Chemical Composition of Leaf Essential Oil of <i>Piper umbellatum</i> and Aerial Part Essential Oil of <i>Piper guineense</i> From Côte d’Ivoire

Kambiré, Didjour Albert; Yapi, Thierry Acafou; Boti, Jean Brice; García, Gabriel Puyana; Tomi, Pierre; Bighelli, Ange; Tomi, Félix

doi:10.1177/1934578x19859124

Cited by 8 publications

(12 citation statements)

References 17 publications

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“…Several studies from P. umbellatum have shown the presence of alkaloids, flavonoids, sterols, and terpenes. Many of them are found in essential oil and other classes of secondary metabolites (Didjour et al 2019). These results suggest that knowledge on virtues of traditional medicine is shared across countries, continents and support our findings.…”

Section: Types Of Chemical Compoundssupporting

confidence: 89%

“…Extracts and pure compounds derived from various parts of P. umbellatum have shown several pharmacological activities, including anti-inflammatory, analgesic, antiatherogenic, cytotoxic, anti-platelet, anti-rheumatism, antimalarial, antifungal, antibacterial, anti-leishmanial, pain, oedema, and anti-trypanosomal activities (Agbor et al 2012;da Silva et al 2014;Didjour et al 2019). Several studies from P. umbellatum have shown the presence of alkaloids, flavonoids, sterols, and terpenes.…”

Section: Types Of Chemical Compoundsmentioning

confidence: 99%

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Ethnobotanical survey and phytochemical screening of anti-snakebite plants used in Bissok District of Gabon

Mengome¹,

Mewono²,

Mboma³

et al. 2021

Biodiversitas

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Abstract. Mengome, Mewono L, Mboma R, Engohang-Ndong J, Angone SA. 2021. Ethnobotanical survey and phytochemical screening of anti-snakebite plants used in Bissok District of Gabon. Biodiversitas 22: 3264-3275. Snakebites remain a major health issue in tropical and subtropical regions in the world. The limited access of antivenom sera in remote areas of many countries forces populations to rely on plant-based remedies to manage snakebite-induced injury. In this study, we conducted an ethnobotanical survey of medicinal plants used for the management of snakebites in the district of Bissok (Northern Gabon). After collecting and verifying the authenticity of the plants, we further performed their phytochemical analysis. The procedure used in this study involved a structured questionnaire and direct interviews of local populations. Overall, data collected on-site included local names, the part of the plant used, the preparation, and the route of administration. The presence of some phytochemical compounds was determined according to standard methods. Overall, a total of 29 species of plants belonging to 20 different families were reported to be used to treat snakebites. The plants used were herbs (44.80%), trees (24.10%), shrubs (20.70%), liana (10.30%), and rhizomes (6.90%). They were mainly used as poultice or crush, and to a lesser extent as decoction and maceration. Regarding the route of administration, interviewees reported mainly external use on the site of the bite. Concerning the chemical composition, we found that the antivenom plants were rich in chemical compounds known to have antivenom, antipyretic and antimicrobial properties, e.g. alkaloids, terpenoids, flavonoids, steroids, coumarins, phenols, tannins gallic Our results open avenues to develop venom enzyme inhibitory assays.

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Section: Types Of Chemical Compoundssupporting

confidence: 89%

Section: Types Of Chemical Compoundsmentioning

confidence: 99%

Ethnobotanical survey and phytochemical screening of anti-snakebite plants used in Bissok District of Gabon

Mengome¹,

Mewono²,

Mboma³

et al. 2021

Biodiversitas

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“…Leaves from I. dewevrei produced a sesquiterpene-rich essential oil with an original chemical composition, displaying various compounds that are reported for the first time. The previously reported chemical composition of leaf oil from this species was dominated by germacrene B, (5αH,10βMe)-6,12-oxido-elema-1,3,6,11(12)-tetraene, germacrene D, (Z)-β-ocimene, γ-elemene and (E)-β-caryophyllene [14]. Thus, qualitative and quantitative differences appeared between the compositions of the previous and the present study.…”

Section: Chemical Composition Of Leaf Essential Oil From I Dewevreicontrasting

confidence: 59%

“…Continuing the chemical characterization of essential oils of aromatic and medicinal plants from Côte d'Ivoire [10][11][12][13][14], we now report on the chemical composition of the leaf essential oil from I. dewevrei, along with isolation and structure elucidation of three new natural sesquiterpenes as well as description of NMR data of a fourth sesquiterpene.…”

