Chemical Composition and Antimicrobial Activity of Essential Oil of <i>Heracleum rigens</i>

Jagannath, Nataraj; Ramakrishnaiah, H.; Krishna, V.; Gowda, Prameela Javarayi

doi:10.1177/1934578x1200700737

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…Another ester, n-octyl acetate, was reported as a common component in most fruit oils of Heracleum genus [12]. Bornyl acetate (51.20%) was the major compound in the essential oil of Heracleum rigens seeds [13]. The differences between our study and others could be explained by the fact that we investigated the whole aerial parts of the plant.…”

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confidence: 60%

Antibacterial Activity of the Essential Oil of Heracleum Sibiricum

Miladinović

Ilić

Mihajilov‐Krstev

et al. 2013

Natural Product Communications

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The composition and antimicrobial activity of the essential oil of Heracleum sibiricum L. (Apiaceae) was studied. The aerial part of plant was hydro-distilled and chemical composition of the essential oil was analyzed by GC and GC-MS. Forty-six compounds, corresponding to 95.12% of the total oil, were identified. Esters represented the major chemical class (69.55%) while the main constituents were octyl butanoate (36.82%), hexyl butanoate (16.08%), 1octanol (13.62%) and octyl hexanoate (8.10%). Antibacterial activity of the essential oil and reference antibiotics against nine bacterial strains was tested by the broth microdilution method. The results of the bioassays showed that essential oil had slight antimicrobial activities against all tested microorganisms (MIC and MBC values were in the range of 2431.2 to 9724.8 μg/mL). Reference antibiotics were active in concentrations between 0.5 and 16.0 μg/mL. The results confirm that Gram-positive bacteria were more susceptible to the essential oil of H. sibiricum, in comparison with Gram-negative bacteria.

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confidence: 60%

Antibacterial Activity of the Essential Oil of Heracleum Sibiricum

Miladinović

Ilić

Mihajilov‐Krstev

et al. 2013

Natural Product Communications

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“…However, there is no particular data suggesting synergism between bornyl acetate and other terpenes. Some studies have demonstrated synergism mainly produced between oxygenated terpenes (Sokovic et al 2010;Fidan et al 2019;Bassole and Juliani 2012;Novato et al 2019;Gavaric et al 2015;Jagannath et al 2012). Thus, in further studies, synergism of bornyl acetate with other terpenes should be investigated.…”

Section: Discussionmentioning

confidence: 95%

“…The described approach focused on major compounds found in CEOs since full-deck quantification of all terpenes is not feasible due to lack of reference material and detection limits. Based on the previous analysis of the chemical composition of CEOs and the knowledge of their possible antibacterial properties, eight terpenes are chosen for this study (Jagannath et al 2012). The relative amounts of the selected terpenes in the analyzed CEOs are presented in Supplementary Table 7S.…”

Section: Discussionmentioning

confidence: 99%

Absolute quantification of terpenes in conifer-derived essential oils and their antibacterial activity

Allenspach

Valder²

2020

J Anal Sci Technol

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A simple, robust, and precise method for the absolute quantification of the terpenes α-pinene, camphene, βpinene, 3-carene, limonene, bornyl acetate, β-caryophyllene, and borneol was developed using gas chromatography coupled to a flame ionization detector (GC-FID) and validated according to the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use. The GC-FID method shows high accuracy (91-105%) and low imprecision (< 7.6%) for all terpenes at quality control (QC) low, medium, and high level. The curves are linear with strong correlation (R 2 ≥ 0.999) for all terpenes. Additionally, the relative response factor (RRF) for each terpene is calculated. The method was validated in terms of specificity, linearity, accuracy, precision, LOD, LOQ, stability tests, and carry-over. The method was successfully applied to quantify the selected terpenes in conifer-derived essential oils (CEOs). The total amount of terpenes ranged from 6.3 to 11.8 mM. Additionally, the CEOs were screened in vitro for the antibacterial activity against E. coli and S. aureus using the broth microdilution method to determine the minimum inhibitory concentration (MIC). All the CEOs showed antibacterial activity in the concentration from 0.3 to 50 μg/mL (S. aureus) and 1.2 to 50 μg/mL (E. coli), respectively. CEO14 showed the most effective antibacterial activity of the entire tested CEOs (MIC values 0.3 μg/mL (S. aureus); 1.2 μg/mL (E. coli)). Our results suggest that the terpenoid profile should be considered for a comprehensive evaluation of the antibacterial activity, as none of the single compounds seems to be fully responsible for antibacterial activity.

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“…Likewise, the essential oils showed weak antibacterial property against Gram‐positive bacterial strains of S. aureus and Staphylococcus epidermis with no measurable effect on E. coli and P. aeruginosa (Torbati and others ). Jagannath and others () tested the antimicrobial effects of H. rigens against 9 pathogenic bacteria. Maximum activity was noted for Klebsiella pneumonia and B. subtilis .…”

Section: Biological Activitiesmentioning

confidence: 99%

The Genus Heracleum: A Comprehensive Review on Its Phytochemistry, Pharmacology, and Ethnobotanical Values as a Useful Herb

Bahadori

Dinparast

Zengin

2016

Comp Rev Food Sci Food Safe

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Heracleum species, also known as hogweed, are traditionally used as food additives, spices, and flavoring agents. Moreover, these plants are widely used in folklore medicine for the treatment of many disorders such as inflammation, flatulence, stomachache, epilepsy, psoriasis, and as carminative, wound healing, antiseptic, antidiarrheal, tonic, digestive, pain killer, analgesic, and anticonvulsant agents. The genus Heracleum has broad pharmacological activities: anti-inflammatory, antimicrobial, anticholinesterase, anti-oxidant, antiviral, cytotoxic, and anticarcinogenic. A total of 94 compounds have been isolated from plants of the Heracleum genus, all indicating vital biological activities. Also, about 50 compounds have been identified as major components in their essential oils. The genus is rich in several types of bioactive coumarin compounds, with huge potential for the discovery of new coumarins. Various parts of these plants produce essential oils (mainly aliphatic esters and monoterpenes) with a wide spectrum of biological activities. Heracleum species have great potential for applications in the food, cosmetics, perfumery, and pharmaceutical industries due to their broad ethnobotanical uses and pharmacological properties. Accordingly, this review aims to categorize updated and comprehensive information on ethnobotanical uses, phytochemistry, and pharmacology of Heracleum species in order to open new perspectives for future studies, including possible uses as functional ingredients in food products.

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Chemical Composition and Antimicrobial Activity of Essential Oil of Heracleum rigens

Cited by 5 publications

References 9 publications

Antibacterial Activity of the Essential Oil of Heracleum Sibiricum

Antibacterial Activity of the Essential Oil of Heracleum Sibiricum

Absolute quantification of terpenes in conifer-derived essential oils and their antibacterial activity

The Genus Heracleum: A Comprehensive Review on Its Phytochemistry, Pharmacology, and Ethnobotanical Values as a Useful Herb

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