Chemical characterization and biological activity of an endemic Amaryllidaceae species: Galanthus cilicicus

Kaya, Gulen Irem; Uzun, Kübra; Bozkurt, Buket; Önür, Mustafa; Somer, Nehir Unver; Glatzel, Daniel; Fürst, Robert

doi:10.1016/j.sajb.2016.11.008

Cited by 11 publications

(5 citation statements)

References 24 publications

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“…Moreover, the highest BuChE inhibitory activity was detected in the bulbs of the same period, which have the highest number of lycorine type alkaloids. Compared to the other Galanthus species 31,32 in which both activities were examined, the aerial parts of the fruiting period stand out with their high AChE inhibitor activity, while BuChE inhibitor activity has similar values. In conclusion, the present study clearly suggests that GC/MS is an appropriate method for the rapid analysis of the qualitative and relative amounts of alkaloid composition in G. fosteri specimens, which have diverse alkaloid structures and anticholinesterase activity.…”

Section: Discussionmentioning

confidence: 78%

GC/MS Analysis of Alkaloids in <i>Galanthus fosteri</i> Baker and Determination of Its Anticholinesterase Activity

Emir¹,

Emir²,

Bozkurt³

et al. 2020

tjps

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Amaryllidaceae alkaloitleri geniş yelpazedeki farmakolojik aktiviteleriyle iyi bilinmektedir. Bir Amaryllidaceae alkaloidi olan Galantamin, Alzheimer hastalığının tedavisi için çeşitli ülkelerde farklı ticari isimler altında pazarlanan etkili, seçici, geri dönüşümlü ve kompetitif kolinesteraz inhibitörüdür. Bu çalışma, ilk kez Galanthus fosteri Baker'in (Amaryllidaceae), hem çiçekli hem de meyveli dönemlerinin toprak üstü ve soğanlarının alkaloit profilini incelemenin yanı sıra hem asetilkolinesteraz (AChE) hem de butirilkolinesteraz (BuChE) üzerindeki inhibitör aktivitelerini analiz etmeyi amaçlamıştır. Gereç ve Yöntemler: Dört örneğin alkaloit profilleri gaz kromatografisi-kütle spektrometrisi ile belirlendi ve AChE ve BuChE inhibisyon analizleri modifiye Ellman yöntemi ile yapılmıştır. Bulgular: Ekstrelerde Amaryllidaceae alkaloitlerinin kütle spektral özellikleri olan toplam yirmi iki bileşik tespit edilmiştir. Test edilen örneklerde belirgin şekilde AChE ve BuChE inhibitör aktiviteler gözlenmiştir (IC50 0,189 ile 91,23 µg/mL arasında). Sonuç: Bu çalışma, Amasya Akdağ'dan (Türkiye) toplanan G. fosteri'nin kolinesteraz inhibitör özelliğine sahip çeşitli kimyasal yapıdaki Amaryllidaceae alkaloitlerinin kaynağı olma potansiyeline sahip olduğunu göstermiştir.

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Section: Discussionmentioning

confidence: 78%

GC/MS Analysis of Alkaloids in <i>Galanthus fosteri</i> Baker and Determination of Its Anticholinesterase Activity

Emir¹,

Emir²,

Bozkurt³

et al. 2020

tjps

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“…Similarly, methanol extracts of the bulb and aerial part of G. elwesii were selectively inhibited AChE (Bozkurt et al, 2013a;Kaya et al, 2017). Subsequent GCMS analysis revealed the present of alkaloids in the G. elwesii extract including Galanthamine, O-methylleucotamine, hordenine and sanguinine (Bozkurt et al, 2017).…”

Section: Anticholinesterase Activitymentioning

confidence: 98%

Biological Activities of Snowdrop (Galanthus spp., Family Amaryllidaceae)

et al. 2021

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Snowdrop is an iconic early spring flowering plant of the genus Galanthus (Amaryllidaceae). Galanthus species (Galanthus spp.) are economically important plants as ornaments. Galanthus spp has gained significance scientific and commercial interest due to the discovery of Galanthamine as symptomatic treatment drug for Alzhiermer disease. This review aims to discuss the bioactivities of Galanthus spp including anticholinesterase, antimicrobial, antioxidant and anticancer potential of the extracts and chemical constituents of Galanthus spp. This review highlights that Galanthus spp. as the exciting sources for drug discovery and nutraceutical development.

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“…The spectra of chromatographic peaks were investigated using Xcalibur (version 2.07, Thermo Fisher Scientific, San Jose, CA, USA). Compounds were defined by comparing the mass spectral fragmentation with the standard reference spectra of the Wiley 7N library database (Kaya et al, 2017).…”

Section: Gas Chromatograph-mass Spectrometer (Gc-ms) Analysismentioning

confidence: 99%

Comparison of three different protocols of alkaloid extraction from Glaucium corniculatum plant

Koçanci¹,

NİĞDELİOĞLU²,

Aslım³

2022

International Journal of Secondary Metabolite

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Alkaloids, plant secondary metabolites, have a wide variety of biological effects. For this reason, the extraction of alkaloids from plants is of strategic importance. Different extraction protocols for the extraction of alkaloids from plants have been described by many authors. The objective of this study was to compare the efficacy of three different protocols for the extraction of alkaloids from Glaucium corniculatum. This article compares the Soxhlet and ultrasonication protocol, used in previous studies, to a modified Soxhlet protocol. While the alkaloid amount in the extract was determined by the spectrophotometric method, the qualitative estimation of the compounds in the extract was determined by Gas chromatograph-Mass spectrometer (GC-MS). The alkaloid amount and diversity in the extract, obtained through the recommended modified Soxhlet protocol, were higher than that of any extract obtained through other protocols. Thus, a new modified alkaloid extraction protocol was established, which is better than the other protocol.

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Chemical characterization and biological activity of an endemic Amaryllidaceae species: Galanthus cilicicus

Cited by 11 publications

References 24 publications

GC/MS Analysis of Alkaloids in <i>Galanthus fosteri</i> Baker and Determination of Its Anticholinesterase Activity

GC/MS Analysis of Alkaloids in <i>Galanthus fosteri</i> Baker and Determination of Its Anticholinesterase Activity

Biological Activities of Snowdrop (Galanthus spp., Family Amaryllidaceae)

Comparison of three different protocols of alkaloid extraction from Glaucium corniculatum plant

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