Chemical Exchange Saturation Transfer (CEST) MR Technique for Liver Imaging at 3.0 Tesla: an Evaluation of Different Offset Number and an After-Meal and Over-Night-Fast Comparison

Deng, Min; Chen, Shu Zhong; Yuan, Jing; Chan, Queenie; Zhou, Jinyuan; Wáng, Yì Xiáng J.

doi:10.1007/s11307-015-0887-8

Cited by 33 publications

(47 citation statements)

References 48 publications

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“…Additionally, to further improve this black blood T1ρ relaxometry sequence, additional techniques can be incorporated, including more robust measurement (22,(40)(41)(42)(43) and faster data sampling and reconstruction (44). Recently, the feasibility of CEST (chemical exchange saturation transfer) technique for liver imaging has been demonstrated (38,45). MR Elastography technique has also been further validated for assessing diffused liver diseases (46,47).…”

Section: Bdl Is a Well Established Model For Liver Fibrosis Researchmentioning

confidence: 99%

Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model

Koon¹,

Zhang²,

Chen

et al. 2016

Quant. Imaging Med. Surg.

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Background: To explore black blood T1rho (T1ρ) liver imaging and investigate the earliest stage when biliary duct ligation (BDL) induced liver fibrosis can be diagnosed.Methods: MR was performed at 3 Tesla. A T1ρ prepared 2D fast spin echo (FSE) sequence with acquisition of four spin lock times (TSLs: 1, 10, 30, and 50 msec) and spin-lock frequency of 500 Hz was applied.Inherent black blood effect of FSE and double inversion recovery (DIR) achieved blood signal suppression, and 3 axial sections per liver were obtained. Male Sprague-Dawley rats were scanned at baseline (n=32), and on day-3 (n=13), day-5 (n=11), day-7 (n=10), day-10 (n=4) respectively after BDL. Hematoxylin-eosin (HE) and picrosirius red staining liver histology was obtained at these time points.Results: The physiological liver parenchyma T1ρ was 38.38±1.53 msec (range, 36.05-41.53 msec). Liver T1ρ value elevated progressively after BDL. On day-10 after BDL all experimental animals can be separated from normal liver based on T1ρ measurement with lowest value being 42.82 msec. Day-7 and day-10 liver resembled METAVIR stage-F1/F2 fibrosis, and fibrous area counted for 0.22%±0.13% and 0.38%±0.44% of liver parenchyma area, respectively. Conclusions:This study provides the first proof-of-principle that T1ρ might diagnose early stage liver fibrosis.

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Section: Bdl Is a Well Established Model For Liver Fibrosis Researchmentioning

confidence: 99%

Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model

Koon¹,

Zhang²,

Chen

et al. 2016

Quant. Imaging Med. Surg.

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“…Very few studies have attempted glycoCEST in humans at 3T as motion of organs, and B 0 spatial inhomogeneity and temporal changes present a challenge to quantification. One study has demonstrated liver glycogen reduction after fasting . Another has shown that muscle glycogen can be assessed at 3T with proper frequency correction using the WASSR method .…”

Section: Discussionmentioning

confidence: 99%

“…One study has demonstrated liver glycogen reduction after fasting. 48 Another has shown that muscle glycogen can be assessed at 3T with proper frequency correction using the WASSR method. 8 The DvNav-based prospective frequency and first order shim measurement and correction presented here could improve accuracy of muscle glycogen CEST measurements.…”

Section: Discussionmentioning

confidence: 99%

Real‐time simultaneous shim and motion measurement and correction in glycoCEST MRI using double volumetric navigators (DvNavs)

