Chemical colitis due to endoscope cleaning solutions: A mimic of pseudomembranous colitis

Jonas, Gavin M.; Mahoney, Antoinette; Murray, Johnson; Gertler, Stanford L.

doi:10.1016/0016-5085(88)90380-0

Cited by 103 publications

(41 citation statements)

References 6 publications

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“…Improper rinsing of GA after disinfection can be harmful to the next patient, incurring abdominal pain and other symptoms of gastroenteritis 15-17. In terms of the limit in the number of use, dilution of the GA solution (under 2%) for repeated use may lead to decreased effectiveness.…”

Section: Chemicals and Disinfectants In Usementioning

confidence: 99%

A Review of Current Disinfectants for Gastrointestinal Endoscopic Reprocessing

et al. 2013

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Gastrointestinal endoscopy is gaining popularity for diagnostic and therapeutic purposes. However, concerns over endoscope-related nosocomial infections are increasing, together with interest by the general public in safe and efficient endoscopy. For this reason, reprocessing the gastrointestinal endoscope is an important step for effective performance of endoscopy. Disinfectants are essential to the endoscope reprocessing procedure. Before selecting an appropriate disinfectant, their characteristics, limitations and means of use must be fully understood. Herein, we review the characteristics of several currently available disinfectants, including their uses, potency, advantages, and disadvantages. Most disinfectants can be used to reprocess gastrointestinal endoscopes if the manufacturer's guidelines are followed. The selection and use of a suitable disinfectant depends on the individual circumstances of each endoscopy suite.

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Section: Chemicals and Disinfectants In Usementioning

confidence: 99%

A Review of Current Disinfectants for Gastrointestinal Endoscopic Reprocessing

et al. 2013

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“…In the past it was used for therapeutic enemas to relieve meconium ileus in infants and fecal impaction in adults for nearly 100 years [1], but this practice has largely been abandoned after it was proven that it can cause colonic damage similar to that of ulcerative colitis or pseudomembranous colitis [1,2]. There are some case reports of chemical colitis resulting from self-administered hydrogen peroxide enema in naturopathic therapy in adults [2,3], but no case has been reported of caustic injury after ingesting hydrogen peroxide in children. We report a rare case of severe, acute colitis after administration of a hydrogen peroxide enema in a child.…”

Section: Introductionmentioning

confidence: 99%

Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review

Lee

Yoo

2016

Environ Health Toxicol

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A 2-year-old girl, previously healthy, was brought to the emergency department because of significant cramping abdominal pain with recurrent hematochezia after an accidental hydrogen peroxide enema (35%, 5 mL) by her caregiver. She was hospitalized to the pediatric department and treated with nothing per mouth, intravenous fluid and parenteral antibiotic therapy. Laboratory, radiologic and endoscopic evaluation was performed during the admission period. She was discharged in a fully recovered state on the tenth hospital day, and this is the first case report of acute chemical colitis by accidental hydrogen peroxide enema in children.

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“…There are also some cases that presented 5-12 h after the colonoscopy [1,7]. Endoscopic findings include nonspecific exudative fibrinohemorrhagic and purulent membranes consistent with erosion or ulceration of the mucosa, which mimics ischemic colitis, inflammatory bowel disease and pseudomembranous enterocolitis [1,7,8]. Histopathologically, there is a marked congestion and extravasation of red blood cells in the superficial lamina propria, mucin depletion, attenuation or loss of the epithelium lining, the surface and the upper portion of the glands, a surface erosion with a fibrinohemorrhagic, purulent exudate, preservation of the regenerative base of the crypts, and a scant inflammatory cellular infiltrate.…”

Section: Discussionmentioning

confidence: 99%

Chemical Colitis Due to Glutaraldehyde: Case Series and Review of the Literature

et al. 2008

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Chemical colitis can occur as a result of accidental contamination of endoscopes or by intentional/accidental administration of enemas containing various chemicals.We present three cases of glutaraldehyde induced colitis and review the cases in the literature. Glutaraldehyde induced colitis presents clinically with severe abdominal pain, bloody and mucoid diarrhea, rectal bleeding, and tenesmus 48-72 h after colonoscopy. Endoscopic findings are nonspecific and mimic ischemic colitis, inflammatory bowel disease, and infectious colitis. The timing of symptoms and the knowledge that glutaraldehyde is a chemical irritant to colonic mucosa is important for the diagnosis. The treatment is mainly supportive but sometimes necessitates mesalamine, prednisolone, or metronidazole and the resolution is rapid. In endoscopy units, strict adherence to published disinfection protocols is very important and the cleaning, rinsing and drying protocols also deserve the same attention.

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Chemical colitis due to endoscope cleaning solutions: A mimic of pseudomembranous colitis

Cited by 103 publications

References 6 publications

A Review of Current Disinfectants for Gastrointestinal Endoscopic Reprocessing

A Review of Current Disinfectants for Gastrointestinal Endoscopic Reprocessing

Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review

Chemical Colitis Due to Glutaraldehyde: Case Series and Review of the Literature

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