Chemical composition and biological activity of triterpenes and steroids of chaga mushroom

Nikitina, S.A.; Habibrakhmanova, V. R.; Сысоева, М А

doi:10.1134/s1990750816010108

Cited by 10 publications

(10 citation statements)

References 33 publications

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“…Currently, approximately 40 triterpene compounds of the lanostane series have been isolated from I. obliquus , as well as trace amounts of pentacyclic triterpenes such as betulin, lupeol, and lupenon (Gao, Xu, Lu, & Xu, ). Furthermore, steroids, mainly ergosterol and other typically plant‐derived steroidal compounds such as sitosterol, and stigmasterol have been identified, whereas the ergosterol content of I. obliquus was found to be lower when compared with the triterpene content (Nikitina, Khabibrakhmanova, & Sysoeva, ). The β‐ D ‐glucose polysaccharide (β‐glucan) content of I. obliquus is also a predominant bioactive compound that has attracted much interest owing to its beneficial properties on health as a prebiotic, and hypoglycemic agent (Ham et al, ).…”

Section: Chemical Analysis Of I Obliquusmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties. Chemical analysis of this mushroom has allowed the identification of various constituents such as melanins, phenolic compounds, and lanostane-type triterpenoids. A plethora of findings have highlighted the potential molecular mechanisms of actions of this mushroom such as its ability to scavenge reactive oxygen species, inhibit the growth of tumors, decrease inflammation and insulin resistance in type 2 diabetes, and stimulate the immune system. This review summarizes the relevant findings with reference to the therapeutic potential of this mushroom in countering the progression of cancers, diabetes mellitus, and antiviral activities, while highlighting its possible molecular mechanisms of action. The possible role of this mushroom as a therapeutic agent in addressing the pathogenesis of diabetes and cancer has also been suggested.

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Section: Chemical Analysis Of I Obliquusmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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“…The isolation and identification methods of these compounds are also briefly given in Table 2. Moreover, the review of Nikitina et al (2016), which summarized the original Russian articles, may provide different structural information about chaga terpenoids from those given in this contribution that is built upon using the English source. Lanostane-type terpenoids are well known for their potential in cancer treatment (Duru and Çayan, 2015).…”

Section: Terpenoidsmentioning

confidence: 99%

Bioactive compounds and bioactive properties of chaga ( Inonotus obliquus) mushroom: a review

Peng¹,

Shahidi²

2020

Journal of Food Bioactives

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Chaga (Inonotus obliquus) is an edible herbal mushroom extensively distributed in the temperate to frigid regions of the Northern hemisphere, especially the Baltic and Siberian areas. Chaga parasites itself on the trunk of various angiosperms, especially birch tree, for decades and grows to be a shapeless black mass. The medicinal/nutraceutical use of chaga mushroom has been recorded in different ancient cultures of Ainu, Khanty, First Nations, and other Indigenous populations. To date, due to its prevalent use as folk medicine/functional food, a plethora of studies on bioactive compounds and corresponding compositional analysis has been conducted in the past 20 years. In this contribution, various nutraceutical and pharmaceutical potential, including antioxidant, anti-inflammatory, anti-tumor, immunomodulatory, antimutagenic activity, anti-virus, analgesic, antibacterial, antifungal, anti-hyperglycemic, and anti-hyperuricemia activities/effects, as well as main bioactive compounds including phenolics, terpenoids, polysaccharides, fatty acids, and alkaloids of chaga mushroom have been thoroughly reviewed, and tabulated using a total 171 original articles. However, only key bioactivities and bioactives are selectively discussed. Besides, the up-to-date toxicity concerns and risk assessment about the misuse of chaga, which limit its acceptance and use as medicinal/nutraceutical products, have also been clarified.

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“…Inonotus obliquus can be even one of the potential candidates against the SARS-CoV-2 virus, but also several other antiviral effects of the conks have been shown in vitro and in vivo [ 11 ]. The triterpene and steroid compounds of these conks have demonstrated hepatoprotective, hypoglycemic, antifungal, antioxidant, and anti-inflammatory properties; in addition, they can regulate cholesterol biosynthesis [ 12 ]. In summary, I. obliquus is characterized as a promising natural material of biologically active substances against cancer and for immunotherapy [ 9 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analyses of Bioactive Compounds in Inonotus obliquus Conks Growing on Alnus and Betula

et al. 2022

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Inonotus obliquus grows in the Northern Hemisphere on some living broadleaved tree species as a pathogen, causing stem rot. In Estonia, the fungus is well known in the Betula species but can also be found on Alnus. Sterile conks of I. obliquus contain different bioactive compounds, but the quantitative and comparative research of these compounds in conks on different host species is limited. In the current work, I. obliquus was isolated and, evidently, determined from Alnus incana (L.) Moench., Alnus glutinosa (L.) Gaertn., and Betula pendula Roth, and the content of bioactive compounds in conks on these hosts were analysed. All the analysed conks sampled from A. incana and B. pendula contained betulin that varied from 111 to 159 µg/g. A significantly (p < 0.05) higher betulinic acid content was found in conks sampled from A. incana when compared with B. pendula: 474–635 and 20–132 µg/g, respectively. However, the conks from Betula were richer in total polyphenols, flavonols, and glucans. The content of inotodiol was quite similar in the conks from A. incana (7455–8961 µg/g) and B. pendula (7881–9057 µg/g). Also, no significant differences in the lanosterol content were found between the samples from these two tree species. To the best of our knowledge, this study is the first investigation of the chemical composition of I. obliquus parasitizing on Alnus. The results demonstrate that the bioactive compounds are promising in conks of I. obliquus growing not only on Betula but also on the Alnus species. It supports the opportunity to cultivate I. obliquus, also on the Alnus species, thus increasing the economic value of growing this tree species in forestry.

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Chemical composition and biological activity of triterpenes and steroids of chaga mushroom

Cited by 10 publications

References 33 publications

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Bioactive compounds and bioactive properties of chaga ( Inonotus obliquus) mushroom: a review

Comparative Analyses of Bioactive Compounds in Inonotus obliquus Conks Growing on Alnus and Betula

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