Chemical composition and biological activity of Gaultheria procumbens L. essential oil

Nikolić, Miloš; Marković, Tatjana; Mojović, Miloš; Pejin, Boris; Savić, Aleksandar; Perić, Tamara; Marković, Dejan; Stević, Tatjana; Sokóvić, Marina

doi:10.1016/j.indcrop.2013.06.002

Cited by 83 publications

(66 citation statements)

References 23 publications

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“…Hein [35] discussed the appropriate assessment methods and the approach to the scale of analysis of economic value for pollination at different scales (local, national, and global). Pollination is essential for many crops, even for plants that produce particular substances such as essential oils, and the role of honey bees remains fundamental [36,37]. Highly variable depending on the crop and the market conditions at local scale, pollination services range from 1% to 16% of the market value of agricultural production at the national scale.…”

Section: Introductionmentioning

confidence: 99%

Total Brood Removal and Other Biotechniques for the Sustainable Control of Varroa Mites in Honey Bee Colonies: Economic Impact in Beekeeping Farm Case Studies in Northwestern Italy

Mancuso

Croce²,

Vercelli

2020

Sustainability

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Honey bee colonies are affected by many threats, and the Varroa mite represents one of the most important causes of honey bee disease. The control of the Varroa population is managed by different methods, and in recent years, biotechnical practices are considered preferable to chemical approaches in order to safeguard honey bee health and avoid residues in bee products as well as the appearance of acaricide resistance. However, little is known about the economic performance of beekeeping exploitations in relation to the methods used for tackling Varroa. This study aims to investigate the economic impact of total brood removal (TBR) as a biotechnique to keep Varroa mites under control, and compare this to other common biotechniques and chemical Varroa control in numerous Italian beekeeping case studies. A pool of economic and technical indexes was proposed. The proposed index pool can be included in the development of an expert system (such as a decision support system) able to address the optimal management of this very complex activity, which requires natural resources, land protection, capital and high technical skills. The result showed that the adoption of the TBR biotechnique vs. other biotechniques led to an increase in terms of total revenue (increase values ranging from 11% to 28%) even though more labor is needed (increase values ranging from 43 to 83 min/hive) and a loss of honey production could be recorded in some cases. Additionally, the total expenses, represented mainly by supplemental nutrition and treatments with oxalic acid, affected the economic results of the biotechnical practices. The use of biotechniques vs. chemical control resulted in decreased treatment costs and increased feeding costs. The advantages resulting from not using synthetic acaricides (which are dangerous for honey bee and human health as well as the environment) as well as the advantages linked to the production of new nuclei (which are involved in the maintenance of bee stock and counteract the decline in honey bee population) and pollination ecosystem services could make beekeeping farms more resilient over time.

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Section: Introductionmentioning

confidence: 99%

Total Brood Removal and Other Biotechniques for the Sustainable Control of Varroa Mites in Honey Bee Colonies: Economic Impact in Beekeeping Farm Case Studies in Northwestern Italy

Mancuso

Croce²,

Vercelli

2020

Sustainability

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“…The most commonly used plant organs of G. procumbens are the leaves, traditionally valued as anti-inflammatory and analgesic agents as well as a source of wintergreen essential oil [ 1 ]. Methyl salicylate, constituting over 95% of the essential oil [ 2 ], and its glycosidic precursor—gaultherin [ 3 ]—are the main representatives of salicylates, so far considered as the primary active constituents of Gaultheria plants [ 4 , 5 , 6 ]. However, plant extracts are usually multicomponent and their activity is rarely due to one, single constituent.…”

Section: Introductionmentioning

confidence: 99%

“…That is also the case of Gaultheria plants, in which the presence of several lipophilic constituents, such as pentacyclic triterpenes and sterols, was discovered in selected taxons ( G. fragrantissima , G. nummularoides , G. paniculata , G. subcorymbosa , and G. yunnanensis ) by standard (isolation) techniques [ 1 , 9 , 10 , 11 , 12 , 13 ]. More selective methods (GC-MS) have so far been used only for identification of long-chain aliphatic alkanes C 15 –C 20 in leaf waxy layers of G. subcorymbosa and G. antipoda [ 14 ], and volatile fractions of various wintergreen species [ 1 , 2 ]. Some of the isolated non-volatile molecules, including pentacyclic triterpene acids, like oleanolic and ursolic acids, isomeric triterpene alcohols, like α- and β-amyrins, as well as phytosterols with the ubiquitous β-sitosterol, are well-documented anti-inflammatory agents, active in certain in vitro and in vivo models [ 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolite Profiling of Eastern Teaberry (Gaultheria procumbens L.) Lipophilic Leaf Extracts with Hyaluronidase and Lipoxygenase Inhibitory Activity

