Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil

Innocenti, Gabbriella; Dall’Acqua, Stefano; Scialino, Giuditta; Banfi, Elena; Sosa, Silvio; Gurung, Khilendra; Barbera, Mariagnese; Carrara, Maria

doi:10.3390/molecules15042326

Cited by 31 publications

(24 citation statements)

References 22 publications

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“…24 Usually, biological activity is assigned to major compounds. 25 The dominant group of compounds in B. tripartita root essential oil is the monoterpene hydrocarbons, with a-pinene as a main compound. Some studies have demonstrated good bacteriostatic and fungistatic properties of a-pinene, although some data show its low antimicrobial activity.…”

Section: Antimicrobial and Antifungal Activities Of The Essential Oilmentioning

confidence: 99%

Composition of the Essential Oil of Bidens tripartita L. Roots and Its Antibacterial and Antifungal Activities

Tomczykowa

Leszczyńska²,

Tryniszewska³

et al. 2011

Journal of Medicinal Food

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The chemical composition of the essential oil obtained from the roots of Bidens tripartita L. by hydrodistillation was investigated by gas chromatography-mass spectrometry. In total, 106 compounds were identified (97.1% of the total oil). The main components of the oil were α-pinene (15.0%), β-bisabolene (9.3%), p-cymene (6.0%), hexanal (5.7%), linalool (4.6%), p-cymene-9-ol (3.4%), β-elemene (2.6%), 2-pentylfuran (2.2%), and silphiperfol-6-ene (2.1%). The antibacterial and antifungal properties of the essential oil were evaluated against eight Gram-positive and 11 Gram-negative bacterial species and 10 fungal strains. The oil exhibited a strong antifungal activity.

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Section: Antimicrobial and Antifungal Activities Of The Essential Oilmentioning

confidence: 99%

Composition of the Essential Oil of Bidens tripartita L. Roots and Its Antibacterial and Antifungal Activities

Tomczykowa

Leszczyńska²,

Tryniszewska³

et al. 2011

Journal of Medicinal Food

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“…The essential oil of Rhododendron anthopogon was investigated by Innocenti et al (2010). The anti-microbial activity of R. anthopogon essential oil was evaluated by reference microdilution assays against a series of Gram-positive and Gram-negative reference strains.…”

Section: Figurementioning

confidence: 99%

“…Recently, there has been growing interests to find antimicrobial compounds from medicinal plant extracts as an alternative approach to discover new antimicrobial compounds (Ríos and Recio, 2005;Radji et al, 2013). Rhododendron species have been proved to possess medicinal and health promotion properties, including the ability to inhibit the growth of some types of pathogenic bacteria (Innocenti et al, 2010;Silici et al, 2010;Popescu and Kopp, 2013;Rezk et al, 2015;Wang et al, 2015;Li et al, 2016;Hakeem Said et al, 2017;Shrestha et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…These species are known to be a good source of polyphenolic plant secondary plant metabolites . The plant extracts belonging to the genus Rhododendron and isolated compounds demonstrated diverse biological activities including anti-inflammatory, analgesic, anti-microbial, antidiabetic, insecticidal and cytotoxic activity (Popescu and Kopp, 2013), as well as antibacterial activity (Innocenti et al, 2010;Silici et al, 2010;Popescu and Kopp, 2013;Rezk et al, 2015;Wang et al, 2015;Li et al, 2016;Hakeem Said et al, 2017;Shrestha et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial Activities of Ethanolic Extract Obtained from Rhododendron Myrtifolium Schott & Kotschy Leaves Against Clinically Isolated Bacterial Strains

