Chemical profile and defensive function of the latex of Euphorbia peplus

Jin, Hua; Liu, Yan; Xiao, Chao‐Jiang; Jing, Shu-Xi; Luo, Shi‐Hong; Li, Shenghong

doi:10.1016/j.phytochem.2016.12.021

Cited by 53 publications

(41 citation statements)

References 28 publications

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“…Previous phytochemical investigation has revealed that diterpenoids, including jatrophane, ingenane, lathyrane types, were the major constituents of genus Euphorbia . Biological study on these macrocyclic diterpenoids has revealed their broad pharmacological especially cytotoxic, antimicrobial, and anti‐inflammatory activities, as well as defensive roles . In this work, three new compounds, belonging to jatrophane ( 1 and 2 ) and lathyrane ( 3 ) diterpenoids, were isolated from the whole plant of E. helioscopia .…”

Section: Resultsmentioning

confidence: 93%

“…Since the macrocyclic diterpenoids showed potent antifeedant activity against the generalist plant‐feeding insect Helicoverpa armigera and functioned as constitutive defense metabolites for E. peplus , it was interesting to know whether these compounds with similar structures also play the same function in E. helioscopia . Compounds 1 – 3 were therefore tested for their antifeedant activity against H. armigera .…”

Section: Resultsmentioning

confidence: 99%

“…S18), coupling constant pattern, and chemical shifts of chrial carbons of 3 indicated that the relative configurations of all stereogenic centers in 3 were the same as those in altotibetol. Consequently, compound 3 was identified as 15b-acetoxy-7b-(benzoyloxy)-3b-hydroxy-14-oxolathyra-5E,12E-diene and was named euphoscopoid C. Since the macrocyclic diterpenoids showed potent antifeedant activity against the generalist plant-feeding insect Helicoverpa armigera and functioned as constitutive defense metabolites for E. peplus, [21] it was interesting to know whether these compounds with similar structures also play the same function in E. helioscopia. Compounds 1 -3 were therefore tested for their antifeedant activity against H. armigera.…”

Section: Resultsmentioning

confidence: 99%

“…[1] [2] Biological study on these macrocyclic diterpenoids has revealed their broad pharmacological especially cytotoxic, antimicrobial, and anti-inflammatory activities, as well as defensive roles. [1 -3] [21] In this work, three new compounds, belonging to jatrophane (1 and 2) and lathyrane (3) diterpenoids, were isolated from the whole plant of E. helioscopia. Although cytotxoic activity of jatrophane and lathyrane diterpenoids from Euphorbia has been reported, [14][19] [22] only compound 2 was moderately active while the other two compounds were inactive, therefore the apoptosis and other related mechanisms of these diterpenoids were not investigated.…”

Section: Resultsmentioning

confidence: 99%

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New Bioactive Macrocyclic Diterpenoids from Euphorbia helioscopia

Jin

Luo

Liu

et al. 2017

Chemistry & Biodiversity

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Three new macrocyclic diterpenoids, euphoscopoids A - C (1 - 3), including two new jatrophanes and a new lathyrane, were isolated from the whole plant of Euphorbia helioscopia. Their structures were elucidated by spectroscopic methods. Antifeedant and cytotoxic activities of these isolates were evaluated. All compounds showed significant antifeedant activity against a generalist plant-feeding insect, Helicoverpa armigera, with EC values ranging from 2.05 to 4.34 μg/cm . In addition, compound 2 showed moderate cytotoxicity against tumor cell lines NCI-H1975, HepG2, and MCF-2, while compounds 1 and 3 were not active at 80 μm. The results suggested not only the defensive function of macrocyclic diterpenoids in E. helioscopia against insect herbivores, but also their potential applications as new natural insect antifeedants.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

New Bioactive Macrocyclic Diterpenoids from Euphorbia helioscopia

Jin

Luo

Liu

et al. 2017

Chemistry & Biodiversity

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“…The lowest calcium, magnesium and fine sand content was recorded in this group. E. peplus was reported by many authors to have therapeutic effect and its secondary metabolites can work as anti skin cancer (Ramsay et al (2011);Hua et al (2017) and lishmanicidal (Amin et al, 2017). Ates and Tekeli (2007) reported the salinity tolerance of T. resupinatum.…”

Section: Group 4: Euphorbia Peplus -Trifolium Resupinatummentioning

confidence: 99%

Habitat diversity and plant indicators of El-Harra Oasis, Western Desert, Egypt

Elsaied¹

2017

Int. J. Adv. Res. Biol. Sci

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Habitat diversity is one of the attractive concepts in ecology that reflects the wellbeing of ecological systems. A total of 30 stands were chosen to represent habitat diversity of El-Harra Oasis. Poaceae, fababceae and astraceae were the most common families with 33 species out of 79 species belonging to 29 families. Therophytes and Hemicryptophytes were the most common life forms with 72 % of the species recorded. Chorology of all non-cultivated taxa was investigated. Species richness, Shannon and Simpson diversity indices and evenness was calculated for each stand. Eighteen soil parameters were investigated and results showed large variation among stands. Seven vegetation groups were obtained from the Two-way cluster analysis classification. Environmental parameters correlation with vegetation groups were determined using DCA and DCCA. Significant factors were detected by one way analysis of variance among the seven vegetation groups. Results showed that soil salinity indicators, soil moisture content and soil particles were the most critical factors affecting the ecological diversity in El-Harra Oasis. Indicator species of the seven habitats were halotolreants or halophytes. Managing water resources and agriculture schemes should reduce the magnitudes of salinity problem in El-Harra Oasis.

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