Chemical Composition and Biological Activities of Essential Oil from Aerial Parts of <i>Frankenia pulverulenta</i> L. and <i>Boerhavia elegans</i> Choisy from Northern Oman

Rehman, Najeeb Ur; Al-Sabahi, Jamal Nasser; Alam, Tanveer; Rafiq, Kashif; Khan, Ajmal; Hidayatullah,; Khan, Nasir; Khan, Abdul Latif; Ruqaishi, Houda Al; Al‐Harrasi, Ahmed

doi:10.1080/0972060x.2021.1978870

Cited by 8 publications

(16 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The essential oils extracted through hydro-distillation from the leaves and stem of the B. hirtum yielded 1.2 g (0.052%) and 0.95 g (0.045%), respectively, using a Clevenger-type apparatus (three times for at least 6 h) and were observed to be yellow-colored [ 14 , 15 ]. A known quantity of the EOs was collected, dried over anhydrous sodium sulfate (Na 2 SO 4 ), and kept in the refrigerator at 4 °C until further GC-MS analysis and in vitro antidiabetic and cytotoxic assays.…”

Section: Methodsmentioning

confidence: 99%

“…Some of the compounds were identified by comparing their mass spectra with the MS library database (NIST 2011 v.2.3). Compound identification was also made possible by comparing their retention times (Rt) with those of the pure authentic samples and by means of their retention index (RI), relative to the series of n-hydrocarbons [ 14 , 15 , 16 ].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

First Report on Comparative Essential Oil Profile of Stem and Leaves of Blepharispermum hirtum Oliver and Their Antidiabetic and Anticancer Effects

et al. 2022

View full text Add to dashboard Cite

The current research was designed to explore the Blepharispermum hirtum Oliver (Asteraceae) stem and leaves essential oil (EO) composition extracted through hydro-distillation using gas chromatography-mass spectrometry (GC-MS) analysis for the first time. The EOs of the stem and leaves of B. hirtum were comparatively studied for the in vitro antidiabetic and anticancer potential using in vitro α-glucosidase and an MTT inhibition assay, respectively. In both of the tested samples, the same number of fifty-eight compounds were identified and contributed 93.88% and 89.07% of the total oil composition in the EOs of the stem and leaves of B. hirtum correspondingly. However, camphene was observed as a major compound (23.63%) in the stem EO, followed by β-selinene (5.33%) and β-elemene (4.66%) and laevo-β-pinene (4.38%). While in the EO of the leaves, the dominant compound was found to be 24-norursa-3,12-diene (9.08%), followed by β-eudesmol (7.81%), β-selinene (7.26%), thunbergol (5.84%), and caryophyllene oxide (5.62%). Significant antidiabetic potential was observed with an IC50 of 2.10 ± 0.57 µg⁄mL by the stem compared to the EO of the leaves of B. hirtum, having an IC50 of 4.30 ± 1.56 µg⁄mL when equated with acarbose (IC50 = 377.71 ± 1.34 µg⁄mL). Furthermore, the EOs offered considerable cytotoxic capabilities for MDA-MB-231. However, the EO of the leaves presented an IC50 = 88.4 ± 0.5 μg/mL compared to the EO of the stem of B. hirtum against the triple-negative breast cancer (MDA-MB-231) cell lines with an IC50 = 123.6 ± 0.8 μg/mL. However, the EOs were also treated with the human breast epithelial (MCF-10A) cell line, and from the results, it has been concluded that these oils did not produce much harm to the normal cell lines. Hence, the present research proved that the EOs of B. hirtum might be used to cure diabetes mellitus and human breast cancer. Moreover, further studies are considered to be necessary to isolate the responsible bioactive constituents to devise drugs for the observed activities.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

First Report on Comparative Essential Oil Profile of Stem and Leaves of Blepharispermum hirtum Oliver and Their Antidiabetic and Anticancer Effects

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Furthermore, β-caryophyllene ( 135 ) was the major compound detected in F. pulverulenta . The second major compounds were cadinene ( 134 ), allo-aromadendrene ( 136 ), copaene ( 128 ) and ledol ( 121 ) [ 18 ].…”

Section: Phytochemical Profile Of Frankenia Plantsmentioning

confidence: 99%

“…Therefore, alkanes are quite common in Frankenia species ( Table 8 ). Overall, 15 alkane chemicals ( 145 – 158 ) were reported in both F. laevis and F. pulverulenta [ 18 , 43 ].…”