Simegn

Kouwe

Robertson

et al. 2018

Magnetic Resonance in Med

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Purpose CEST MRI allows for indirect detection of molecules with exchangeable protons, measured as a reduction in water signal because of continuous transfer of saturated protons. CEST requires saturation pulses on the order of a second, as well as repeated acquisitions at different offset frequencies. The resulting extended scan time makes CEST susceptible to subject motion, which introduces field inhomogeneity, shifting offset frequencies and causing distortions in CEST spectra that resemble true CEST effects. This is a particular problem for molecules that resonate close to water, such as hydroxyl group in glycogen. To address this, a technique for real‐time measurement and correction of motion and field inhomogeneity is proposed. Methods A CEST sequence was modified to include double volumetric navigators (DvNavs) for real‐time simultaneous motion and shim correction. Phantom tests were conducted to investigate the effects of motion and shim changes on CEST quantification and to validate the accuracy of DvNav motion and shim estimates. To evaluate DvNav shim and motion correction in vivo, acquisitions including 5 experimental conditions were performed in the calf muscle of 2 volunteers. Results Phantom data show that DvNav‐CEST accurately estimates frequency and linear gradient changes because of motion and corrects resulting image distortions. In addition, DvNav‐CEST improves CEST quantification in vivo in the presence of motion. Conclusion The proposed technique allows for real‐time simultaneous motion and shim correction with no additional scanning time, enabling accurate CEST quantification even in the presence of motion and field inhomogeneity.

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“…114 On the other hand, the Cr level is low in the liver, and glycoCEST may be more useful, and is indeed being tried in humans. 196,197 However, glucose signals will overlap with those of glycogen and, when using MTR asym , NOE effects may also be mixed in. Thus, further editing will likely be needed to cleanly separate out these effects in the leg and the liver.…”

Section: Cest Studies Of Creatine (Crcest) and Glycogen (Glycocest)mentioning

confidence: 99%

Proton Chemical Exchange Saturation Transfer (CEST) MRS and MRI

Zijl

Sehgal

2016

eMagRes

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Proton magnetic resonance spectroscopy ( 1 H MRS) of biological systems has higher specificity than MRI because resonances of multiple metabolites can be distinguished, reflecting chemistry and physiology in situ. Unfortunately, this approach has very low sensitivity as the metabolites are typically at millimolar concentrations compared to the molar signal strength of water-based MRI. As a consequence, even though 1 H MRS is a powerful and common research tool, its inroad into daily clinical practice has been limited. Until very recently, 1 H MRS applications have focused on the resonances upfield (i.e., at lower frequency) of the water resonance. This article deals with protons that are generally not observed in a typical water-suppressed spectrum, namely, the exchangeable protons found predominantly downfield from water. These can usually be detected by MRS only if the transfer of water proton saturation (established during water suppression) is not a confounding factor, or by using water exchange (WEX) spectroscopy, in which RF labeling of the water protons is transferred to the exchangeable protons and subsequently detected. More importantly, it has recently become clear that the presence of such exchangeable protons on low concentration solute molecules can be detected via the water signal by RF labeling of these protons and subsequent transfer of this label to water protons. This process, leading to saturation of the water signal and enhancement of the effect through repeated exchange, can be used for the imaging of metabolite signals or exchangeable-proton-based contrast agents with enhanced sensitivity. This has given rise to the field of chemical exchange saturation transfer (CEST) MRI, which has greatly increased the potential for translating spectroscopic methods to the clinic. Examples include the measurement of pH, temperature, and enzyme activity as well as detection of cellular metabolites, ions, and proteins and peptides. In addition, bio-organic compounds can now be used for contrast agents, cell and nanoparticle labeling, and reporter genes.

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Chemical Exchange Saturation Transfer (CEST) MR Technique for Liver Imaging at 3.0 Tesla: an Evaluation of Different Offset Number and an After-Meal and Over-Night-Fast Comparison

Cited by 33 publications

References 48 publications

Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model

Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model

Real‐time simultaneous shim and motion measurement and correction in glycoCEST MRI using double volumetric navigators (DvNavs)

Proton Chemical Exchange Saturation Transfer (CEST) MRS and MRI

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