Chemical Composition and Antimicrobial Activity of the Essential Oil from<i>Microlicia crenulata</i>

Pereira, Maria do Carmo; Nelson, David Lee; Stoianoff, Maria Aparecida Resende; Santos, Simone Gonçalves Dos; Nogueira, Luciano José; Coutinho, Simone Cristina; Carvalho, Maria Auxiliadora Roque de; Barbosa, Luiz Cláudio de Almeida

doi:10.1080/0972060x.2014.935055

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…Some phytochemical studies have indicated the presence of essential oils in aerial parts of Lavoisiereae species (Toudahl et al 2012; Cassiano et al 2014; Pereira et al 2015; Fernandes et al 2017), but it is uncertain whether glandular trichomes produce these oils. The chemical composition of the secretion and functions of glandular trichomes in Lavoisiereae are practically unknown and should be investigated from both ecological and chemical perspectives.…”

Section: Taxonomic Treatmentmentioning

confidence: 99%

Three New Species of the Megadiverse Genus Microlicia (Melastomataceae) with Notes on Leaf Anatomy

Romero,

Caetano,

Santos

et al. 2023

Systematic Botany

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Abstract— The new species Microlicia arenaria, M. dentisepala, and M. membranacea are described from the Diamantina Plateau, Minas Gerais state, Brazil. Microlicia arenaria is a cespitose subshrub with xylopodium, fastigiate branches, forming clumps, sessile leaves, linear lamina, and hypanthium and sepals covered with golden spherical glands. In addition, it has dimorphic and bicolored stamens with tetrasporangiate anthers. Microlicia dentisepala has a subshrub or shrub habit, is erect and much branched, and its leaves are small, varnished in appearance, with both surfaces covered with spherical glands. The sepals are triangular to narrowly lanceolate and shorter than the length of the hypanthium, with a tooth aspect. Microlicia membranacea is a subshrub with petiolate leaves, lamina of membranous consistency and suprabasal venation, with prominent secondary veins. The branch, leaf, hypanthium, and sepals are covered with glandular trichomes, and the cylindrical hypanthium is slightly contracted at the apex. Microlicia arenaria and M. dentisepala exhibit some anatomical features common to Microlicia, such as amphistomatic leaves, short-stalked glandular trichomes in depressions on the leaf surface, compact mesophyll, phenolic compounds in the subepidermal layer, idioblasts with druses in the mesophyll, and collateral vascular bundles. Microlicia membranacea stands out by its hypostomatic leaves and a thin mesophyll formed by only three to four cell layers, conditions possibly related to a shaded environment. Following the criteria of the Red List of the International Union for Conservation of Nature (IUCN), we preliminarily assess the conservation status of the species Microlicia arenaria as Endangered (EN), Microlicia dentisepala as Critically Endangered (CR), and Microlicia membranacea as Data Deficient (DD). We provide descriptions of the new species, along with field images, detailed illustrations, and comparisons with related species. Data on geographic distribution and habitat are also presented.

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Section: Taxonomic Treatmentmentioning

confidence: 99%

Three New Species of the Megadiverse Genus Microlicia (Melastomataceae) with Notes on Leaf Anatomy

Romero,

Caetano,

Santos

et al. 2023

Systematic Botany

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“…S16). It is worth noting that phenylacetaldehyde has been previously identified as a major fragrance compound present in the essential oil and honey of numerous Myrtaceae plants (39)(40)(41), which may be attributed to the activity of EgPAAS. Unlike the PsTyDC H205N mutant, EgPAAS shows no detectable ancestral AAAD activity, suggesting that in addition to the small-loop His-to-Asn substitution other adaptive mutations must have contributed to the specific PAAS activity.…”

Section: Convergent Evolution Of Two Mechanistic Classes Of Aassmentioning

confidence: 99%

Structural basis for divergent and convergent evolution of catalytic machineries in plant aromatic amino acid decarboxylase proteins

Torrens-Spence

Chiang

Smith

et al. 2018

Preprint

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AbstractRadiation of the plant pyridoxal 5’-phosphate (PLP)-dependent aromatic L-amino acid decarboxylase (AAAD) family has yielded an array of paralogous enzymes exhibiting divergent substrate preferences and catalytic mechanisms. Plant AAADs catalyze either the decarboxylation or decarboxylation-dependent oxidative deamination of aromatic L-amino acids to produce aromatic monoamines or aromatic acetaldehydes, respectively. These compounds serve as key precursors for the biosynthesis of several important classes of plant natural products, including indole alkaloids, benzylisoquinoline alkaloids, hydroxycinnamic acid amides, phenylacetaldehyde-derived floral volatiles, and tyrosol derivatives. Here, we present the crystal structures of four functionally distinct plant AAAD paralogs. Through structural and functional analyses, we identify variable structural features of the substrate-binding pocket that underlie the divergent evolution of substrate selectivity toward indole, phenyl, or hydroxyphenyl amino acids in plant AAADs. Moreover, we describe two mechanistic classes of independently arising mutations in AAAD paralogs leading to the convergent evolution of the derived aldehyde synthase activity. Applying knowledge learned from this study, we successfully engineered a shortened benzylisoquinoline alkaloid pathway to produce (S)-norcoclaurine in yeast. This work highlights the pliability of the AAAD fold that allows change of substrate selectivity and access to alternative catalytic mechanisms with only a few mutations.SignificancePlants biosynthesize their own proteinogenic aromatic L-amino acids, namely L-phenylalanine, L-tyrosine and L-tryptophan, not only for building proteins but also for the production of a plethora of aromatic-amino-acid-derived natural products. Pyridoxal 5’-phosphate (PLP)-dependent aromatic L-amino acid decarboxylase (AAAD) family enzymes play important roles in channeling various aromatic L-amino acids into diverse downstream specialized metabolic pathways. Through comparative structural analysis of four functionally divergent plant AAAD proteins together with biochemical characterization and molecular dynamics simulations, we reveal the structural and mechanistic basis for the rich divergent and convergent evolutionary development within the plant AAAD family. Knowledge learned from this study aids our ability to engineer high-value aromatic-L-amino-acid-derived natural product biosynthesis in heterologous chassis organisms.

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Volatile oils: Potential agents for the treatment of respiratory infections

Pasdaran

Sheikhi²

2016

The Microbiology of Respiratory System Infections

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Chemical Composition and Antimicrobial Activity of the Essential Oil fromMicrolicia crenulata

Cited by 6 publications

References 12 publications

Three New Species of the Megadiverse Genus Microlicia (Melastomataceae) with Notes on Leaf Anatomy

Three New Species of the Megadiverse Genus Microlicia (Melastomataceae) with Notes on Leaf Anatomy

Structural basis for divergent and convergent evolution of catalytic machineries in plant aromatic amino acid decarboxylase proteins

Volatile oils: Potential agents for the treatment of respiratory infections

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