed by hepatocytes, hepatic stellate cells and Kupffer cells suggesting that chemerin affects liver cell function [11].…”

“…Three studies recently published investigated whether these metabolites also regulate hepatocyte chemerin synthesis [9,10,21]. IL-6 has, however, no effect on chemerin mRNA, cellular and soluble protein, and LPS does not increase chemerin protein in Primary Human Hepatocytes (PHH) [9,10].…”