Chemical composition and biological activities of Jeju Thymus quinquecostatus essential oils against Propionibacterium species inducing acne

Oh, Tae-Heon; Kim, Sang Suk; Yoon, Weon‐Jong; Kim, Jiyoung; Yang, Eun Jin; Lee, Nam Ho; Hyun, Chang‐Gu

doi:10.2323/jgam.55.63

Cited by 27 publications

(19 citation statements)

References 30 publications

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“…Backhousia citriodora oil at a concentration of 1.00% showed low toxicity to human skin cells and skin fibroblasts [115], whereas neat B. citriodora oil and citral were shown to be toxic to human skin cells (F1-73) and skin fibroblasts [115]. Thymus quinquecostatus , w hen tested against fibroblast cells for cytotoxicity, showed low cytotoxicity at concentrations below 12.5 μ g/mL in fibroblast cells and thus may be suitable for topical treatment [207]. Mentha piperita is one of the most popularly used essential oils [372]; however, there have been reports that M. piperita oil can cause both dermal irritations [356].…”

Section: Essential Oil Toxicitymentioning

confidence: 99%

Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases

Orchard

Vuuren

2017

Evidence-Based Complementary and Alternative Medicine

184

121

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Essential oils are one of the most notorious natural products used for medical purposes. Combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. At least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. This review explores the fundamental knowledge available on the antimicrobial properties against pathogens responsible for dermatological infections and compares the scientific evidence to what is recommended for use in common layman's literature. Also included is a review of combinations with other essential oils and antimicrobials. The minimum inhibitory concentration dilution method is the preferred means of determining antimicrobial activity. While dermatological skin pathogens such as Staphylococcus aureus have been well studied, other pathogens such as Streptococcus pyogenes, Propionibacterium acnes, Haemophilus influenzae, and Brevibacterium species have been sorely neglected. Combination studies incorporating oil blends, as well as interactions with conventional antimicrobials, have shown that mostly synergy is reported. Very few viral studies of relevance to the skin have been made. Encouragement is made for further research into essential oil combinations with other essential oils, antimicrobials, and carrier oils.

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Section: Essential Oil Toxicitymentioning

confidence: 99%

Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases

Orchard

Vuuren

2017

Evidence-Based Complementary and Alternative Medicine

184

121

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“…It also induces low cytotoxicity in human cell lines proving itspossible effectiveness for acne treatment [80]. Additionally, antibacterial activity of rosemary essential oil against P. acnes (MIC 0.56 mg/mL) was probably attributed to its bioactive components such as 1,8-cineole, α -pinene, camphor, and camphene.…”

Section: Plants Having Antiacne Potentialmentioning

confidence: 99%

New Perspectives on Antiacne Plant Drugs: Contribution to Modern Therapeutics

Sinha

Srivastava

Mishra

et al. 2014

BioMed Research International

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Acne is a common but serious skin disease, which affects approximately 80% adolescents and young adults in 11–30 age group. 42.5% of men and 50.9% of women continue to suffer from this disease into their twenties. Bacterial resistance is now at the alarming stage due to the irrational use of antibiotics. Hence, search for new lead molecule/bioactive and rational delivery of the existing drug (for better therapeutic effect) to the site of action is the need of the hour. Plants and plant-derived products have been an integral part of health care system since time immemorial. Therefore, plants that are currently used for the treatment of acne and those with a high potential are summarized in the present review. Most active plant extracts, namely, P. granatum, M. alba, A. anomala, and M. aquifolium exhibit minimum inhibitory concentration (MIC) in the range of 4–50 µg/mL against P. acnes, while aromatic oils of C. obovoides, C. natsudaidai, C. japonica, and C. nardus possess MICs 0.005–0.6 μL/mL and phytomolecules such as rhodomyrtone, pulsaquinone, hydropulsaquinone, honokiol, magnolol, xanthohumol lupulones, chebulagic acid and rhinacanthin-C show MIC in the range of 0.5–12.5 μg/mL. Novel drug delivery strategies of important plant leads in the treatment of acne have also been discussed.

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“…Thymus spp. also produce secondary metabolites that can be used as antioxidants, expectorants, antitussives, antiplatelet drugs, antimicrobials and drugs for the treatment of skin disorders (Dandlen et al, 2010;Faleiro et al, 2003;Figueiredo et al, 2008;Hazzit, Baaliouamer, Veríssimo, Faleiro, & Miguel, 2009;Oh et al, 2009;Okazaki, Kawazoe, & Takaishi, 2002). Thymus lotocephalus G. López & R. Morales is an aromatic species endemic to the Algarve region, which blossoms from April to June and is typically found in dry open areas and scrublands (Figueiredo et al, 2001(Figueiredo et al, , 2008.…”

Section: Introductionmentioning

confidence: 99%