Chemical Composition and Biological Activity of<i>Lavandula pubescens</i>Essential Oil from Yemen

Al-Badani, Rowaida N.; Silva, Joyce Kelly R. da; Mansi, Iman; Muharam, Bushra A.; Setzer, William N.; Ali, Nasser A. Awadh

doi:10.1080/0972060x.2017.1322538

Cited by 14 publications

(17 citation statements)

References 23 publications

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“…In the present study, we demonstrated for the first time that nanoparticles of TTO were able to prevent the upregulation of seric XO activity, similar to previous studies with essential oils, such as Boswellia dalzielii (Kohoude et al., ), Lavandula pubescens (Al‐Badani et al., ) and Salvia nemorosa (Bahadori et al., ). Although there are no prior data regarding the effect of TTO on XO activity, an in vitro study demonstrated that several terpenoids, including α‐terpinene (third principal compound of TTO), presented an inhibitory influence on XO activity with an IC 50 of 68.45 μg/ml (Umamaheswari et al., ).…”

Section: Discussionsupporting

confidence: 90%

Involvement of xanthine oxidase inhibition with the antioxidant property of nanoencapsulated Melaleuca alternifolia essential oil in fish experimentally infected with Pseudomonas aeruginosa

Baldissera

Souza

Doleski

et al. 2018

Journal of Fish Diseases

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Nanoencapsulated Melaleuca alternifolia essential oil (tea tree oil, TTO) is a natural alternative treatment, with 100% therapeutic efficacy in fish experimentally infected with Pseudomonas aeruginosa, and has also potent protective effects linked with antioxidant properties. However, the pathways responsible for the antioxidant capacity remain unknown. Thus, this study evaluated whether the inhibition of seric xanthine oxidase (XO) activity can be considered a pathway involved in the antioxidant capacity of nanoencapsulated TTO in fish experimentally infected with P. aeruginosa. Seric samples from fish infected with P. aeruginosa showed increased XO activity, as well as increased uric acid and reactive oxygen species (ROS) levels. In contrast, the prophylactic treatment with nanoencapsulated TTO prevented these infection-induced alterations. Based on the evidence obtained, the upregulation of seric XO activity induced pro-oxidative effects in the serum of fish experimentally infected with P. aeruginosa, due to excessive formation of uric acid, which stimulates the release of ROS. This treatment was able to prevent the upregulated seric XO activity and, consequently, the excessive formation of uric acid and ROS. In summary, inhibition of seric XO activity can be considered a pathway involved in the antioxidant capacity of nanoencapsulated TTO in fish experimentally infected with P. aeruginosa.

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Section: Discussionsupporting

confidence: 90%

Involvement of xanthine oxidase inhibition with the antioxidant property of nanoencapsulated Melaleuca alternifolia essential oil in fish experimentally infected with Pseudomonas aeruginosa

Baldissera

Souza

Doleski

et al. 2018

Journal of Fish Diseases

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“…e oxygenated monoterpenes were the dominant (73.26%) chemical group within the constituents, followed by sesquiterpene hydrocarbons (13.84%), monoterpene hydrocarbons (11.79%), and oxygenated sesquiterpenes (1.11%). e EO chemical profile in this study is qualitatively comparable to that formerly reported from Yemen where the EO has shown to be carvacrol chemotype (60.9-77.5%) [6,31].…”

Section: Gc-ms Analysissupporting

confidence: 88%

“…ere are no reports on the EO composition of L. pubescens growing wild in Palestine and only a few such reports are available worldwide [6,8,13,31]. Hydrodistillation of the L. pubescens leaves yielded 1.9 mL per 250 g fresh plant material.…”