et al. 2017

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The phytochemical profile and anti-inflammatory activity of Gaultheria procumbens dry lipophilic leaf extracts were evaluated. Forty compounds were identified by GC-MS, representing 86.36% and 81.97% of the petroleum ether (PE) and chloroform (CHE) extracts, respectively, with ursolic acid (28.82%), oleanolic acid (10.11%), methyl benzoate (10.03%), and methyl salicylate (6.88%) dominating in CHE, and methyl benzoate (21.59%), docosane (18.86%), and octacosane (11.72%) prevailing in PE. Three components of CHE were fully identified after flash chromatography isolation and spectroscopic studies as (6S,9R)-vomifoliol (4.35%), 8-demethyl-latifolin (1.13%), and 8-demethylsideroxylin (2.25%). Hyaluronidase and lipoxygenase inhibitory activity was tested for CHE (IC50 = 282.15 ± 10.38 μg/mL and 899.97 ± 31.17 μg/mL, respectively), PE (IC50 = 401.82 ± 16.12 μg/mL and 738.49 ± 15.92 μg/mL), and nine of the main constituents versus heparin (IC50 = 366.24 ± 14.72 μg/mL) and indomethacin (IC50 = 92.60 ± 3.71 μg/mL) as positive controls. With the best activity/concentration relationships, ursolic and oleanolic acids were recommended as analytical markers for the extracts and plant material. Seasonal variation of both markers following foliar development was investigated by UHPLC-PDA. The highest levels of ursolic (5.36–5.87 mg/g DW of the leaves) and oleanolic (1.14–1.26 mg/g DW) acids were observed between August and October, indicating the optimal season for harvesting.

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“…as quercetin glycosides (3-O-glucoside, 3-O-galactoside, and 3-O-arabinoside), (+)-catechin, (-)-epicatechin, procyanidins A2 and B2, have been identified recently in the leaves of G. procumbens. [5]…”

Section: Research Articlementioning

confidence: 99%

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Singh¹

2017

IJGP

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Objective: The aim of this study was to evaluate chemical composition and biological activity of Gaultheria procumbens L. essential oil (EO). The components of EO were identified by GC-MS. Materials and Methods: Gas chromatography-mass spectrometry (GC-MS) analysis of isolated volatile oil and antimicrobial activity, antiarthritic, and antioxidant activity were determined by disc diffusion method, protein denaturation, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, respectively. Results: GC-MS analysis showed that methyl salicylate (61.14%) was the main volatile constituents of the isolated volatile oil. EO and dried alcoholic extracts of wintergreen plant inhibited the growth of all microorganisms tested, at the concentration of 1% mg/ml v/v. Significant anti-arthritic activity was observed compared to standard diclofenac sodium, and a dose-dependent DPPH-radical-scavenging activity with an EC50 value of 94.67% was also observed with the volatile oil. Conclusion: Overall, oil of wintergreen showed marked bioactivities and hence can be used in antiarthritic formulations used for local applications.

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Chemical composition and biological activity of Gaultheria procumbens L. essential oil

Cited by 83 publications

References 23 publications

Total Brood Removal and Other Biotechniques for the Sustainable Control of Varroa Mites in Honey Bee Colonies: Economic Impact in Beekeeping Farm Case Studies in Northwestern Italy

Total Brood Removal and Other Biotechniques for the Sustainable Control of Varroa Mites in Honey Bee Colonies: Economic Impact in Beekeeping Farm Case Studies in Northwestern Italy

Metabolite Profiling of Eastern Teaberry (Gaultheria procumbens L.) Lipophilic Leaf Extracts with Hyaluronidase and Lipoxygenase Inhibitory Activity

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