Section: Phytochemical Profile Of Frankenia Plantsmentioning

confidence: 99%

Phytochemical Profiles and Biological Activities of Frankenia Species: A Review

Khaled,

Ouache,

Pale

et al. 2024

Molecules

View full text Add to dashboard Cite

The relatively small Frankeniaceae family is represented by halophyte plants, growing in arid and semi-arid climates in saline, alkaline or calcareous soils. Due to their living conditions, they usually produce a large diversity of compounds, which often exhibit bioactivities. Some species of this genus have long been used as traditional herbal medicines to treat dysentery, diarrhea, gonorrhea, vaginal leucorrhea, respiratory diseases and wounds. To date, several studies on either phytochemical or pharmacological aspects, or both, have revealed that this genus is a rich source of diverse and novel bioactive chemicals, including phenolics, flavonoids, alkaloids and fatty acids. This review describes all the reported chemical profiles of Frankenia species, as well as the corresponding biological properties, when available. The aim of this review is to show the potential of these plants for various applications, especially therapeutic ones.

show abstract

“…Medicinal plants are the prime source of alternative therapy for diabetes mellitus (DM) and numerous other human health complications [ 1 ]. Essential oils (EOs) produced from plants have multiple pharmacological and pharmaceutical properties including microbial resistance [ 1 , 2 , 3 ], scavenging free radicals [ 2 , 3 ], curing inflammation [ 4 , 5 , 6 ], α-glucosidase inhibition [ 7 ], carbonic anhydrase-II inhibition [ 8 , 9 ], and relieving pain [ 10 ]. In recent eras, the EOs obtained from medicinal herbs have gained attention due to their diverse biomedical applications including antidiabetic, antifungal, antibacterial, and pharmacological capabilities, as well as effective natural remedies [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

GC-MS Profiling and Biomedical Applications of Essential Oil of Euphorbia larica Boiss.: A New Report

et al. 2023

Self Cite

View full text Add to dashboard Cite

The present study explored Euphorbia larica essential oil (ELEO) constituents for the first time, obtained via hydro-distillation by means of Gas Chromatography-Mass Spectrometry (GC-MS) profiling. The essential oil was screened in vitro against breast cancer cells, normal cell lines, α-glucosidase, carbonic anhydrase-II (CA-II), free radical scavenging and in vivo analgesic and anti-inflammatory capabilities. The GC-MS screening revealed that the ELEO comprises sixty compounds (95.25%) with the dominant constituents being camphene (16.41%), thunbergol (15.33%), limonene (4.29%), eremophilene (3.77%), and β-eudesmol (3.51%). A promising antidiabetic capacity was noticed with an IC50 of 9.63 ± 0.22 μg/mL by the ELEO as equated to acarbose with an IC50 = 377.71 ± 1.34 μg/mL, while a 162.82 ± 1.24 μg/mL inhibition was observed against CA-II. Regarding breast cancer, the ELEO offered considerable cytotoxic capabilities against the triple-negative breast cancer (MDA-MB-231) cell lines, having an IC50 = 183.8 ± 1.6 μg/mL. Furthermore, the ELEO was also tested with the human breast epithelial (MCF-10A) cell line, and the findings also presumed that the ELEO did not produce any damage to the tested normal cell lines. The ELEO was effective against the Gram-positive bacteria and offered a 19.8 ± 0.02 mm zone of inhibition (ZOI) against B. atrophaeus. At the same time, the maximum resistance with 18.03 ± 0.01 mm ZOI against the fungal strain Aspergillus parasiticus was observed among the tested fungal strains. An appreciable free radical significance was observed via the DPPH assay with an IC50 = 133.53 ± 0.19 µg/mL as equated to the ABTS assay having an IC50 = 154.93 ± 0.17 µg/mL. The ELEO also offered a substantial analgesic capacity and produced 58.33% inhibition in comparison with aspirin, a 68.47% decrease in writhes, and an anti-inflammatory capability of 65.54% inhibition, as equated to the standard diclofenac sodium having 73.64% inhibition. Hence, it was concluded that the ELEO might be a natural source for the treatment of diabetes mellitus, breast cancer, analgesic, inflammatory, and antimicrobial-related diseases. Moreover, additional phytochemical and pharmacological studies are needed to isolate responsible chemical ingredients to formulate new drugs for the examined activities.

show abstract

Chemical Composition and Biological Activities of Essential Oil from Aerial Parts of Frankenia pulverulenta L. and Boerhavia elegans Choisy from Northern Oman

Cited by 8 publications

References 39 publications

First Report on Comparative Essential Oil Profile of Stem and Leaves of Blepharispermum hirtum Oliver and Their Antidiabetic and Anticancer Effects

First Report on Comparative Essential Oil Profile of Stem and Leaves of Blepharispermum hirtum Oliver and Their Antidiabetic and Anticancer Effects

Phytochemical Profiles and Biological Activities of Frankenia Species: A Review

GC-MS Profiling and Biomedical Applications of Essential Oil of Euphorbia larica Boiss.: A New Report

Contact Info

Product

Resources

About