Chemical composition and antimicrobial activity of the essential oil of Coriandrum sativum

Matasyoh, Josphat C.; Maiyo, Zipporah Chelagat; Ngure, R. M.; Chepkorir, Regina

doi:10.1016/j.foodchem.2008.07.097

Cited by 206 publications

(153 citation statements)

References 14 publications

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“…O OEOg foi obtido por destilação por arraste a vapor em aparelho tipo Clevenger e a análise dos constituintes químicos foi realizada no Parque de Desenvolvimento Tecnológico do Ceará (PADETEC -UFC), em cromatógrafo gasoso acoplado à espectrometria de massa (CG-EM) (Matasyoh et al 2007). Tween 80 a 1% foi utilizado como solvente do OEOg.…”

Section: Extração E Análise Do Oeogunclassified

“…Para isso, o crescimento microbiano foi acompanhado pela contagem de colônias em meio sólido após 2, 4,6,8,10,12,24,28, 32 e 48 h (Sales, 2014). Para determinar o efeito do tempo de exposição ao OEOg sobre a viabilidade celular de cepas de Candida foi seguida a metodologia descrita por Matasyoh et al (2007), com algumas modificações. Alíquotas de 20 µL de OEOg, em CIM, foram adicionadas a poços de microplacas de 96 poços contendo 100 µL de CSD e 80 µL de uma suspensão microbiana (10 4 UFC/mL).…”

Section: Avaliação Da Atividade Antifúngica Do Oeogunclassified

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Atividade antifúngica e possível mecanismo de ação do óleo essencial de folhas de Ocimum gratissimum (Linn.) sobre espécies de Candida

Oliveira

Batista

Fernandes

et al. 2016

Rev. bras. plantas med.

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RESUMO:A espécie Ocimum gratissimum (Linn.), popularmente conhecida como alfavacacravo, é muito utilizada na medicina popular. A planta apresenta inúmeros compostos, sendo o eugenol o constituinte majoritário do seu óleo essencial e o provável responsável pela sua atividade antimicrobiana. O objetivo deste estudo foi determinar o potencial antifúngico e o possível mecanismo de ação do óleo essencial extraído das folhas de O. gratissimum L. (OEOg) sobre cepas-padrão de Candida. Para avaliação da atividade antimicrobiana foi determinada a Concentração Inibitória Mínima (CIM), o efeito do tempo de exposição, o efeito modulador na atividade de antifúngicos (ATF) de uso clínico e a ação do OEOg nas fases de crescimento exponencial e estacionário de leveduras do gênero Candida. O mecanismo de ação do OEOg foi verificado por captação do cristal violeta e avaliação da morfologia microbiana pela técnica de microcultivo. Também foi avaliada a toxicidade do OEOg sobre hemácias humanas. O OEOg apresentou boa atividade antifúngica sobre cepas de Candida, sendo capaz de reduzir a taxa de crescimento das cepas de Candida a partir de quatro horas de exposição, além de ter modulado positivamente a atividade do cetoconazol para C. tropicalis ATCC 13803 e reduzir o número de células viáveis em todas as fases de crescimento microbiano. O OEOg foi capaz de promover o aumento discreto da captação do cristal violeta e provocou alterações na micromorfologia das células de Candida spp., sugerindo que seu alvo de ação seja o envoltório celular. Observou-se baixa toxicidade do OEOg sobre hemácias humanas. Os resultados encontrados mostraram que o OEOg possui boa atividade sobre o gênero Candida, com mecanismo de ação mediado possivelmente pela ocorrência de danos no envoltório celular, além de ter sido observada baixa toxicidade, indicando do OEOg é promissor no desenvolvimento e elaboração de um novo fármaco com potencial atividade para o tratamento de doenças fúngicas. Palavras-chave:Ocimum, óleos essenciais, atividade antimicrobiana, farmacologia. ABSTRACT: Antifungal activity and potential action mechanisms of essential oil ofOcimum gratissimum (Linn.) leaves against Candida species. Ocimum gratissimum (Linn.) is a medicinal plant popularly known as "wild basil" widely used in traditional medicine. The plant has numerous compounds, and eugenol is the major constituent of its essential oil and likely responsible for its antimicrobial activity. The aim of this study was to determine the antifungal activity and the potential mechanism of action of the essential oil extracted from the leaves of O. gratissimum L. (OEOg) against standard strains of Candida. The following experiments were performed: determination of Minimum Inhibitory Concentration (MIC), determination of the effect of exposure time to OEOg; evaluation of the modulating effect of OEOg in antifungal (ATF) activity for clinical use; determination of the effects of the OEOg on different growth phases of Candida spp; determination of crystal violet (CV) uptake and the microcultu...

