Chemical composition and antifungal activity of Hedera helix leaf ethanolic extract

Abstract

The 50% ethanol extract obtained from Hedera helix leaves was investigated regarding the presence and quantity of polyphenols, sterols and in vitro antifungal activity against phytopathogenic fungi. The chemical analysis revealed the presence of rutin, quercetin and kaempferol in the non-hydrolysed sample and quercetin and kaempferol in the hydrolysed sample and stigmasterol in the ivy leaf extract (nonhydrolysed sample). The antifungal activity against phytopathogenic fungi (Aspergillus niger, Botrytis cinerea, B. tulipae, Fusarium oxysporum f. sp. tulipae, Penicillium gladioli, and Sclerotinia sclerotiorum) was assessed using an agar dilution assay. The results are expressed as the minimum inhibitory concentration (MIC = 10-14%) and were compared to a synthetic antifungal drug - fluconazole (MIC = 8-30%). This report presents the first screening of the antifungal activity of the ivy leaf extract on these plant pathogenic fungi species, aiming to use the ivy leaf extract for controlling different diseases of vegetables and ornamental plants, in addition to human disorders.

An investigation of the antileishmanial properties of semi-synthetic saponins

“…57 More recently, anti-viral 58 and anti-cancer properties 20,59 have been reported. Extracts also show potent anti-fungal properties, 60,61 but of particular interest were the reports of anti-leishmanial saponins extracted from H. helix. 36,43,50,53,62 Extracted and purified monodesmoside triterpenoid saponins (α-, βand δ-hederin) demonstrated activity against both promastigote (insect stage) and intracellular amastigote (mammalian stage) forms of both L. tropica and L. infantum.…”

Common Ivy (Hedera Helix L.) as a Novel Green Resource in an Urban Biorefinery Concept

“…Emerging fungi pose a significant risk to the global food supply; therefore, novel disease control strategies should be investigated. 100 Consequently, Rosca-Casian et al 20 researched the antifungal activity of a 50% ethanol CI leaf extract against 6 phytopathogenic fungi strains. Results were positive and comparable with fluconazole, a synthetic drug.…”

“…As it stands, these trimmings have shown to possess significant quantities of extractable pharmaceutically active compounds . Extracts of CI are commercially applied as cough syrup (e.g., Prospan) and possess antioxidant, anti-inflammatory, anticarcinogenic, and antifungal properties . A subsequent phase in the proposed biorefinery process uses the spent (extracted) CI residue stream as a feedstock for bioproduct manufacturing.…”

“…16 Extracts of CI are commercially applied as cough syrup (e.g., Prospan) and possess antioxidant, 17 antiinflammatory, 18 anticarcinogenic, 19 and antifungal properties. 20 A subsequent phase in the proposed biorefinery process uses the spent (extracted) CI residue stream as a feedstock for bioproduct manufacturing. The application potential for the fractionation of spent CI trimmings into its lignocellulosic fractions (hemicellulose, cellulose, and lignin) is discussed.…”

Bioactive phenolics fraction of Hedera helix L. (Common Ivy Leaf) standardized extract ameliorates LPS-induced acute lung injury in the mouse model through the inhibition of proinflammatory cytokines and oxidative stress

“…Ivy leaf extracts have demonstrated mucolytic, antispasmodic, bronchodilator, and antibacterial effects ( Sieben et al., 2009 ), and so are administered for productive acute cough, upper respiratory tract disorders, and chronic inflammatory bronchial conditions ( Lutsenko et al., 2010 ). These extracts are able to stimulate the gastric mucosa and, in turn, increase the secretion of bronchial mucus by parasympathicotonic reflexes due to the presence of a low amount of emetine in ivy leaves extracts ( Roşca-Casian et al., 2017 ). Hederasaponins C, E, and F may also reduce bronchial inflammation by disrupting leukotriene signaling, as bradykinin and prostaglandin responses ( Gepdiremen et al., 2005 ).…”