Section: Introductionmentioning

confidence: 99%

New Natural Oxygenated Sesquiterpenes and Chemical Composition of Leaf Essential Oil from Ivoirian Isolona dewevrei (De Wild. & T. Durand) Engl. & Diels

et al. 2020

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This study aimed to investigate the chemical composition of the leaf essential oil from Ivoirian Isolona dewevrei. A combination of chromatographic and spectroscopic techniques (GC(RI), GC-MS and 13C-NMR) was used to analyze two oil samples (S1 and S2). Detailed analysis by repetitive column chromatography (CC) of essential oil sample S2 was performed, leading to the isolation of four compounds. Their structures were elucidated by QTOF-MS, 1D and 2D-NMR as (10βH)-1β,8β-oxido-cadin-4-ene (38), 4-methylene-(7αH)-germacra-1(10),5-dien-8β-ol (cis-germacrene D-8-ol) (52), 4-methylene-(7αH)-germacra-1(10),5-dien-8α-ol (trans-germacrene D-8-ol) (53) and cadina-1(10),4-dien-8β-ol (56). Compounds 38, 52 and 53 are new, whereas NMR data of 56 are reported for the first time. Lastly, 57 constituents accounting for 95.5% (S1) and 97.1% (S2) of the whole compositions were identified. Samples S1 and S2 were dominated by germacrene D (23.6 and 20.5%, respectively), followed by germacrene D-8-one (8.9 and 8.7%), (10βH)-1β,8β-oxido-cadin-4-ene (7.3 and 8.7), 4-methylene-(7αH)-germacra-1(10),5-dien-8β-ol (7.8 and 7.4%) and cadina-1(10),4-dien-8β-ol (7.6 and 7.2%). Leaves from I. dewevrei produced sesquiterpene-rich essential oil with an original chemical composition, involving various compounds reported for the first time among the main components. Integrated analysis by GC(RI), GC-MS and 13C-NMR appeared fruitful for the knowledge of such a complex essential oil.

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“…The studied leaf oil samples evidenced three chemical compositions dominated either by germacrene B, (5αH,10βMe)-6,12-oxido-elema-1,3,6,11(12)-tetraene, germacrene D, ( Z )-β-ocimene, γ-elemene and ( E )-β-caryophyllene, or by germacrene D, germacrene D-8-one, (10βH)-1β,8β-oxido-cadina-4-ene, (7βH)-germacrene D-8α-ol and cadina-1(10),4-dien-8β-ol, or by (10βH)-1β,8β-oxido-cadina-4-ene, ( E )-β-caryophyllene, germacrene D, cadina-1(10),4-dien-8β-ol and caryophyllene oxide. Therefore, continuing our study on the chemical characterization of essential oils from Côte d’Ivoire [ 17 , 18 , 19 , 20 , 21 ], the chemical variability of the leaf essential oil of I. dewevrei was evaluated by investigating a larger number of oil samples (47). The in vitro anti-inflammatory activity of this essential oil was tested too.…”

Section: Introductionmentioning

confidence: 99%

Chemical Variability and In Vitro Anti-Inflammatory Activity of Leaf Essential Oil from Ivorian Isolona dewevrei (De Wild. & T. Durand) Engl. & Diels

et al. 2021

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The chemical variability and the in vitro anti-inflammatory activity of the leaf essential oil from Ivorian Isolona dewevrei were investigated for the first time. Forty-seven oil samples were analyzed using a combination of CC, GC(RI), GC-MS and 13C-NMR, thus leading to the identification of 113 constituents (90.8–98.9%). As the main components varied drastically from sample to sample, the 47 oil compositions were submitted to hierarchical cluster and principal components analyses. Three distinct groups, each divided into two subgroups, were evidenced. Subgroup I−A was dominated by (Z)-β-ocimene, β-eudesmol, germacrene D and (E)-β-ocimene, while (10βH)-1β,8β-oxido-cadina-4-ene, santalenone, trans-α-bergamotene and trans-β-bergamotene were the main compounds of Subgroup I−B. The prevalent constituents of Subgroup II−A were germacrene B, (E)-β-caryophyllene, (5αH,10βMe)-6,12-oxido-elema-1,3,6,11(12)-tetraene and γ-elemene. Subgroup II−B displayed germacrene B, germacrene D and (Z)-β-ocimene as the majority compounds. Germacrene D was the most abundant constituent of Group III, followed in Subgroup III−A by (E)-β-caryophyllene, (10βH)-1β,8β-oxido-cadina-4-ene, germacrene D-8-one, and then in Subgroup III−B by (Z)-β-ocimene and (E)-β-ocimene. The observed qualitative and quantitative chemical variability was probably due to combined factors, mostly phenology and season, then harvest site to a lesser extent. The lipoxygenase inhibition by a leaf oil sample was also evaluated. The oil IC50 (0.020 ± 0.005 mg/mL) was slightly higher than the non-competitive lipoxygenase inhibitor NDGA IC50 (0.013 ± 0.003 mg/mL), suggesting a significant in vitro anti-inflammatory potential.

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Chemical Composition of Leaf Essential Oil of Piper umbellatum and Aerial Part Essential Oil of Piper guineense From Côte d’Ivoire

Cited by 8 publications

References 17 publications

Ethnobotanical survey and phytochemical screening of anti-snakebite plants used in Bissok District of Gabon

Ethnobotanical survey and phytochemical screening of anti-snakebite plants used in Bissok District of Gabon

New Natural Oxygenated Sesquiterpenes and Chemical Composition of Leaf Essential Oil from Ivoirian Isolona dewevrei (De Wild. & T. Durand) Engl. & Diels

Chemical Variability and In Vitro Anti-Inflammatory Activity of Leaf Essential Oil from Ivorian Isolona dewevrei (De Wild. & T. Durand) Engl. & Diels

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