Chemical composition and antibacterial activity of essential oil from leaves of Croton heliotropiifolius in different seasons of the year

Filho, José M.T. de Alencar; Araújo, Luciana da C.; Oliveira, Ana Paula de; Guimarães, Amanda Leite; Pacheco, Alessandra Gomes Marques; Silva, Fabrício Souza; Cavalcanti, L. S.; Lucchese, Angélica Maria; Almeida, Jackson Roberto Guedes da Silva; Araújo, Edigênia Cavalcante da Cruz

doi:10.1016/j.bjp.2017.02.004

Cited by 43 publications

(42 citation statements)

References 24 publications

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“…The effect of season has been investigated by numerous authors, as each plant reacts differently to seasonal changes and different metabolic pathways are responsible for production of the various secondary metabolites in both colder and warmer months (Prinsloo and Nogemane, 2018). Plants such as Rosmarinus officinalis, Salvia fruticose, and Croton heliotropiifolius contain higher concentrations of active compounds in summer and spring months (Lemos et al, 2015;Sarrou et al, 2016;de Alencar Filho et al, 2017). On the contrary many reports described increased activity and active compound levels in the colder months for example Calamintha nepeta, Phillyrea angustifolia, and Thymus longicaulis (Scognamiglio et al, 2014;Pacifico et al, 2015), whereas in some plants seasonal variation does not affect the chemical composition such as in Vaccinium myrtillus (Bujor et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

1H-NMR Metabolomics and LC-MS Analysis to Determine Seasonal Variation in a Cosmeceutical Plant Leucosidea sericea

2020

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Leucosidea sericea is an evergreen shrub belonging to the Rosaceae family with previous studies that indicated that L. sericea extracts exhibited strong anti-bacterial properties against Propionibacterium acnes, showing potential as a cosmeceutical. The plant is traditionally used as a vermifuge, as an astringent and to treat conjunctivitis. Commercial production is, however, not possible as no information is available on cultivation and the effect of external environmental factors such as seasonal variation on the medicinal properties of the plant. Seasonal variation was investigated and it was found that significant differences were observed between the anti-acne (P. acnes) activity of plant material collected in different seasons. The best activity was found in winter with a mean minimum inhibitory concentration (MIC) of 5.20 µg mL −1 compared to spring at 26.04 µg mL −1. A 1 H NMR-based untargeted metabolomic analysis was used to determine the differences in the chemical profiles of plant samples collected in different seasons. Principal component analysis (PCA) showed clear separation of the seasons and a supervised orthogonal partial least square discriminant analysis (OPLS-DA) was used to determine the compounds that differentiated the spring from the winter samples. The contribution plot indicated a strong positive association with the NMR regions from δ 1.2-1.6, 3.3-4.1, and 6.8-8.0 ppm indicative of a compound with an aromatic ring. Different LC-MS analyses were used in conjunction with a compound database, MAGMa and CSIFingerID, which led to the identification of the compound 2-(4-ethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one and also confirmed the presence of tangeritin, rutin, quercetin glucoside, and kaempferol glucosides as well as several other compounds previously identified from the plant. This compound similar in structure to the anti-microbial flavonoid tangeritin, was only present in the winter samples. It is therefore recommended that seasonal variation be closely monitored during cultivation and commercial harvesting, and that winter is the preferred harvesting season to obtain the best anti-acne activity.

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Section: Discussionmentioning

confidence: 99%

1H-NMR Metabolomics and LC-MS Analysis to Determine Seasonal Variation in a Cosmeceutical Plant Leucosidea sericea

2020

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“…Natural ingredients in many plants can kill or inhibit the growth of harmful microorganisms in food. There is an increased interest focusing on essential oils as alternative agents for the control of food corruption and harmful microbial reproduction [ 8 , 9 , 10 ]. A number of reports have demonstrated the antibacterial properties of the SAEO [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Selective Encapsulation of Hydroxypropyl-β-cyclodextrin on Components and Antibacterial Properties of Star Anise Essential Oil