Honcharenko¹,

Tkachenko²,

Prokopiv³

et al. 2019

Agrobiodiversity for Improving of Nutrition, Health and Life Quality

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The plants belonging to the genus Rhododendron L. and isolated compounds demonstrate diverse biological activities including anti-inflammatory, analgesic, anti-microbial, anti-diabetic, insecticidal and cytotoxic activity, as well as antibacterial activity. Our study was designed the effects of Rhododendron myrtifolium Schott & Kotschy leaf extract against bacterial strains were monitored in vitro by the disk diffusion method. The aim of this study was to assess possible antibacterial effects of an ethanolic extract derived from Rhododendron myrtifolium leaves against Citrobacter freundii, Enterobacter cloacae, Klebsiella pneumoniae, and Escherichia coli strain locally isolated from human biological fluids. Thus, the study contributes to on-going investigations on the bioactivity potential of plant species such as the Rhododendron. Leaves of Rhododendron myrtifolium were harvested on the side of the road between the Menchul valley and Rogneska valley (Kvasy village, Rakhiv district, Zakarpattia region, Ukraine). The results revealed that extract exerts antibacterial activity against Citrobacter freundii. However, the Enterobacter cloacae, Klebsiella pneumoniae, and Escherichia coli were resistant to R. myrtifolium leaf extract. Maximum in vitro inhibition was scored against Citrobacter freundii, followed by Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae, which presented inhibition zones of (12.1 ±0.9) mm, (9.1 ±0.5) mm, (7.5 ±0.6) mm, and (7.2 ±0.5) mm, respectively. In the case of the positive controls, 96% ethanol possesses a mild antibacterial effect, which presented inhibition zones of (6.5 ±0.7) mm. The results from the screening study performed by the disc diffusion method revealed that R. myrtifolium possesses a mild antibacterial activity against C. freundii. However, further investigation is needed to determine the bioavailability of the active compounds and to determine the dose and toxicity before it can be used as therapeutic agents.

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“…The use of herbs for the prevention and treatment of disease has been practiced for thousands of years in various countries, including China, Japan and Korea (1,2). Particularly in cancer treatment, polyherbal Chinese traditional medicine (TCM) formulas are widely used as an adjuvant therapy to surgery, chemotherapy and radiotherapy (3,4). Certain TCM herbs and formulas have previously been reported to target cancer by regulating immune function, inhibiting angiogenesis, inducing apoptosis and reversing the multi-drug resistance of tumor cells (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Jiedu Xiaozheng Yin decoction inhibits hepatoma cell proliferation by inducing apoptosis via the mitochondrial-mediated pathway

Cao

Chen

Lin

et al. 2015

Molecular Medicine Reports

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Jiedu Xiaozheng Yin decoction (JXY) is a type of Chinese traditional medicine, which has been used to treat various types of cancer. The present study explored the mechanisms underlying the anticancer activity of JXY. The effects of ethyl acetate extraction of JXY (EE-JXY) were evaluated on the HepG2 human hepatoma cell line in vitro and in vivo. Following treatment of the HepG2 cells with EE-JXY for 24 h, cell viability, apoptosis, mitochondrial membrane potential, caspase enzyme activity and the expression levels of apoptotic-associated proteins (Bcl-2 and Bax) were detected by MTT, flow cytometry, ELISA and western blotting respectively. In addition, HepG2 cells were subcutaneously transplanted into BALB/c nude mice, and the tumor bearing mice were treated with either EE-JXY (0.06 g/kg) or normal saline for 21 days. Tumor volume and weight were measured and recorded. The apoptotic index, and the expression levels of Bax and cytochrome c were determined with immunohistochemical staining. Treatment with EE-JXY inhibited the proliferation of HepG2 cells, and reduced cell viability in a dose-and time-dependent manner. Furthermore, EE-JXY induced HepG2 cell apoptosis, as demonstrated by a loss of plasma membrane asymmetry and externalization of phosphatidylserine, collapse of mitochondrial membrane potential, activation of caspase-9 and caspase-3, and an increased ratio of pro-apoptotic Bax to anti-apoptotic Bcl-2. Furthermore, EE-JXY inhibited tumor growth and increased the apoptotic index of tumors in tumor-bearing mice. In conclusion, the results of the present study suggest that JXY inhibits HepG2 cell proliferation through mitochondrion-mediated apoptosis, which may partially explain its anticancer activity.

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Chemical Composition and Biological Properties of Rhododendron anthopogon Essential Oil

Cited by 31 publications

References 22 publications

Composition of the Essential Oil of Bidens tripartita L. Roots and Its Antibacterial and Antifungal Activities

Composition of the Essential Oil of Bidens tripartita L. Roots and Its Antibacterial and Antifungal Activities

Antibacterial Activities of Ethanolic Extract Obtained from Rhododendron Myrtifolium Schott & Kotschy Leaves Against Clinically Isolated Bacterial Strains

Jiedu Xiaozheng Yin decoction inhibits hepatoma cell proliferation by inducing apoptosis via the mitochondrial-mediated pathway

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