Chemical composition, antioxidant activity and hepatoprotective potential of Rourea induta Planch. (Connaraceae) against CCl4-induced liver injury in female rats

Abstract

RIEE exhibits antioxidant and hepatoprotective activities in vivo, which may be attributable to its flavonoids composition [hyperin (2), quercetin-3-O-β-xyloside (4), quercetin-3-O-α-arabinofuranoside (5), and quercetin (6)].

Hematological, antioxidant and protective performance of Usnea longissima on chemical induced hepatotoxicity in experimental animals

“…Oxidative stress resulting from an imbalance in the antioxidant defense system and production of reactive oxygen species (ROS) are including superoxide radicals, hydroxyl radicals, and hydrogen peroxide, arising from aerobic metabolism in free radicals interacting with endogenous macromolecules [30].…”

Moringa oleifera Enriched Diet Ammeliorates the Toxic Effects of Palm Wine and Local Gin (Ogogoro) on Some Biochemical Parameters in Albino Rats

“…ALT is a cytoplasmic enzyme found in very high concentration in the liver and an increase of this specific enzyme indicates hepatocellular damage, while AST is less specific than ALT as an indicator of liver function [30]. An increase in the enzyme activity indicates cellular leakage and loss of functional integrity of the hepatic cell membrane [31,32]. The elevated levels of these biochemical parameters are direct reflection of alterations in the hepatic structural integrity [33].…”

Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

“…Although different parameters were obtained from different studies, the underlying mechanisms mainly focus on reducing oxidative stress, decreasing inflammatory response, suppressing apoptosis, and blocking lipid peroxidation, resulting in normalizing serum and hepatic biomarkers and in improved histopathological conditions. Herbs like Polygonum multiflorum , Rosa laevigata Michx, Rourea induta Planch., and Cuscuta campestris Yunck have shown hepatoprotective effects in rodent models, even though the extracts were isolated from different parts of the plants or with different extracting solutions (Kalegari et al., ; Lee, Huang, Duh, & Wu, ; Peng et al., ; Zhang et al., ). Formulas of traditional medicines have been used based on the thought that some ingredients could work synergistically and avoid side effects.…”