2018

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Star anise essential oil (SAEO) is a plant essential oil with good antibacterial activity, but its applications are limited due to its high volatility, strong smell, and unstable physical and chemical properties. The effect of selective encapsulation of SAEO by hydroxypropyl-β-cyclodextrin (HPCD) on its compositions, volatility stability and antibacterial activity was investigated. The GC-MS results indicated that the compositions reduced and content of the compositions of SAEO changed after encapsulation. Most of the components in SAEO were successfully encapsulated by HPCD, which can be supported by data from FTIR and 1H NMR. According to the molecular modeling results, the three guest molecules (trans-anethole, estragole and trans-foeniculin) were all docked in the cavity of HPCD on the isoallyl (or allyl) side. The volatile stability of SAEO before and after encapsulation was evaluated by electronic nose, and the results confirmed that encapsulation significantly reduced the irritating smell of SAEO and makes the clathrate have a sustained release effect. Furthermore, in the antibacterial test, the selective encapsulation of HPCD improved the inhibition effect of SAEO on Rhizopus stolonoifer, Saccharomyces cerevisiae, and E. coli and its antibacterial stability in 24 h.

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“…Minyak atsiri memiliki aktivitas farmakologi antara lain antiseptik, bakterisida, virusida, fungisida, dan sifatsifat farmakologi yang lain. 2 Minyak atsiri umumnya dijumpai pada jenis tanaman yang memiliki bau atau aroma. Tembakau merupakan salah satu tanaman yang memiliki aroma yang khas.…”

Section: Pendahuluanunclassified

Aktivitas Antibakteri Minyak Atsiri Daun Tembakau terhadap Pertumbuhan Bakteri Escherichia coli dan Staphylococcus aureus

Nurnasari

Wijayanti²

2019

jki

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Tobacco plants are widely used as raw material for cigarettes, but the results of the study show that in tobacco leaves contain compounds that can be used in the pharmaceutical and health fields. Tobacco leaves contain essential oils that have a distinctive aroma. The study aims to examine the antibacterial activity of tobacco essential oil from six sources tobacco such as Temanggung, Yogyakarta, Purwodadi, Boyolali, Blitar and Probolinggo. Tobacco essential oil is obtained by the steam-water distillation method. Antibacterial activity evaluation was carried out by diffusion method and the minimum inhibitory concentration on two bacteria, Escherichia coli and Staphylococcus aureus. The yield of tobacco essential oil ranged from 0.54-3.39%. Tobacco essential oil had antibacterial activity against bacteria E. coli and S. aureus in the presence of inhibition zones in bacterial media. The biggest inhibition zone was in Yogyakarta tobacco essential oil of 26 mm for S. aureus bacteria, while for E. coli bacteria the biggest inhibition zone was Blitar tobacco essential oil which was equal to 21 mm. The inhibition zone was not much different from the inhibition zone in tetracycline antibiotic testing (positive control) which was 25 mm in S. aureus and 21.5 mm bacteria in E. coli bacteria. Tobacco essential oil from Probolinggo was able to inhibit the growth of S. aureus bacteria up to a concentration of 6.25% and E. coli bacteria to a concentration of 12.5%.

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Chemical composition and antibacterial activity of essential oil from leaves of Croton heliotropiifolius in different seasons of the year

Cited by 43 publications

References 24 publications

1H-NMR Metabolomics and LC-MS Analysis to Determine Seasonal Variation in a Cosmeceutical Plant Leucosidea sericea

1H-NMR Metabolomics and LC-MS Analysis to Determine Seasonal Variation in a Cosmeceutical Plant Leucosidea sericea

Effect of Selective Encapsulation of Hydroxypropyl-β-cyclodextrin on Components and Antibacterial Properties of Star Anise Essential Oil

Aktivitas Antibakteri Minyak Atsiri Daun Tembakau terhadap Pertumbuhan Bakteri Escherichia coli dan Staphylococcus aureus

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