Chemical composition and antinociceptive and anti-inflammatory activity of the essential oil of Hyptis crenata Pohl ex Benth. from the Brazilian Amazon

Lima, Maria Nancy N. de; Guimarães, Bruna A.; Castro, Ana Lídia S. de; Ribeiro, Kevellen B.; Miller, Daniele C.; Silva, Pedro Iuri C. da; Freitas, J. J. S.; Lima, Anderson Bentes de; Setzer, William N.; Silva, Joyce Kelly R. da; Maia, José Guilherme S.; Figueiredo, Pablo Luis B.

doi:10.1016/j.jep.2022.115720

Cited by 9 publications

(10 citation statements)

References 31 publications

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“…Leukocyte migration has the role of recognizing and neutralizing foreign agents/aggressors, thus being an important step in the development of the inflammatory process ( Kumar et al, 2014 ). The decrease in cell migration indicates the anti-inflammatory activity of new substances ( de Jesus et al, 2023 ; de Lima et al, 2023 ). The results demonstrate that P. heyneanus essential oil did not have an acute anti-inflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil

Santos,

Jerônimo,

Ribeiro

et al. 2024

Front. Pharmacol.

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Background:Pogostemon heyneanus leaves infusions are relevant in ethnopharmacology for treating colds, coughs, headaches, and asthma.Purpose: The essential oil chemical composition of a Pogostemon heyneanus specimen was monthly monitored from October 2021 to July 2022 to evaluate the climatic influences on its yield and chemical composition and antinociceptive, andanti-inflammatory properties.Methods: The leaves, collected monthly over a 10-month period, were submitted to hydrodistillation. The oils obtained were analyzed by gas chromatography coupled to a mass spectrometer and gas chromatography coupled to flame ionization detector. The P. heyneanus essential oil (PhEO) was tested in vivo to evaluate its peripheral analgesic actions through the abdominal writhing test induced by acetic acid, and peripheral analgesia by tail immersion. Neurogenic and inflammatory pain were evaluated by formalin test, and acute oral toxicity of the oil was also verified.Results: PhEO presented 27 chemical constituents with the highest predominance of patchoulol (43.6%–76.9%), α-bulnesene (0.2%–12.7%), α-guaiene (0.4%–8.9%), seychellene (3.8%–5.1%) and pogostol (0.0%–8.2%). The climatic parameters insolation, humidity, rainfall, and temperature did not influence the essential oil yield or the main chemical constituents, except for pogostol, which presented a strong (r = 0.73) and statistically significant (p < 0.05) correlation with temperature. PhEO did not display toxicity at the maximum 300 mg/kg dosage. The oil showed low peripheral and central analgesic action at 100 mg/kg, while in the neurogenic and inflammatory pain inhibition tests, no actions related to PhEO were observed. In the carrageenan-induced peritonitis test, PhEO did not reduce the migration of leukocytes to the peritoneal cavity compared to the control group.Conclusion:Pogostemon heyneanus is a resistant plant to seasonal influences and a source of patchoulol. Despite ethnopharmacological indications, no in-vivo biological activities such as neurogenic or inflammatory pain were identified in the present work. So, the low influence of the climatic parameters on chemical composition can infer that the low pharmacological activity is also not subject to climatic variations, that is, it does not change due to the climate.

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Section: Discussionmentioning

confidence: 99%

Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil

Santos,

Jerônimo,

Ribeiro

et al. 2024

Front. Pharmacol.

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“…In the first 5 min, the nociception observed is due to direct stimulation of sensory terminals, corresponding to the neuropathic component of the test. In this phase, the modulation of nociception has been linked mainly to drugs capable of interfering with neural mechanisms that conduct the noxious stimulus, such as opioids, anticonvulsants, and antidepressants, among others [ 23 , 27 , 29 ]. MnE did not promote alterations in the neuropathic component of formalin-induced nociception, indicating that its constituent probably does not act on nervous components.…”

Section: Discussionmentioning

confidence: 99%

“…MnE did not promote alterations in the neuropathic component of formalin-induced nociception, indicating that its constituent probably does not act on nervous components. A 10-minute hiatus is observed in the formalin test, which is followed by a new period (15–30 min) of nociceptive manifestation, now caused by an inflammatory process triggered by formalin aggression, which involves prostaglandins, histamine, serotonin, and NO and plasma leakage [ 29 , 30 ]. MnE (400 mg/kg) significantly reduced formalin-induced inflammatory nociception.…”

