Chemical composition and biological activities of the essential oil from Cleome rutidosperma DC

McNeil, Megil J.; Porter, Richard J.; Rainford, Lois; Dunbar, Oliver R. A.; Francis, Sheena; Laurieri, Nicola; Delgoda, Rupika

doi:10.1016/j.fitote.2018.07.006

Cited by 14 publications

(11 citation statements)

References 37 publications

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“…Table 1 shows the identification of the constituents by comparason of their mass spectral data with those available in the NIST 08 (NIST Match Factor of 850), Wiley-275 (Hewlett Packard) and Wiley/NBS libraries and in the literature. The identification of the hydrocarbons, 1-pentadecene (1) and 1-heptadecene (3) was based on the NIST MS spectral database and data reported by Siddiquee et al (2015) and by McNeil et al (2018). The compound 2,4-di-tert-butylphenol (2) exhibited molecular ions M +•) at m/z 206 and a base peak at m/z 191, indicating the loss of a methyl group, and was identified based on data reported by Kusch et al (2011) and by Irawan et al (2018).…”

Section: Resultsmentioning

confidence: 99%

Cardanols detected in non-polar propolis extracts from Scaptotrigona aff. postica (Hymenoptera, Apidae, Meliponini)

Negri

Silva

Coelho

et al. 2019

Braz. J. Food Technol.

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The propolis produced by stingless bees of the tribe Meliponini is a viscous product that contains the resin collected from buds, leaves and plant exudates, mixed with salivary secretions, wax and soil. The species Scaptotrigona aff. postica (Latreille, 1807), (Hymenoptera, Apidae, Meliponinae) popularly known as “tubi” in Maranhão State, Brazil, does not mix soil to produce its propolis. The propolis from S. postica harvested in Barra do Corda, Maranhão State, is popularly used in the treatment of wounds and respiratory illnesses. The hydroalcoholic extract of this propolis, rich in flavone-6,8-di-C-glycosides (vicenin-2 and schaftoside), pyrrolizidine alkaloids derived from retronecine, catechin and caffeoylquinic acid derivatives exhibited antiviral activity against the herpes simplex and rubella viruses. The aim of this study was to increase knowledge about the chemical composition of the S. postica propolis by analyzing non-polar extracts obtained using hexane and chloroform as the solvents, by GC-EI-MS. A total of 15 constituents were identified comparing their respective mass spectral data with those available in the NIST data bases and those reported in the literature. The main constituents detected were the phenolic lipids, known as cardanols, 3-(4,7-heptadecadienyl) phenol (5), 3-(10-heptadecenyl) phenol (7), 3-heptadecylphenol (9) and 3-pentadecyl phenol or hydrocardanol (13), which predominated in the hexane extract, while the predominant constituents in the chloroform extract were 3-pentadecyl phenol or hydrocardanol (13) and 3-(8-pentadecenyl) phenol (12). The antioxidant, antitumoral, antifeedant, cytotoxic, anticarcinogenic, antiproliferative, antimicrobial, antileishmanial and larvicidal activities of the cardanols have been demonstrated in many studies.

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Section: Resultsmentioning

confidence: 99%

Cardanols detected in non-polar propolis extracts from Scaptotrigona aff. postica (Hymenoptera, Apidae, Meliponini)

Negri

Silva

Coelho

et al. 2019

Braz. J. Food Technol.

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“…Our results corroborate the findings of Jin et al [32], who found that amyrin acetate isolated from the leaves and twigs of Acer okamotoanum Nakai family Aceraceae exhibited a significant inhibitory effect on activation of the classical pathway. The diterpene phytol was identified as the most abundant compound of Cleome rutidosperma DC family Cleomaceae aerial essential oil and exhibited antimicrobial activity against pathogenic bacteria and fungus strain [33]. Finally, diterpene phytol was shown also to decrease autoimmune response in both acute and chronic phases of experimental arthritis [27], as well as phytol attenuates the inflammatory response in paw edema model by inhibiting neutrophil migration, reducing inflammatory cytokines levels and oxidative stress [34].…”

Section: Discussionmentioning

confidence: 99%

Supercritical Extracts from Arctium lappa as a Potential Inhibitor for the Activation of Complement System

