With the continuous warming of semiconductor research, sto has become a candidate to construct a new memristor structure due to its resistance switching phenomenon. By doping sto with metal, researchers can replace SR or Ti elements in sto. For example, sto doped with Nb, Nd, La and other elements becomes an n-type semiconductor. More and more researchers have paid attention to metal doped sto materials. Therefore, the preparation process of strontium niobate doped (SND) single crystals is researched and developed in this paper. Firstly, the optimization and mechanism of hydrothermal synthesis of strontium titanate were studied, and then the preparation process of strontium titanate doped with niobium was analyzed; Finally, the sto single crystal samples doped with 0.05%wt and 0.7%wtnb were characterized. Hall test showed that the single crystal was a donor doped semiconductor. The electrical performance test showed that the strontium niobate single crystal had excellent resistance.