Chemical profiling and biological properties of Neolitsea kedahense Gamble essential oils

Abstract

Hydrodistillation of the fresh stem and leaf of Neolitsea kedahense Gamble, collected from Gunung Jerai, Malaysia followed by the GC-FID and GC-MS analysis revealed the detection of a total of 47 constituents of which 28 (86.4%) from the stem and 31 (96.4%) constituents from the leaf. δ-Cadinene (17.4%), 1-epi-cubenol (11.8%), cyperotundone (9.0%), cis-cadin-4-en-7-ol (7.7%), τ-cadinol (7.1%) and α-cadinol (7.1%) were the principle constituents in the stem oil, whereas β-caryophyllene (18.9%), bicyclogermacrene (18.6%) and trans-muurola-4(14),5-diene (9.8%) were the major constituents in the leaf oil. Among the identified constituents, three constituents namely 7-epi-α-selinene, junenol and cis-cadin-4-en-7-ol have not been found previously from Neolitsea oils. The stem and leaf oils were screened for their α-glucosidase inhibitory and antibacterial activities. Both oils displayed potential α-glucosidase inhibitory activity, while the stem oil possessed weak antibacterial activity against Bacillus subtilis.

Phytochemical profiling of the essential oils from three Curcuma species and their in vitro and in silico dengue protease inhibition activity

“…The peak areas and retention times were measured by electronic integration. The injections were performed in three replications (Jani et al 2017).…”

“…The retention indices of the compounds were identified relative to the retention times of a series of n-alkanes (C6-C28). The relative proportions of the compounds were percentages obtained by peakarea normalization, with all relative response factors being taken as one (Jani et al 2017).…”

Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications

“…var. pungens [ 89 ], Rhaponticum acaule (L.) DC [ 90 ], Acacia mollissima and Acacia cyclops [ 91 ] and Neolitsea kedahense Gamble [ 92 ] and Senna podocarpa (Guill. and Perr.)…”

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“…In E. arvense, Radulovic et al, 18 also reported trans-phytol as a major component but in a relatively lesser amount (10.06%). Cis-cadin-4-ene-7-ol (5.32%), which also contribute a major proportion of essential oil of E. diffusum, was previously suggested responsible for the antimicrobial activity 35,36 . This oxygenated bicyclic sesquiterpene has also been reported from some angiosperms, Neolitsea kedahense-7.7% 36 , Achillea coarctata 37 , but this is the first report from pteridophyte.…”

“…Cis-cadin-4-ene-7-ol (5.32%), which also contribute a major proportion of essential oil of E. diffusum, was previously suggested responsible for the antimicrobial activity 35,36 . This oxygenated bicyclic sesquiterpene has also been reported from some angiosperms, Neolitsea kedahense-7.7% 36 , Achillea coarctata 37 , but this is the first report from pteridophyte. Kanchanapoom et al, studied the chemical composition of the aerial portion of E. diffusum growing in Thailand, by using 1 H-NMR and 13 C-NMR and four compounds, sammangaoside A, kaempferol 3-O-sophoroside, L-tryptophan and (3S, 5R, 6S, 7E, 9S)-megastigman-7-ene-5,6epoxy-3,9-diol 3-O-b -D-glucopyranoside were identified 38 .…”