Fontana

Bavia

Bovo

et al. 2019

PMIO

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Arctium lappa is a perennial species of the Asteraceae family originally from Europe and Asia. Considered a weed species in the southern region of Brazil, it is popularly used as a natural anti-inflammatory. The complement system is an important component of the innate immune response. However, its exacerbated activation can lead to harmful conditions like autoimmune and inflammatory disorders. Plants that inhibit the activation of complement can be a promising tool in the treatment of inflammatory diseases. Here, we evaluated the effect of A. lappa leaves extracts on the activation of the classical and alternative pathways of complement system. Two extracts were obtained under supercritical conditions using scCO2 with ethanol as cosolvent, at 313.15K, 15 MPa (E1) and 25 MPa (E2). Classical and alternative activation were evaluated using complement fixation test. Different concentrations of A. lappa extracts E1 and E2 showed an inhibitory effect on both complement pathways, and heparin was used as control. The IC50 of E1, E2, and heparin were 28.26, 20.12 and 92.54 µg/mL for classical and 26.12, 27.70, 27.78 µg/mL for the alternative pathway. Results demonstrate that A. lappa is a promising complementary treatment for diseases associated with complement activation.

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“…Furthermore, lupeol isolated from Lonchocarpus araripensis attenuated allergic airway inflammation in mice . The phytol, a diterpenoid, was identified as the most abundant compound in essential oil obtained from the aerial parts of Cleome rutidosperma , Leonotis nepetaefolia and Cleome serrata and exhibited antimicrobial activity. The phytol extracted from Justicia gendarussa has shown potent anti‐inflammatory activity by inhibiting histamine, bradykinin and prostaglandin when compared to standard diclofenac in a rat paw edema model .…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Supercritical Extracts from Arctium lappa L. on the Lectin Pathway of the Complement System

Bavia

Fontana

Bovo

et al. 2019

Chemistry & Biodiversity

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The complement system participates in host defense by eliminating microorganisms and triggering inflammation. However, insufficient control or exacerbated complement activation contributes to inflammatory diseases. Since promising antioxidant and anti-inflammatory activities have been identified in Arctium lappa L. extracts, this study aims to explore the effect of A. lappa extracts on the lectin pathway (LP) of complement activation. Four extracts were obtained by supercritical extraction using scCO 2 with or without ethanol as cosolvent, at different temperatures and pressures (E1: 2.2 mg/mL, E2: 2.6 mg/mL and E3: 2.0 mg/mL, E4: 1.5 mg/ mL). To evaluate the effect of A. lappa extracts on the LP activation, an ELISA assay using mannose binding lectin pathway of complement was carried out with C4 detection. All extracts showed a concentration-dependent inhibitory effect on the activation of complement by the LP. The following IC 50 were observed for E1, E2, E3 and E4: 179.4 μg/mL, 74.69 μg/mL, 119.1 μg/mL and 72.19 μg/mL, respectively. Our results suggest that A. lappa extracts are potential candidates for the treatment of inflammatory disorders that are complement-related. ResultsThe A. lappa extracts E1, E2, E3 and E4 displayed an inhibitory effect on the functional activity of lectin pathway (Figure 1). The extract E1 (at concentration Figure 1. Effect of Arctium lappa L. extracts on functional activity of the MBL lectin pathway of complement system. The activation of the lectin pathway was evaluated in the presence of four extracts obtained under different conditions: The extracts E1 and E2 were obtained using scCO 2 in the presence (A) and absence of ethanol (B) as co-solvent, respectively, at 200 bar and 60°C. The extract E3 was obtained using scCO 2 + ethanol at 150 bar and 80°C (C). The extract E4 was obtained using scCO 2 + ethanol at 250 bar and 80°C (D). The final concentration of all extracts evaluated is represented in the x axis. All extracts dilutions were compared with the positive control (NHS diluted to represent 50 % of lectin pathway activation) by one-way ANOVA and Bonferroni's multiple comparison test (***p < 0.001, **p < 0.01, and *p < 0.05). All biological experiments were performed twice in duplicate and the results were expressed as mean and standard deviation.

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Chemical composition and biological activities of the essential oil from Cleome rutidosperma DC

Cited by 14 publications

References 37 publications

Cardanols detected in non-polar propolis extracts from Scaptotrigona aff. postica (Hymenoptera, Apidae, Meliponini)

Cardanols detected in non-polar propolis extracts from Scaptotrigona aff. postica (Hymenoptera, Apidae, Meliponini)

Supercritical Extracts from Arctium lappa as a Potential Inhibitor for the Activation of Complement System

Inhibitory Effect of Supercritical Extracts from Arctium lappa L. on the Lectin Pathway of the Complement System

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