Chemical Composition and Antioxidant Properties of Different Combinations of Submerged Cultured Mycelia of Medicinal Mushrooms

Huang, Chi‐Wei; Hung, Yu‐Ching; Chen, Liangyin; Asatiani, Mikheil D.; Elisashvili, Vladimir; Klarsfeld, Gadi; Melamed, Dobroslav; Fares, Basem; Wasser, Solomon P.; Mau, Jeng‐Leun

doi:10.1615/intjmedmushrooms.2021039339

Cited by 8 publications

(3 citation statements)

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“…The ME were prepared according to the method described before (Huang et al, 2021) [ 36 ]. Briefly, mixtures of mycelial powders were used for the extraction of bioactive compounds; distilled water was used for hot water extraction; dry powder of mycelial biomass was extracted for 3 h with distilled H 2 O (1 g/10 mL proportion) at 80 °C using (Shaking Water Bath, (MRC, Holon, Israel).…”

Section: Methodsmentioning

confidence: 99%

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The Effect of Natural-Based Formulation (NBF) on the Response of RAW264.7 Macrophages to LPS as an In Vitro Model of Inflammation

Monga

Fares²,

Yashaev

et al. 2022

JoF

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Macrophages are some of the most important immune cells in the organism and are responsible for creating an inflammatory immune response in order to inhibit the passage of microscopic foreign bodies into the blood stream. Sometimes, their activation can be responsible for chronic inflammatory diseases such as asthma, tuberculosis, hepatitis, sinusitis, inflammatory bowel disease, and viral infections. Prolonged inflammation can damage the organs or may lead to death in serious conditions. In the present study, RAW264.7 macrophages were exposed to lipopolysaccharide (LPS; 20 ng/mL) and simultaneously treated with 20 µg/mL of natural-based formulation (NBF), mushroom–cannabidiol extract). Pro-inflammatory cytokines, chemokines, and other inflammatory markers were analyzed. The elevations in the presence of interleukin-6 (IL-6), cycloxygenase-2 (COX-2), C-C motif ligand-5 (CCL5), and nitrite response, following exposure to LPS, were completely inhibited by NBF administration. IL-1β and tumor necrosis factor alpha (TNF-α) release were inhibited by 3.9-fold and 1.5-fold, respectively. No toxic effect of NBF, as assessed by lactate dehydrogenase (LDH) release, was observed. Treatment of the cells with NBF significantly increased the mRNA levels of TLR2, and TLR4, but not NF-κB. Thus, it appears that the NBF possesses anti-inflammatory and immunomodulatory effects which can attenuate the release of pro-inflammatory markers. NBF may be a candidate for the treatment of acute and chronic inflammatory diseases and deserves further investigation.

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Section: Methodsmentioning

confidence: 99%

“…After extraction, insoluble solid compounds were separated by centrifugation at 6000 rpm at 4 °C for 15 min followed by filtration through the Whatman filter paper N 1. Filtrates were evaporated using a vacuum evaporator and finally dried at 40 °C in an air-forced laboratory oven [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

The Effect of Natural-Based Formulation (NBF) on the Response of RAW264.7 Macrophages to LPS as an In Vitro Model of Inflammation

Monga

Fares²,

Yashaev

et al. 2022

JoF

Self Cite

View full text Add to dashboard Cite

show abstract

“…Also, the above-mentioned activity was studied for aqueous, hydroethanolic and ethanolic extracts from Lentinus squarrosulus, the later exhibiting the greatest activity (Eyi Ndong et al, 2021). The antioxidant activity was evaluated after a combination of mushrooms observing a positive effect in the properties (Huang et al, 2021a). Anguloye (2021) explored the bioactivity of the aqueous extracts from P. ostreatus and Lentinus subnudus observing antioxidant and antihypertensive properties, more potent in the second mushroom.…”

Section: Bioactive Properties From Mushroomsmentioning

confidence: 99%

Update on potential of edible mushrooms: high‐value compounds, extraction strategies and bioactive properties

López‐Hortas

Flórez‐Fernández

Torres

et al. 2022

Int J of Food Sci Tech

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The traditional and growing importance of mushrooms due to their rich composition in nutritive and bioactive compounds converts the whole feedstock and their fractions into versatile attractive ingredients for food and nutraceuticals. The processing conditions are critically relevant to selectively recover highvaluable compounds in a sustainable way. This short review, covering scientific papers published in the last 2 years, offers an updated vision of the study and applications of edible mushroom bioactive compounds, covering aspects in relation to the novelties in the cultivation, isolation, identification, characterisation of chemical and biological properties, extraction technologies and purification, as well as food applications, particularly in novel foods.

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Antioxidant Activities of Hot Water Extracts from Mycelial Biomass of Different Combinations of Medicinal Agaricomycetes Mushrooms

Huang

Hung

Chen

et al. 2022

Int J Med Mushrooms

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Chemical Composition and Antioxidant Properties of Different Combinations of Submerged Cultured Mycelia of Medicinal Mushrooms

Cited by 8 publications

References 0 publications

The Effect of Natural-Based Formulation (NBF) on the Response of RAW264.7 Macrophages to LPS as an In Vitro Model of Inflammation

The Effect of Natural-Based Formulation (NBF) on the Response of RAW264.7 Macrophages to LPS as an In Vitro Model of Inflammation

Update on potential of edible mushrooms: high‐value compounds, extraction strategies and bioactive properties

Antioxidant Activities of Hot Water Extracts from Mycelial Biomass of Different Combinations of Medicinal Agaricomycetes Mushrooms

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