Chemical composition and in vitro bioactivity of the volatile and fixed oils of Nigella sativa L. extracted by supercritical carbon dioxide

Piras, Alessandra; Rosa, Antonella; Marongiu, Bruno; Porcedda, Silvia; Falconieri, Danilo; Dessì, Ma; Özçelık, Berrın; Koca, Ufuk

doi:10.1016/j.indcrop.2013.02.013

Cited by 135 publications

(109 citation statements)

References 22 publications

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“…These results support previous studies which reported an effective antibacterial activity of N. sativa essential oil (22), thymoquinone (23) and carvacrol (24) against Gram-positive bacteria. DMSO and EtOH as diluents did not show any inhibitory effect on the growth of the strains.…”

Section: Discussionsupporting

confidence: 92%

Antibacterial and Resistance Modifying Activities of Nigella sativa Essential Oil and its Active Compounds Against Listeria monocytogenes

Mouwakeh

Telbisz

Spengler

et al. 2018

In Vivo

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Section: Discussionsupporting

confidence: 92%

Antibacterial and Resistance Modifying Activities of Nigella sativa Essential Oil and its Active Compounds Against Listeria monocytogenes

Mouwakeh

Telbisz

Spengler

et al. 2018

In Vivo

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“…Linoleic acid (63.85%), oleic acid (17.85%), and palmitic acid (11.21%) were the major components. This fatty acid profile was comparable to those reported on the literature [22].…”

Section: Fixed Oilsupporting

confidence: 90%

Antitumor and Antiangiogenic Effects of the Crude Oil of Nigella sativa L. in Tumor Tissues in BALB/c Mice

Bahramian

Bigdeli

Rasoulian

et al. 2016

Zahedan J Res Med Sci

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Background: Products of oxidation are known to trigger cancer through damaging cellular components and angiogenesis backs tumor growth and metastasis. Antioxidant enzymes like superoxide dismutase and catalase fight the stress posed by these products. Angiogenesis inhibition offers additional benefits toward tumor suppression. Nigella sativa L. is a plant traditionally used in Middle Eastern countries for its various benefits.

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“…However, our previous study and other studies have been highlighted on the higher antibacterial activity of N. sativa seed extract and oil extract on Gram positive bacteria. 20,[23][24][25][26][27] Furthermore, the antibacterial activity of N. sativa seed extract and its constituents against some strains of Streptococcus associated with dental caries has been reported as well. 14,28 Consistent to the results of previous studies, the present study demonstrated a strong growth inhibition and bactericidal activity of DLBS1355 o/w emulsion against S. mutans and S. sanguis, with a slightly higher activity on S. sanguis.…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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Our previous study highlighted the antimicrobial activity evaluation of Nigella sativa seed oil extract that was obtained from supercritical fluid extraction using carbon dioxide (SCFE-CO 2 ) on Gram positive pathogenic bacteria. The aim of this study was to formulate oil-in-water (o/w) emulsion of previous N. sativa seed oil extract and to investigate its antimicrobial activity against Streptococcus mutans and Streptococcus sanguis as the most common causative bacteria of dental caries. Oil-in-water emulsion containing 10% N. sativa seed oil extract (DLBS1355) exhibited good inhibition activity on both S. mutans and S. sanguis. Time-kill assay and biofilm inhibition assay were conducted using emulsion with 0.5% N. sativa seed oil extract content. The results showed bactericidal and biofilm inhibition activities on both tested bacteria. Antimicrobial activity of the emulsion was found higher on S. sanguis than S. mutans. Results of the present study showed that emulsification process did not significantly affect the antimicrobial activity of N. sativa seed oil extract and the formulated N. sativa oil-in-water emulsion could further be used as an antimicrobial agent against dental cariogenic bacteria.

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Chemical composition and in vitro bioactivity of the volatile and fixed oils of Nigella sativa L. extracted by supercritical carbon dioxide

Cited by 135 publications

References 22 publications

Antibacterial and Resistance Modifying Activities of Nigella sativa Essential Oil and its Active Compounds Against Listeria monocytogenes

Antibacterial and Resistance Modifying Activities of Nigella sativa Essential Oil and its Active Compounds Against Listeria monocytogenes

Antitumor and Antiangiogenic Effects of the Crude Oil of Nigella sativa L. in Tumor Tissues in BALB/c Mice

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