Section: Discussionmentioning

confidence: 99%

Margaritaria nobilis L.f. (Phyllanthaceae) Ethanolic Extract: Low Acute Oral Toxicity and Antinociceptive Activity

et al. 2023

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Margaritaria nobilis L.f. (Phyllanthaceae), a native Brazilian tree occurring mainly in the Amazon, is used in folk medicine for the treatment of abscesses (bark) and cancer-like symptoms (leaves). The present study evaluates the safety of its acute oral administration and its effects on nociception and plasma leakage. The chemical constitution of the leaf’s ethanolic extract is determined by ultra-performance liquid chromatography–high-resolution mass spectrometry (LC-MS. Its acute oral toxicity is evaluated in female rats at a dose of 2000 mg/kg, evaluating the occurrence of deaths and Hippocratic, behavioral, hematological, biochemical, and histopathological changes, as well as food and water consumption and weight gain. Antinociceptive activity is evaluated in male mice with acetic-acid-induced peritonitis (APT) and formalin (FT) tests. An open field (OF) test is performed to verify possible interferences in the animals’ consciousness or locomotion. LC-MS analysis shows the presence of 44 compounds classified as phenolic acid derivatives, flavonoids and O-glycosylated derivatives, and hydrolyzable tannins. No deaths or significant behavioral, histological, or biochemical changes are observed in the toxicity assessment. In nociception tests, M. nobilis extract significantly reduces abdominal contortions in APT, demonstrating selectivity for inflammatory components (FT second phase), not interfering in neuropathic components (FT first phase) or consciousness and locomotion levels in OF. Additionally, M. nobilis extract inhibits plasma acetic-acid-induced leakage. These data demonstrate the low toxicity of M. nobilis ethanolic extract, as well as its effectiveness in modulating inflammatory nociception and plasma leakage, possibly related to the flavonoids and tannins present in its composition.

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“…The oils were dehydrated with anhydrous Na 2 SO 4 , and the total oil yields were expressed in mL/100 g of dry material. [44]…”

Section: Plant Materials and Essential Oil Extractionmentioning

confidence: 99%

Siparuna guianensis Essential Oil Antitumoral Activity on Ehrlich Model and Its Effect on Oxidative Stress

Viana Barbosa,

Silva de Jesus,

Botelho Jerônimo

et al. 2023

Chemistry & Biodiversity

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This work aims to evaluate the chemical composition, in vitro antioxidant capacity, and in vivo antitumoral activity of S. guianensis essential oil against Ehrlich's ascitic carcinoma and the effects on oxidative stress. The animals (Mus musculus) received a daily dose of S. guianensis oil orally (100 mg/kg) for 9 days. The main constituents of essential oil were curzerenone (16.4±1.5 %), drimenol (13.7±0.2 %), and spathulenol (12.4±0.8 %). S. guianensis oil showed antioxidant activity, inhibiting 11.1 % of DPPH radicals (95.7 mgTE/g); and 15.5 % of the β‐carotene peroxidation. The group treated with S. guianensis showed a significant reduction in tumor cells (59.76±12.33) compared to the tumor group (96.88±19.15). Essential oil of S. guianensis decreased MDA levels and increased SOD levels in liver tissue. The essential oil of S. guianensis reduced oxidative stress, and showed antitumor and antioxidant activity, being characterized as a new chemical profile in the investigation of pathologies such as cancer.

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Chemical composition and antinociceptive and anti-inflammatory activity of the essential oil of Hyptis crenata Pohl ex Benth. from the Brazilian Amazon

Cited by 9 publications

References 31 publications

Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil

Exploring the impact of seasonal variations on the chemical composition, antinociceptive, and anti-inflammatory properties of Pogostemon heyneanus Benth. essential oil

Margaritaria nobilis L.f. (Phyllanthaceae) Ethanolic Extract: Low Acute Oral Toxicity and Antinociceptive Activity

Siparuna guianensis Essential Oil Antitumoral Activity on Ehrlich Model and Its Effect on Oxidative Stress

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