Section: Gc-ms Analysismentioning

confidence: 99%

“…L. pubescens is common in the Dead Sea Valley, Jerusalem, and Hebron Desert and very rare in the Lower Jordan Valley and L. coronopifolia is common only in the Dead Sea Valley and only rare in Jerusalem and Hebron Desert, whereas L. stoechas is rare in Gaza Strip. Many pharmacological properties have been reported for lavender EOs, including local anesthetic, sedative, analgesic, anticonvulsant, antispasmodic [3,4], cholinesterase inhibitory [5], antioxidant [6,7], antibacterial, and antifungal effects and inhibition of microbial resistance [6,8], and they are used for the treatment of inflammation and many neurological disturbances [9]. e oil has also been utilized for relieving anxiety and associated sleep disorders [10], depression, and headache [11].…”

Section: Introductionmentioning

confidence: 99%

“…e EO of L. pubescens has been reported to exhibit a strong wide-ranging in vitro antibacterial activity against Gram-positive and Gram-negative bacteria including Salmonella enterica, Staphylococcus aureus, Micrococcus luteus, Enterococcus faecalis, and Escherichia coli [6,13,15] and hepatoprotective [16], cytotoxic, and xanthine-oxidase inhibitory activities [6,8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti‐Alzheimer’s Disease Agents

Ali‐Shtayeh¹,

Abu-Zaitoun²,

Dudai

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Lavandula pubescens Decne (LP) is one of the three Lavandula species growing wildly in the Dead Sea Valley, Palestine. The products derived from the plant, including the essential oil (EO), have been used in Traditional Arabic Palestinian Herbal Medicine (TAPHM) for centuries as therapeutic agents. The EO is traditionally believed to have sedative, anti-inflammatory, antiseptic, antidepressive, antiamnesia, and antiobesity properties. This study was therefore aimed to assess the in vitro bioactivities associated with the LP EO. The EO was separated by hydrodistillation from the aerial parts of LP plants and analyzed for its antioxidant, antimicrobial, anticholinesterase, and antilipase activities. GC-MS was used for phytochemical analysis. The chemical analysis of the EO composition revealed 25 constituents, of which carvacrol (65.27%) was the most abundant. EO exhibited strong antioxidant (IC50 0.16–0.18 μL/mL), antiacetylcholinesterase (IC50 0.9 μL/mL), antibutyrylcholinesterase (IC50 6.82 μL/mL), and antilipase (IC50 1.08 μL/mL) effects. The EO also demonstrated high antibacterial activity with the highest susceptibility observed for Staphylococcus aureus with 95.7% inhibition. The EO was shown to exhibit strong inhibitory activity against Candida albicans (MIC 0.47 μL/mL). The EO was also shown to possess strong antidermatophyte activity against Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum (EC50 0.05–0.06 μL/mL). The high antioxidant, enzyme inhibitory, and antimicrobial potentials of the EO can, therefore, be correlated with its high content of monoterpenes, especially carvacrol, as shown by its comparable bioactivities indicators results. This study provided new insights into the composition and bioactivities of LP EO. Our finding revealed evidence that LP EO makes a valuable natural source of bioactive molecules showing substantial potential as antioxidant, neuroprotective, antihyperlipidemic, and antimicrobial agents. This study demonstrates, for the first time, that LP EO might be useful for further investigation aiming at integrative CAM and clinical applications in the management of dermatophytosis, Alzheimer’s disease, and obesity.

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Advances in biological activities of essential oils

Mutlu-Ingök

Devecioglu

Dikmetaş

et al. 2022

Studies in Natural Products Chemistry

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Chemical Composition and Biological Activity ofLavandula pubescensEssential Oil from Yemen

Cited by 14 publications

References 23 publications

Involvement of xanthine oxidase inhibition with the antioxidant property of nanoencapsulated Melaleuca alternifolia essential oil in fish experimentally infected with Pseudomonas aeruginosa

Involvement of xanthine oxidase inhibition with the antioxidant property of nanoencapsulated Melaleuca alternifolia essential oil in fish experimentally infected with Pseudomonas aeruginosa

Downy Lavender Oil: A Promising Source of Antimicrobial, Antiobesity, and Anti‐Alzheimer’s Disease Agents

Advances in biological activities of essential oils

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