Chemical profiling and antiproliferative effect of essential oils of two Araucaria species cultivated in Egypt

Elkady, Wafaa M.; Ayoub, Iriny M.

doi:10.1016/j.indcrop.2018.03.051

Cited by 40 publications

(71 citation statements)

References 44 publications

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“…Many of the compounds identified in setubalense and murcott tangerines have been previously reported with a myriad of bioactivities. This includes antioxidant [ 17 , 18 , 19 , 20 ], anti-inflammatory [ 17 ], antidiabetic [ 19 , 21 ], antileishmanial [ 22 , 23 ], antimicrobial [ 19 , 22 , 24 , 25 ], cytotoxic [ 22 , 23 ], antitumor [ 26 ], and antiproliferative activities [ 27 , 28 ]. Furthermore, there are evidence pointing to other protective effects against Alzheimer’s [ 29 ] and tuberculosis [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Tangerines Cultivated on Madeira Island—A High Throughput Natural Source of Bioactive Compounds

Figueira

Porto-Figueira

Câmara

2020

Foods

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Tangerines (Citrus reticulata) are popular fruits worldwide, being rich in many bioactive metabolites. The setubalense variety cultivated on Madeira Island has an intense aroma easily distinguishable from other tangerines, being traditionally used to enrich several foods and beverages. Nonetheless, setubalense volatile composition has never been characterized, and we aimed to unveil the bioactive potential of peels and juices of setubalense tangerines and compare them with the murcott variety grown in Portugal mainland. Using headspace solid-phase microextraction coupled to gas chromatography mass spectrometry (HS-SPME/GC-MS), we identified a total of 128 volatile organic metabolites (VOMs) in the juice and peels, with d-limonene, γ-terpinene, β-myrcene, α- and β-pinene, o-cymene, and terpinolene, the most dominant in both cultivars. In contrast, setubalense juices are richer in terpenes, many of them associated with health protection. Discriminant analysis revealed a pool of VOMs, including β-caryophyllene and E-ocimene, with bioactive properties able to differentiate among tangerines according to variety and sample type (peel vs. juice). This is the first report on the volatile composition of setubalense tangerines grown on Madeira Island revealing that its pungent aroma is constituted by secondary metabolites with specific aroma notes and health properties. This is strong evidence of the higher nutraceutical value of such fruit for the human diet.

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Section: Resultsmentioning

confidence: 99%

Tangerines Cultivated on Madeira Island—A High Throughput Natural Source of Bioactive Compounds

Figueira

Porto-Figueira

Câmara

2020

Foods

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“…Essential oil components were tentatively identified by comparison of their mass spectra and retention indices with those listed in NIST Mass Spectral Library, 2011; Wiley Registry of Mass Spectral Data 8 th edition; and data reported in literature [11–13].…”

Section: Methodsmentioning

confidence: 99%

“…The anti-proliferative activity of the essential oils was assessed against HCT-116 and Hela human cancer cell lines using MTT assay [13, 18]. Exponentially growing cells were seeded at a density of 10×10 4 cells/well (HCT-116) and 15 x10 4 cells/well (Hela) in 96-well plates.…”

Section: Methodsmentioning

confidence: 99%

Phytochemical profiling and seasonal variation of essential oils of three Callistemon species cultivated in Egypt

Gad

Ayoub

2019

PLoS ONE

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The genus Callistemon comprises evergreen shrubs or small trees, widely cultivated as ornamentals and for essential oil production. Callistemon is well-recognized in folk medicine for its anti-cough, anti-bronchitis, and insecticidal activities. In the current study, we profiled the essential oil composition of the leaves of C . citrinus , C . rigidus and C . viminalis (Myrtaceae) collected during different seasons by GLC-MS coupled to multivariate data analysis. Antioxidant, anti-inflammatory and anti-proliferative activities of Callistemon essential oils were evaluated. A total of 29 compounds were tentatively identified. Oxygenated monoterpenes dominated in essential oils, where eucalyptol represented the major constituent in the three Callistemon species in all seasons. Multivariate data analysis including Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA) were applied to discriminate between different Callistemon species in each season and to investigate any correlation between the metabolic profile of each species within different seasons. As expected, PCA plot could discriminate the three Callistemon species in the four seasons. The dendrogram from HCA confirmed the results of PCA as it showed the same segregation pattern regarding the discrimination of different Callistemon species. C . viminalis showed more pronounced antioxidant activity than C . citrinus , exhibiting IC 50 values of 1.40 mg/mL and 1.77 mg/mL, respectively. Meanwhile, C . rigidus showed very weak antioxidant activity. All oils showed membrane stabilization activity in hypotonic solution induced haemolysis assay, where C . viminalis showed potent membrane stabilizing activity exhibiting IC 50 value of 25.6 μg/mL comparable to that of the standard drug, indomethacin (17.02 μg/mL). Nevertheless, Callistemon essential oils were not cytotoxic in HCT-116 and Hela human cancer cell lines.

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“…The first generation of P-gp inhibitors included verapamil, trifluoperazine, cyclosporine-A, quinidine, reserpine, vincristine, yohimbine, tamoxifen, and toremifene, which are all competitive substrates of P-glycoprotein [3]. Natural compounds isolated from medicinal plants are promising leads in the development of novel chemotherapeutic agents [4]. Euryops pectinatus (L.) Cass (Asteraceae) is native to South Africa and is widely used as an ornamental plant.…”

Section: Introductionmentioning

confidence: 99%

Euryops pectinatus L. Flower Extract Inhibits P-glycoprotein and Reverses Multi-Drug Resistance in Cancer Cells: A Mechanistic Study

et al. 2020

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Euryops pectinatus is a South African ornamental plant belonging to family Asteraceae. The present work evaluates the cytotoxic activity and phytochemical profile of the flower extract. Metabolite profiling was performed using HPLC-PDA-ESI-MS/MS. Total phenolics and flavonoids content were assessed. Cytotoxicity was evaluated against 6 different cancer cell lines using MTT assay. The possible underlying mechanism was proposed. We analyzed whether the extract could overcome the resistance of multidrug-resistant cancer cells for doxorubicin. The effect of combination of E. pectinatus with doxorubicin was also studied. Additionally, the potential inhibitory activity of the identified phytochemicals to PB1 protein was analyzed using in silico molecular docking. Twenty-five compounds were tentatively identified. Total phenolic and flavonoid contents represented 49.41 ± 0.66 and 23.37 ± 0.23 µg/mg dried flower extract, respectively. The extract showed selective cytotoxicity against Caco2 cells but its main effect goes beyond mere cytotoxicity. It showed strong inhibition of P-glycoprotein, which helps to overcome multidrug resistance to classical chemotherapeutic agents. In silico molecular docking showed that dicaffeoyl quinic acid, kaempferol-O-rutinoside, rutin, and isorhamnetin-O-rutinoside exhibited the most potent inhibitory activity to PB1 involved in tumor progression. Euryops pectinatus flower heads could have promising selective cytotoxicity alone or in combination with other chemotherapeutic agents to counteract multidrug resistance.

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Chemical profiling and antiproliferative effect of essential oils of two Araucaria species cultivated in Egypt

Cited by 40 publications

References 44 publications

Tangerines Cultivated on Madeira Island—A High Throughput Natural Source of Bioactive Compounds

Tangerines Cultivated on Madeira Island—A High Throughput Natural Source of Bioactive Compounds

Phytochemical profiling and seasonal variation of essential oils of three Callistemon species cultivated in Egypt

Euryops pectinatus L. Flower Extract Inhibits P-glycoprotein and Reverses Multi-Drug Resistance in Cancer Cells: A Mechanistic Study

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