Chemical composition and antimicrobial activity of the essential oil of <i>Sideritis cypria</i> Post endemic in Northern Cyprus

Hanoğlu, Duygu Yiğit; Hanoğlu, Azmi; Güvenir, Meryem; Süer, Kaya; Demirci, Betül; Başer, K. Hüsnü Can; Yavuz, Dudu Özkum

doi:10.1080/10412905.2016.1251503

Cited by 10 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All these components were identified as well by previous studies of the plant during flowering phase, but with different percentages, while b-phellanderene was identified again as the major compound (17.83%) (Hanoglu et al, 2020). The same authors referenced their previous work (Hanoglu et al, 2016) mentioning that when oils from post flowering stage were analyzed, the compounds and their amounts varied, compared to those during flowering. Plants evaluated in this study were collected during flowering stage, and leaves' oil profile is similar to the report of Hanoglu et al (2020), but with differences mostly in secondary compounds, in terms of their participation in the oil profile.…”

Section: Discussionmentioning

confidence: 55%

“…The present study revealed the chemical variation of the flowers and leaves essential oils (EOs) in comparison to the wild population of S. cypria previously investigated (Hanoglu et al, 2016). The main constituents of the aerial parts of wild S. cypria EO were epi-cubebol (11.9%), trans-piperitol (8.9%), a-pinene (4.3%), and b-pinene (3.6%), while the main constituents of the flowers and leaves EOs were a-/b-pinenes in significant higher concentration, sabinene, bphellandrene (ca.…”

Section: Discussionmentioning

confidence: 81%

“…S. cypria follows the same trend, with the flower's essential oil yield to be significantly higher (0.25%) than leaves' yield, which was measured at considerably low numbers of 0.03%. Hanoglu et al (2016;2020) recorded a yield of 0.49%, when hydrodistilled S. cypria plants, during or post-flowering that were collected from mountains in north Cyprus (500-750 m altitude). This variation with the present results might be attributed that wild harvested plant tissue in mountain areas (Hanoglu et al, 2016;Hanoglu et al, 2020) can differ on the essential oil yield and aromatic profile, compared with cultivated crop in lowland.…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, the infusion of S. cypria is locally used as diaphoretic, tonic, as well as against stomach disorders, headache and common cold (Yöney et al, 2010;Karousou and Deirmentzoglou, 2011;Hanoglu et al, 2020). Hanoglu et al (2016) reported the antimicrobial efficacy of essential oils derived by S. cypria, and suggested to be used as a new medicinal resource particularly against C. albicans and Gram-positive bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…However, the secondary metabolites of the traditional infusion of this plant are still undershadowed. The literature survey revealed only two publications concerning the chemical characterization of wild harvested S. cypria of its essential oil (Hanoglu et al, 2016) and extracts (Hanoglu et al, 2020). Therefore, for the purpose of this study, we investigated and compared for the first time the chemical composition of the traditional infusions of different plant parts, leaves and flowers, of cultivated S. cypria.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Traditionally Used Sideritis cypria Post.: Phytochemistry, Nutritional Content, Bioactive Compounds of Cultivated Populations

et al. 2020

View full text Add to dashboard Cite

Sideritis species are recognized as important medicinal plants and their commercial demand is continuously on the rise both in the European and in the global market. Consequently, the cultivation of Sideritis species has been occurred to successfully meet the need for mass production of high-quality plant material. The present study was undertaken in order to investigate the chemical composition of cultivated S. cypria. Infusions of flowers and leaves were prepared separately, according to the European Medicine Agency (EMA) monograph. The infusion of the flowers revealed the presence of four flavones, isoscutellarein-7-O-[6′″-O-acetyl-b-D-allopyranosyl-(1!2)-b-Dglucopyranoside, its 4′-O-methyl-derivative, 4′-O-methyl-hypolaetin-7-O-[6′″-O-acetylb-D-allopyranosyl-(1!2)-b-D-glucopyranoside, and isoscutellarein-7-O-[6′″-O-acetyl-b-D-allopyranosyl-(1!2)]-6″-O-acetyl-b-D-glucopyranoside; four phenylethanoid glucosides, acteoside, leucosceptoside A, lamalboside, and leonoside A; one iridoid, melittoside, and one phenolic acid, chlorogenic acid, while the infusion of the leaves of the same population afforded the same first two flavones; five phenylethanoid glucosides, acteoside, leucosceptoside A, lavandulifolioside, leonoside A, and lamalboside; melittoside and chlorogenic acid. The structural elucidation of the isolated compounds was undertaken by high-field NMR spectroscopy. Moreover, the essential oils of the flowers and leaves were studied by GC-MS, separately. In addition, the mineral, bioactive compounds, protein and carbohydrate contents were evaluated for both plant materials.

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Traditionally Used Sideritis cypria Post.: Phytochemistry, Nutritional Content, Bioactive Compounds of Cultivated Populations

et al. 2020

View full text Add to dashboard Cite

show abstract

Bio‐Guided Investigation of Sideritis cypria Methanol Extract Driven by in Vitro Antioxidant and Cytotoxic Assays

Lytra

Tomou

Chrysargyris

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

Sideritis cypria Post is an endemic and endangered species of Northern Cyprus. The overall aim of the present study was to evaluate the total phenolic content, the antioxidant, the cytotoxic and the antimicrobial activity of the methanol extract obtained from the aerial parts of cultivated S. cypria. A bio‐guided approach led to the isolation of 27 chemical compounds by using various analytical techniques. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy. The crude extract exerted strong antioxidant activity (DPPH and FRAP assays) which was attributed to its high total phenolic content. Furthermore, groups rich in phenolic content showed highest antioxidant property, whereas groups with phytosterols, diterpenoids and apigenin derivatives exerted cytotoxic effects in MDA‐MB231 cancer cell line by the MTT method. Moreover, the cytotoxic activity of four isolated apigenin derivatives was evaluated in the same cancer cells. The antimicrobial activity of the extract and groups were measured, demonstrating lack of activity. To the best of our knowledge, this survey is the first report on the biological activities of the methanol extract of S. cypria.

show abstract

Sideritis L. essential oils: A systematic review

et al. 2023

View full text Add to dashboard Cite

Chemical composition and antimicrobial activity of the essential oil of Sideritis cypria Post endemic in Northern Cyprus

Cited by 10 publications

References 29 publications

Traditionally Used Sideritis cypria Post.: Phytochemistry, Nutritional Content, Bioactive Compounds of Cultivated Populations

Traditionally Used Sideritis cypria Post.: Phytochemistry, Nutritional Content, Bioactive Compounds of Cultivated Populations

Bio‐Guided Investigation of Sideritis cypria Methanol Extract Driven by in Vitro Antioxidant and Cytotoxic Assays

Sideritis L. essential oils: A systematic review

Contact Info

Product

Resources

About