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Section: Extração E Análise Do Oeogunclassified

Section: Avaliação Da Atividade Antifúngica Do Oeogunclassified

Atividade antifúngica e possível mecanismo de ação do óleo essencial de folhas de Ocimum gratissimum (Linn.) sobre espécies de Candida

Oliveira

Batista

Fernandes

et al. 2016

Rev. bras. plantas med.

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“…Biogenic nanoparticles can be formed by both intra and extra-cellular methods. If nanoparticles are produced extra-cellularly, the extraction would be easier and amount of nanoparticles produced could be massive [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Water Extract of Piper Nigrum Seed Assisted Synthesis of Silver Nanoparticles and Reduction of Various Nitro Compounds by NaBH4 in the Presence of AgNPs as a Catalyst

2018

Chem Sci Trans

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An attempt has been made for eco-friendly synthesis of silver nanoparticles by water extract of Piper nigrum seed. Formation of AgNPs and their morphology was confirmed by using different advanced characterization techniques such as UV-Visible spectroscopy, XRD and FE-SEM images of AgNPs. Further we wish to report for the first time reduction of various nitro compounds to corresponding amines by NaBH 4 in the presence of AgNPs as a catalyst. After reaction course, AgNPs can be recycled and reused without any apparent loss of activity which makes this process cost effective and hence eco-friendly. The structures of all the corresponding reduced products were confirmed by comparing their IR, 1 H NMR, spectra with the authentic samples.

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“…Traditionally, all parts of the plant are used to alleviate gastrointestinal complaints, bronchitis, muscular spasm, gout, and rheumatoid disorders (16). Several studies performed on this herb reported that the plant has various therapeutic properties, including, anti-microbial, anti-hyperlipidemia, hepato-protective, anti-peroxidative, insulin-releasing, and insulin-like activity (17)(18)(19)(20). Various polyphenol and flavonoid compounds, including glycitin, caffeic acid, protocatechuic acid, apigenin, Aliphatic (2E)-alkenals, and alkanals were reported in the aerial parts of C. sativum (21-23) whereas, Quercetin 3-glucuronide, isoquercitrin, and rutin were found in the fruit (24).…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Hydro-Alcoholic Extract of Coriandrum sativum in Rats with Experimental Iron-Overload Condition

Talaei

Kheirollah

Babaahmadi‐Rezaei

et al. 2017

Jundishapur J Nat Pharm Prod

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Background: Development of a new iron-chelating medication may eventually serve as treatment of iron overload diseases, such as thalassemia and other iron related disorders. Coriander sativum, a plant rich of phenol and flavonoids, has an iron-chelating effect in-vitro. The ethanolic extract of C. sativum was investigated for its in-vivo ameliorating effect on hepatic damage in rats with experimental iron overload. Methods: Twenty-four adult male wistar rats were randomly divided to 4 groups: healthy control, iron overload, iron overload treated with deferoxamine, and 200 mg/kg of C. sativum extract, respectively. Assessments were performed for serum iron, ferritin, and serum markers of hepatic and cardiac damages, antioxidant enzyme, and lipid peroxidation levels. Results:The results indicated serum iron and ferritin concentration were significantly increased in the iron overload group compared to healthy controls (P < 0.05). Treatment with C. sativum extract significantly decreased iron and ferritin concentration (P < 0.05). Histopathological changes in the liver, kidney, and the cardiac system, and iron accumulation in the liver were observed in the iron overload group compared to healthy controls (P < 0.05). Treatment with C. sativum extract significantly decreased biochemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and Creatinine phosphokinase (CPK), and improved tissue damage and decreased iron accumulation in the liver compared to the iron overload group (P < 0.05). Conclusions:The study showed that the hydro-alcoholic extract of C. sativum has iron-chelating and liver protective effects similar to deferoxamine against experimental iron overload condition in rats.

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Chemical composition and antimicrobial activity of the essential oil of Coriandrum sativum

Cited by 206 publications

References 14 publications

Atividade antifúngica e possível mecanismo de ação do óleo essencial de folhas de Ocimum gratissimum (Linn.) sobre espécies de Candida

Atividade antifúngica e possível mecanismo de ação do óleo essencial de folhas de Ocimum gratissimum (Linn.) sobre espécies de Candida

Water Extract of Piper Nigrum Seed Assisted Synthesis of Silver Nanoparticles and Reduction of Various Nitro Compounds by NaBH4 in the Presence of AgNPs as a Catalyst

The Protective Effects of Hydro-Alcoholic Extract of Coriandrum sativum in Rats with Experimental Iron-Overload Condition

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