Chemical composition and biological activity of Nepeta cilicica

İşcan, Gökalp; Göğer, Fatih; Demirci, Betül; Köse, Yavuz Bülent

doi:10.3329/bjp.v12i2.32010

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…In addition, the concentration of the different components in the methanol and water extracts might be different, and this was not specified in our data. In accordance with our results, the presence of flavones and hydroxycinnamic acid in the members of the Nepeta genus was reported in earlier studies [23][24][25][26][27].…”

Section: Resultssupporting

confidence: 94%

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Zengin

Mahomoodally

Jekő

et al. 2021

Plants

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Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.

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Section: Resultssupporting

confidence: 94%

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Zengin

Mahomoodally

Jekő

et al. 2021

Plants

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“…e DCM: methanol extract and compound B1 from T. welwitschii inhibited the production of eDNA and may be one of the mechanisms of disrupting biofilm formation by P. aeruginosa. us, phytochemicals from T. welwitschii may serve as antibiofilm and Anti-inflammatory and antihyperglycemic activities [40,41] Malonyl-monocinnamoylquinic acid Antibacterial and antifungal activities [42]…”

Section: Discussionmentioning

confidence: 99%

Antibiofilm Activity of Extract and a Compound Isolated from Triumfetta welwitschii against Pseudomonas aeruginosa

Mombeshora

Fru

Mukanganyama

2021

Biochemistry Research International

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Triumfetta welwitschii has been used as a traditional medicine in Africa. It is documented as a rich source of phytochemicals with antibacterial activities. To further explore the antibacterial potential of these phytochemical components, the phytochemical profile of the dichloromethane: methanol leaf extract from T. welwitschii was investigated using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Compounds were isolated from the extract using column chromatography and thin-layer chromatography. Compound B1 was isolated from the fraction eluted by 90 hexane:10 ethyl acetate using column chromatography. The antibacterial activity of B1 against Pseudomonas aeruginosa was evaluated in vitro using the broth microdilution method and the iodonitrotetrazolium (INT) colorimetric assay. The antibiofilm activities of the extract and B1 against P. aeruginosa were determined by quantifying the biofilms using crystal violet. The effect of the extract and B1 on capsular polysaccharide and extracellular DNA content of biofilm formed by P. aeruginosa was determined using phenol-sulphuric acid and propidium iodide, respectively. A total of 28 peaks were detected and identified using UPLC-MS/MS. The three most abundant phytochemicals identified were catechin, umbelliferone, and a luteolin derivative. B1 showed antibacterial activity against P. aeruginosa with a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) value of 25 μg/ml. Only 38% and 6% of the biofilms were formed in the presence of the extract and B1, respectively. The extract and B1 reduced the capsular polysaccharide content in biofilms formed in P. aeruginosa by 40% and 65%, respectively. The extract and B1 significantly reduced the extracellular DNA content of biofilms by 29% and 72%, respectively. The results of this study provide evidence of the antibacterial and antibiofilm activities of B1 and leaf extracts from T. welwitschii. Future work should identify the chemical structure of B1 using nuclear magnetic resonance and mass spectrometry.

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“…But the methanol extract showed lower inhibitory effect. İşcan et al [18] demonstrated that methanol extract of N. cilicica exhibited potent inhibition against S. aureus and C. tropicalis (47 µg/mL MIC). The ethanolic extract of N. trachonitica has demonstrated a strong antibacterial effect against E. coli (inhibition zone: 12.0 ± 1.24).…”

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confidence: 99%

An Endemic Species Nepeta phyllochlamys P. H. Davis: Composition of Essential Oil and Antimicrobial Activity of Extracts

Gülcan,

Köse,

Işcan

et al. 2024

C. R. Acad. Bulg. Sci.

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This study investigates the composition of essential oil and biological activities of Nepeta phyllochlamys P. H. Davis, a local endemic species from the Lamiaceae family. Samples of N. phyllochlamys were collected from three populations, and essential oil components were compared among these populations. The main components identified in samples from three localities included caryophyllene oxide, δ-pinene, linalool, T-cadinol, α-pinene, and 14-nor-kadin-5-en-4-one (isomer A). Remarkably, the chemical content of the plant exhibited variations based on geographical regions. Although the plant showed limited antibacterial and anticandidal activities in tests, this research holds significant importance due to several factors. N. phyllochlamys is a local endemic species and part of the widely used Nepeta genus in traditional practices. Moreover, there is a scarcity of studies conducted on N. phyllochlamys, and to the best of our knowledge, no previous research has explored its phytochemical profile and antimicrobial properties. This article contributes valuable insights into the antimicrobial effects of N. phyllochlamys, shedding light on its chemical composition through the application of the GC-FID and GC-MS method.

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Chemical composition and biological activity of Nepeta cilicica

Cited by 6 publications

References 9 publications

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Antibiofilm Activity of Extract and a Compound Isolated from Triumfetta welwitschii against Pseudomonas aeruginosa

An Endemic Species Nepeta phyllochlamys P. H. Davis: Composition of Essential Oil and Antimicrobial Activity of Extracts

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