Chemical Modification of Polyhydroxyalkanoates (PHAs) for the Preparation of Hybrid Biomaterials

Bassas-Galià, Mònica; González, Adolfo Hidalgo; Micaux, Fabrice; Gaillard, Vanessa; Piantini, Umberto; Schintke, Silvia; Zinn, Manfred; Mathieu, Marc

doi:10.2533/chimia.2015.627

Cited by 18 publications

(10 citation statements)

References 7 publications

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“…PHA utilisation in biomedical research is extensive due to its biocompatibility for a number of tissue types. Several aspects have been considered, including wound healing patches [ 266 ], bioresorbable sutures [ 267 , 268 ], drug delivery [ 269 ], as well as in scaffold development [ 257 ] for tissue engineering applications [ 270 , 271 ]. These applications mostly benefit from the elastomeric property of PHAs, especially mcl-PHAs [ 270 , 272 , 273 ].…”

Section: The History Contemporary Status and Future Applicationsmentioning

confidence: 99%

Biomedical Applications of Bacteria-Derived Polymers

et al. 2021

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Plastics have found widespread use in the fields of cosmetic, engineering, and medical sciences due to their wide-ranging mechanical and physical properties, as well as suitability in biomedical applications. However, in the light of the environmental cost of further upscaling current methods of synthesizing many plastics, work has recently focused on the manufacture of these polymers using biological methods (often bacterial fermentation), which brings with them the advantages of both low temperature synthesis and a reduced reliance on potentially toxic and non-eco-friendly compounds. This can be seen as a boon in the biomaterials industry, where there is a need for highly bespoke, biocompatible, processable polymers with unique biological properties, for the regeneration and replacement of a large number of tissue types, following disease. However, barriers still remain to the mass-production of some of these polymers, necessitating new research. This review attempts a critical analysis of the contemporary literature concerning the use of a number of bacteria-derived polymers in the context of biomedical applications, including the biosynthetic pathways and organisms involved, as well as the challenges surrounding their mass production. This review will also consider the unique properties of these bacteria-derived polymers, contributing to bioactivity, including antibacterial properties, oxygen permittivity, and properties pertaining to cell adhesion, proliferation, and differentiation. Finally, the review will select notable examples in literature to indicate future directions, should the aforementioned barriers be addressed, as well as improvements to current bacterial fermentation methods that could help to address these barriers.

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Section: The History Contemporary Status and Future Applicationsmentioning

confidence: 99%

Biomedical Applications of Bacteria-Derived Polymers

et al. 2021

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“…The double bonds caused unwanted intramolecular crosslink reactions; therefore, epoxidation was carried out. The conversion led to the obtaining of two new polymer chains, each with epoxy groups and the rate of conversion was determined to be about 80% in 1 h [ 49 ]. Chlorination is a process that involves the passage of chlorine gas through P3HB and poly(3-hydroxyoctanoate) (PHO) for modifying their properties.…”

Section: Chemical Modification For Enhancement Of Functional Propementioning

confidence: 99%

Microbial Polyhydroxyalkanoates Granules: An Approach Targeting Biopolymer for Medical Applications and Developing Bone Scaffolds

et al. 2021

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Microbial polyhydroxyalkanoates (PHA) are proteinaceous storage granules ranging from 100 nm to 500 nm. Bacillus sp. serve as unique bioplastic sources of short-chain length and medium-chain length PHA showcasing properties such as biodegradability, thermostability, and appreciable mechanical strength. The PHA can be enhanced by adding functional groups to make it a more industrially useful biomaterial. PHA blends with hydroxyapatite to form nanocomposites with desirable features of compressibility. The reinforced matrices result in nanocomposites that possess significantly improved mechanical and thermal properties both in solid and melt states along with enhanced gas barrier properties compared to conventional filler composites. These superior qualities extend the polymeric composites’ applications to aggressive environments where the neat polymers are likely to fail. This nanocomposite can be used in different industries as nanofillers, drug carriers for packaging essential hormones and microcapsules, etc. For fabricating a bone scaffold, electrospun nanofibrils made from biocomposite of hydroxyapatite and polyhydroxy butyrate, a form of PHA, can be incorporated with the targeted tissue. The other methods for making a polymer scaffold, includes gas foaming, lyophilization, sol–gel, and solvent casting method. In this review, PHA as a sustainable eco-friendly NextGen biomaterial from bacterial sources especially Bacillus cereus, and its application for fabricating bone scaffold using different strategies for bone regeneration have been discussed.

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“…To give PHAs new and unique properties, several multiphase materials have been developed, mainly by mixing PHB or P(HBco-HV) with other products such as plasticizers, fillers, or other polymers (Visakh and Roy, 2015). The structure of a PHA can be modified to obtain a polymer with desired properties for niche applications by chemical processes such as carboxylation, hydroxylation, epoxidation, chlorination, and grafting reaction (Figure 5) (Hazer and Steinbüchel, 2007;Bassas-Galià et al, 2015;Antwi Peprah et al, 2018). Kwon et al, 2007 FIGURE 5 | Modification of a polyhydroxyalkanoate (PHA) structure through selected chemical reactions.…”

Section: Processing and Modifications Of Polyhydroxyalkanoate Polymersmentioning

confidence: 99%

What Has Been Trending in the Research of Polyhydroxyalkanoates? A Systematic Review

Guzik

Witko

Steinbüchel

et al. 2020

Front. Bioeng. Biotechnol.

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Over the past decades, enormous progress has been achieved with regard to research on environmentally friendly polymers. One of the most prominent families of such biopolymers are bacterially synthesized polyhydroxyalkanoates (PHAs) that have been known since the 1920s. However, only as recent as the 1990s have extensive studies sprung out exponentially in this matter. Since then, different areas of exploration of these intriguing materials have been uncovered. However, no systematic review of undertaken efforts has been conducted so far. Therefore, we have performed an unbiased search of up-to-date literature to reveal trending topics in the research of PHAs over the past three decades by data mining of 2,227 publications. This allowed us to identify eight past and current trends in this area. Our study provides a comprehensive review of these trends and speculates where PHA research is heading.

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Chemical Modification of Polyhydroxyalkanoates (PHAs) for the Preparation of Hybrid Biomaterials

Cited by 18 publications

References 7 publications

Biomedical Applications of Bacteria-Derived Polymers

Biomedical Applications of Bacteria-Derived Polymers

Microbial Polyhydroxyalkanoates Granules: An Approach Targeting Biopolymer for Medical Applications and Developing Bone Scaffolds

What Has Been Trending in the Research of Polyhydroxyalkanoates? A Systematic Review

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