Chemical Constituents from the Leaves and Stems of Schisandra lancifolia

Xiao, Wei‐Lie; Yang, Liu‐Meng; Zhang, Hai-Bo; Xue, Yongbo; Yang, Guangyu; Pu, Jian‐Xin; Wang, Ruirui; Zheng, Yong‐Tang; Sun, Han‐Dong

doi:10.1248/cpb.58.852

Cited by 13 publications

(4 citation statements)

References 30 publications

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“…The lignans from this family are commonly classified into five classes, i.e., dibenzocyclooctadiene, spirobenzofuranoid dibenzocyclooctadiene, 1,4-diarylbutane, 4-aryltetralin, and diaryltetrahydrofuran [1]. Recent pharmacological studies have revealed that these compounds accounted for anti-oxidant [2,3], anti-HIV [4,5], antihepatitis B virus [6], and anti-proliferative multiple bio-effects [7]. In addition, schisantherin A (2) has been reported to exhibit anti-inflammatory properties by down-regulating NF-kappaB and MAPK signaling pathways in lipopolysaccharide-treated RAW 264.7 cells [8].…”

Section: Introductionmentioning

confidence: 99%

Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity

Liu

Padula

et al. 2013

European Journal of Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity

Liu

Padula

et al. 2013

European Journal of Medicinal Chemistry

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“…sinensis (Sichuan, China) Aerial parts 294–297 HIV-1 294 + 295 EC 50 7.7 μM Li et al ( 2009b ) Schisandra propinqua (Hubei, China) Leaves and stems 298–306 HIV-1 IN DNA binding EC 50 > 25 μM Shang et al ( 2013a ) Schisandra rubriflora (Yunnan, China) Fruits 307 HIV-1 IIIB induced syncytium formationHIV-1IIIB inducted MT-4 cells lytic effects HIV-1 IIIB induced syncytium formation EC 50 30.0 μM HIV-1IIIB inducted MT-4 cells lytic effects EC 50 10.8 μM Xiao et al ( 2010a ) Schisandra chinensis (Heilongjiang, China) Leaves and stems 308–309 HIV-1 309 EC 50 66.1 μM Shi et al ( 2014 ) Kadsura longipedunculata (Sichuan, China) Leaves and stems 310–311 HIV-1 311 EC 50 35.9 μM Pu et al ( 2008a ) Schisandra lancifolia (Yunnan, China) 312–313 HIV-1 312 EC 50 212 μM, 313 EC 50 149 μM Xiao et al ( 2010b ) Peperomia heyneana (Piperaceae, Yunnan, China) Whole plants 314 HIV-1 EC 50 50 μM Zhang et al ( 2007 ) Saururus chinensis (Saururaceae, Guangxi, China) …”

Section: Arylnaphthalene-type Lignansmentioning

confidence: 99%

“…Balaphonin ( 406 ) was obtained from the leaves and stems of S. lancifolia (Yunnan, China). It showed anti-HIV-1 effects with an EC 50 value of 8.43 μM and a TI value of 4.3, respectively (Xiao et al 2010b ). …”

Section: Benzofuran Lignansmentioning

confidence: 99%

Plant-derived lignans as potential antiviral agents: a systematic review

Wang

et al. 2021

Phytochem Rev

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Medicinal plants are one of the most important sources of antiviral agents and lead compounds. Lignans are a large class of natural compounds comprising two phenyl propane units. Many of them have demonstrated biological activities, and some of them have even been developed as therapeutic drugs. In this review, 630 lignans, including those obtained from medicinal plants and their chemical derivatives, were systematically reviewed for their antiviral activity and mechanism of action. The compounds discussed herein were published in articles between 1998 and 2020. The articles were identified using both database searches (e.g., Web of Science, Pub Med and Scifinder) using key words such as: antiviral activity, antiviral effects, lignans, HBV, HCV, HIV, HPV, HSV, JEV, SARS-CoV, RSV and influenza A virus, and directed searches of scholarly publisher’s websites including ACS, Elsevier, Springer, Thieme, and Wiley. The compounds were classified on their structural characteristics as 1) arylnaphthalene lignans, 2) aryltetralin lignans, 3) dibenzylbutyrolactone lignans, 4) dibenzylbutane lignans, 5) tetrahydrofuranoid and tetrahydrofurofuranoid lignans, 6) benzofuran lignans, 7) neolignans, 8) dibenzocyclooctadiene lignans and homolignans, and 9) norlignans and other lignoids. Details on isolation and antiviral activities of the most active compounds within each class of lignan are discussed in detail, as are studies of synthetic lignans that provide structure–activity relationship information.

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“…A nortriterpenoid, 20‐hydroxymicrandilactone D ( 253 ; Figure 53) was isolated from Schisandra lancifolia . Compound 257 showed anti‐HIV‐1 activities with EC 50 value of 99.0 μg/ml 108 . Six nortriterpenoids, schirubridilactones A–F ( 254 – 259 ; Figure 54) were isolated from Schisandra rubriflora .…”

Section: Tetracyclic Triterpenoidmentioning

confidence: 99%

Recent advances in natural anti‐HIV triterpenoids and analogs

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

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The human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic is one of the world's most serious health challenges. Although combination antiretroviral therapy provides effective viral suppression, current medicines used against HIV cannot completely eradicate the infectious disease and often have associated toxicities and severe side effects in addition to causing drug resistance. Therefore, the continued development of new antiviral agents with diverse structures and novel mechanisms of action remains a vital need for the management of HIV/AIDS. Natural products are an important source of drug discovery, and certain triterpenes and their analogs have demonstrated potential as pharmaceutical precursors for the treatment of HIV. Over the past decade, natural triterpenoids and analogs have been extensively studied to find new anti-HIV drugs. This review discusses

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Chemical Constituents from the Leaves and Stems of Schisandra lancifolia

Cited by 13 publications

References 30 publications

Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity

Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity

Plant-derived lignans as potential antiviral agents: a systematic review

Recent advances in natural anti‐HIV triterpenoids and analogs

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