Chemical composition and diuretic potential of the essential oil of <i>Cymbopogon densiflorus</i> (Steud.) Stapf. (Poaceae) in the mouse

Abstract

The present study focused on the diuretic activity of the essential oil (EO) of Cymbopogon densiflorus (Steud.) Stapf and the citral (majoritaire compound). The analysis of the chemical composition of this oil by gas chromatography coupled with mass spectrometry (GC/MS) made it possible to identify several molecules. It emerges from this study that only EO at 150 mg/kg causes significant diuretic activity (V.U.E = 168.39%) such as furosemide; the latter being modest (V.U.E = 143.62%) for citral at a dose of 75 mg/kg. In treated mice, removal of sodium was significant and potassium was spared compared to mice treated with distilled water. The diuretic effect of EO of C. densiflorus leaves demonstrated in the present study is a mode of action of this plant that justifies its use in traditional medicine against high blood pressure.

Contribution to the ethnobotanical inventory of medicinal plants used for the treatment of typhoid fever in Adamaoua region, Cameroon

“…Despite the permanent progress in pharmaceutical companies, resistance to different drug classes (Mfopa et al, 2017;Etou et al, 2019) has become an increasingly important problem (Madhulika et al, 2004, Lakshmi et al, 2006 especially in Subsahelian Africa where the income of ¾ of the total population do not allow them to afford and/or achieve antibiotherapy. In addition, although three vaccines are currently recommended by the WHO to prevent typhoid: an injectable vaccine on the purified Vi antigen (aka ViPS vaccine), the live attenuated oral Ty21a vaccine in the first instance and the latest generation typhoid conjugate vaccine (TCV), there is to date no vaccine against paratyphoid fever (Agwu et al, 2009).…”