Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom

Soliev, Azamjon B.; Mirzaakhmedov, Sh. Ya.; Tashmukhamedov, M. S.; Камаев, Ф. Г.; Салихов, Ш. И.; Закирова, Н. И.; Abramov, AY; Usanova, I. V.; Сыров, В. Н.; Хушбактова, З. А.

doi:10.1007/s11094-008-0024-y

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…An overview of well-known bufadienolide-containing Bufo species was included in a comprehensive review. 2 Recent investigations indicated that bufadienolides are present in several diverse anurans [56][57][58][59][60] of the Bufonidae family, except Melanophryniscus species. 61,62 A hemisuberate of hellebrigenin 52 was isolated from the skin of Bufo bufo gargarizans, 63 and three unusual bufadienolide conjugates, 11a,19-dihydroxytelocinobufagin-3-(12-hydroxydodecanoic acid ester) 53, 11a,19-dihydroxytelocinobufagin-3-(14-hydroxy-7-tetradecenoic acid ester) 54 and 11a, 19-dihydroxytelocinobufagin-3-(14-hydroxytetradecanoic acid ester) 55, were separated from the ovaries of the cane toad, B. marinus.…”

Section: Bufonidaementioning

confidence: 99%

Bufadienolides and their antitumor activity

et al. 2011

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Section: Bufonidaementioning

confidence: 99%

Bufadienolides and their antitumor activity

et al. 2011

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“…Our early trials enabled us to isolate the sum of bufadienolides from Bufo viridis toad venom, that contained arenobufagin, gamabufotalin, telocinobufagin, marinobufagin, bufarenogin, and bufalin [19]. We further established that the sum of bufadienolides at 0.046-0.093 mg/kg concentration did not reveal embryotoxic and teratogenic effects in rats [20].…”

Section: Introductionmentioning

confidence: 81%

Effects of Bufadienolides from Bufo viridis Toad Venom on Blood Biochemical Compositions and Thromboelastographic Parameters

MIRAKHMETOVA,

VYPOVA,

ASROROV

et al. 2023

jrp

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Bufadienolides, cyclopentanophenantrene derivatives that possess similar structures to cardiac glycosides, have been established to reveal cytotoxicity. Their higher concentrations as anticancer means are expected to affect the normal function of the heart, liver, and kidney. In this work, we established the mass ratio of bufadienolides isolated from the venom of Bufo viridis. Arenobufagin, gamabufotalin, telocinobufagin, and marinobufagin were found as the major compounds in the sum. Their effects on biological parameters, used as indicators of the normal functioning of organs, were determined in rabbits. The blood samples, taken on the 10 th and 30 th days following the drug administration, showed these paramaters reaching the control levels for 30 days in all studied doses: 0.15, 0.45, and 0.6 mg/kg. The 0.15 and 0.6 mg/kg doses were established not to cause significant changes in the activities of alanine aminotransferase and aspartate aminotransferase, and the quantities of cholesterol and fasting blood sugar in blood samples. Significant changes were found in quantities of glucose (a reduction) and urea (an increase) on the 10 th day of the administration. But their levels reached the control level for the next 20 days. We observed significant differences in thromboelastographic parameters in mice on the 10 th day after the drug administration in a 0.15 mg/kg dose. In mice, LD50 levels of intravenous, subcutaneous, and oral administrations made 14.5, 110, and 215 mg/kg, respectively. These results enable the suggestion of optimum concentration that does not cause severe damage to the functions of organs.

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“…A 20 μg/mL dose of extract was found to enhance Ca 2+ in cardiomyocytes (Soliev et al, 2007). Previously, the ionotropic effect of the sum of bufadienolides was associated with the inhibition of Na + /K + -ATPase and partially with Ca 2+ -ATPase of the endoplasmic reticulum (Usanova et al, 2002).…”

Section: Effects Of Bufadienolides On Atpase Activitymentioning

confidence: 95%

“…The effects of the purified sum on the content of mitochondrial calcium were established, and based on it, we developed drug composition called Bakagin. A 20 μg/mL dose of extract was found to enhance Ca 2+ in cardiomyocytes (Soliev et al, 2007). Previously, the ionotropic effect of the sum of bufadienolides was associated with the inhibition of Na + /K + ‐ATPase and partially with Ca 2+ ‐ATPase of the endoplasmic reticulum (Usanova et al, 2002).…”

Section: Effects Of Bufadienolides On Atpase Activitymentioning

confidence: 99%

Toad venom bufadienolides and bufotoxins: An updated review

Asrorov,

Kayumov,

Mukhamedov

et al. 2023

Drug Development Research

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Bufadienolides, naturally found in toad venoms having steroid‐like structures, reveal antiproliferative effects at low doses. However, their application as anticancer drugs is strongly prevented by their Na+/K+‐ATPase binding activities. Although several kinds of research were dedicated to moderating their Na+/K+‐ATPase binding activity, still deeper fundamental knowledge is required to bring these findings into medical practice. In this work, we reviewed data related to anticancer activity of bufadienolides such as bufalin, arenobufagin, bufotalin, gamabufotalin, cinobufotalin, and cinobufagin and their derivatives. Bufotoxins, derivatives of bufadienolides containing polar molecules mainly belonging to argininyl residues, are reviewed as well. The established structures of bufotoxins have been compiled into a one‐page figure to review their structures. We also highlighted advances in the structure‐modification of the structure of compounds in this class. Drug delivery approaches to target these compounds to tumor cells were discussed in one section. The issues related to extraction, identification, and quantification are separated into another section.

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Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom

Cited by 10 publications

References 17 publications

Bufadienolides and their antitumor activity

Bufadienolides and their antitumor activity

Effects of Bufadienolides from Bufo viridis Toad Venom on Blood Biochemical Compositions and Thromboelastographic Parameters

Toad venom bufadienolides and bufotoxins: An updated review

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