Chemical Composition, In Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas inflata Benth

Abstract

The essential oil of Leucas inflata Balf.f. (Lamiaceae), collected in Yemen, was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. Forty-three components were recognized, representing 89.2% of the total oil. The L. inflata volatile oil was found to contain a high percentage of aliphatic acids (51.1%). Hexadecanoic acid (32.8%) and n-dodecanoic acid (7.8%) were identified as the major compounds. Oxygenated monoterpenes were distinguished as the second significant group of constituents (16.0%). Camphor (6.1%) and linalool (3.2%) were found to be the main components among the oxygenated monoterpenes. In addition, the volatile oil was assessed for its antimicrobial activity against four bacterial strains and one yeast species using broth micro-dilution assay for minimum inhibitory concentrations (MIC). In addition, antioxidant activity was measured utilizing the anti-radical activity of the sable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and β-Carotene-linoleic acid assays. The oil of L. inflata showed an excellent antibacterial activity against only the tested Gram-positive bacteria with a MIC-value of 0.81 mg/mL. Furthermore, the oil demonstrated, at a concentration of 1 mg/mL, a weak to moderate antiradical and antioxidant activity of 38% and 32%, respectively.

Evaluation of Possible Antioxidant, Anti-Hyperglycaemic, Anti-Alzheimer and Anti-Inflammatory Effects of Teucrium polium Aerial Parts (Lamiaceae)

“…Naturally occurring antioxidants of plant origin are highly popular for combatting oxidative stress and counteracting inflammation and its associated disorders, owing to their richness with bioactive secondary metabolites [ 6 , 7 , 8 , 9 ]. Furthermore, they have the potential to effectively inhibit oxidative stress that is associated with diseases such as diabetes and neurodegenerative disorders [ 10 ].…”

Chemical Composition, Antimicrobial Properties of Siparuna guianensis Essential Oil and a Molecular Docking and Dynamics Molecular Study of its Major Chemical Constituent

“…The plants that produce essential oils (EOs) have been an object of study for years, since their EOs present varied biological activities [ 14 ], such as cytotoxic, antimicrobial, antioxidant [ 15 ], anti-inflammatory, anti-proliferative [ 16 , 17 , 18 ], antibacterial, antifungal [ 19 , 20 , 21 , 22 , 23 , 24 ], antiviral [ 25 , 26 ], anticonvulsant [ 27 , 28 ], analgesic [ 29 ], and neuroprotective properties [ 30 ]. As a result, they are increasingly attracting the attention of many industry segments [ 31 ].…”

Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation

“…is a herbal medicine widely available in Southeast Asia for reducing inflammatory symptoms ( Ku et al, 2000 ). The essential oil isolated from LC has antimicrobial, free radical scavenging and antioxidant activities ( Mothana et al, 2017 ). These two herbs can be used alone or in combination with three other herbs, Euonymus laxiflorus Champ.…”