Chemical Sensing Platforms Based on Organic Thin-Film Transistors Functionalized with Artificial Receptors

Kubota, Riku; Sasaki, Yoko; Minamiki, Tsukuru; Minami, Tsuyoshi

doi:10.1021/acssensors.9b01114

Cited by 70 publications

(64 citation statements)

References 183 publications

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“…Thus, we developed Glc sensors based on organic field‐effect transistors (OFETs) to exploit the features of mechanical flexibility, biocompatibility, low‐cost, and solution‐processability . Furthermore, the combination of supramolecular artificial receptors and OFETs can offer robust, thermally and chemically stable sensing systems for long‐term use . A number of prior publications reported that an artificial lectin, phenylboronic acid (PBA), is one of the most appropriate receptors for glucose detection .…”

Section: Figurementioning

confidence: 99%

“…[25,26] Furthermore, the combination of supramolecular artificial receptors and OFETs can offer robust, thermally and chemically stable sensing systems for long-term use. [27] A number of prior publications reported that an artificial lectin, phenylboronic acid (PBA), is one of the most appropriate receptors for glucose detection. [28][29][30] Thus far, such OFET-based chemical sensors have been mainly designed for point-of-care testing.…”

Section: Microfluidic System With Extended-gate-type Organic Transistmentioning

confidence: 99%

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Microfluidic System with Extended‐Gate‐Type Organic Transistor for Real‐Time Glucose Monitoring

et al. 2020

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Organic field‐effect transistors (OFETs) can be potentially employed to monitor cell activities for healthcare and medical treatment because of their attractive properties such as ease of use, flexibility, and low‐cost manufacturing processes. Although current OFET‐based sensors are suitable for point‐of‐care testing, the establishment of real‐time monitoring methods is in high demand for continuous monitoring of health conditions and/or biological cell activities. In this regard, we herein propose a microfluidic platform integrated with an extended‐gate‐type OFET for real‐time glucose monitoring. The mechanism of glucose detection depends on the artificial receptor phenylboronic acid and its boronate esterification. After optimization of the microfluidics for the OFET‐based sensor, the sensor was used to monitor glucose consumption and release in a model of pseudo‐liver cells. Random increases or decreases in the glucose concentration were reproducibly monitored.

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Section: Figurementioning

confidence: 99%

Section: Microfluidic System With Extended-gate-type Organic Transistmentioning

confidence: 99%

Microfluidic System with Extended‐Gate‐Type Organic Transistor for Real‐Time Glucose Monitoring

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“…This means that external apparatuses are not required for the detection of analytes in FET-based sensors. Hence, FET devices are one of the best candidate platforms for the development of on-site chemical sensing systems [80]. However, amplification mechanisms for the analyte information should be introduced into the FET device because the sensitivity of the FET-based sensors is generally restricted by the Debye shielding effect [81].…”

Section: Electrochemical/electrical Detection Of Analytes For the Achmentioning

confidence: 99%

“…This means that external apparatuses are not required for the detection of analytes in FET-based sensors. Hence, FET devices are one of the best candidate platforms for the development of on-site chemical sensing A gate electrode is usually utilized as a sensing portion in the FETs since the introduction of the molecular assemblies is easily achievable [80]. Wipf et al reported the selective detection of sodium (Na + ) by using a silicon nanowire FET modified with a 15-crown-5-ether monolayer [48].…”

Section: Electrochemical/electrical Detection Of Analytes For the Achmentioning

confidence: 99%

The Power of Assemblies at Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes

Minamiki

Ichikawa

Kurita

2020

Sensors

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Synthetic sensing materials (artificial receptors) are some of the most attractive components of chemical/biosensors because of their long-term stability and low cost of production. However, the strategy for the practical design of these materials toward specific molecular recognition in water is not established yet. For the construction of artificial material-based chemical/biosensors, the bottom-up assembly of these materials is one of the effective methods. This is because the driving forces of molecular recognition on the receptors could be enhanced by the integration of such kinds of materials at the 'interfaces', such as the boundary portion between the liquid and solid phases. Additionally, the molecular assembly of such self-assembled monolayers (SAMs) can easily be installed in transducer devices. Thus, we believe that nanosensor platforms that consist of synthetic receptor membranes on the transducer surfaces can be applied to powerful tools for high-throughput analyses of the required targets. In this review, we briefly summarize a comprehensive overview that includes the preparation techniques for molecular assemblies, the characterization methods of the interfaces, and a few examples of receptor assembly-based chemical/biosensing platforms on each transduction mechanism.Synthetic receptors (i.e., artificial molecular recognition materials) are some of the most suitable platform materials for the development of chemical/biosensors owing to their chemical/physical stability, low cost of production, and their fine-tuning ability to select the required targets [4]. However, the preparation of artificial receptor-based sensors for practical applications is still in its initial stages, since the analyte specificity of most of the artificial materials is generally lower than that of biomaterials (i.e., antibodies and enzymes) [5]. To improve the binding affinity between the artificial receptors and the analytes, complicated synthesis procedures are required. Hence, a simpler way to improve the sensing ability of the artificial receptors should be considered to bring out the attractive features of these materials. To facilitate this, bottom-up integration of the receptors as molecular assemblies is considered as one of the most useful approaches for the construction of selective sensing fields for analytes. Moreover, the sensing features in the artificial receptor-based sensors could be finely tuned by using top-down technologies (e.g., molecular imprinting techniques [6], etc.) because the molecular recognition ability of the receptor assemblies depends on their nanostructures [7]. As aforementioned, the molecular assembly enhances the functions of a single kind of molecule ( Figure 1) [8]. In addition, the driving forces in molecular recognition (i.e., noncovalent interactions) can be amplified at the interfaces such as the boundary portion between the liquid and solid phases [9,10]. Thus, we believe that the installation of artificial receptors at the surface of the sensing portion in selective transducer...

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“…For instance, we have constructed the extended‐gate type OFETs for protein sensing by employing a hybrid‐type ultra‐thin dielectric film which consists of an oxide film and a self‐assembled monolayer (SAM) material . More details of the fabrication process and applied materials for the extended‐gate type OFETs are summarized in a recent review article …”

Section: Device Design Of Ofets For the Accurate And Reproducible Detmentioning

confidence: 99%

Protein Assays on Organic Electronics: Rational Device and Material Designs for Organic Transistor‐Based Sensors

et al. 2020

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Artificial receptor-based protein assays have various attractive features such as a long-term stability, a low-cost production process, and the ease of tuning the target specificity. However, such protein sensors are still immature compared with conventional immunoassays. To enhance the application potential of synthetic sensing materials, organic field-effect transistors (OFETs) are some of the suitable platforms for protein assays because of their solution processability, durability, and compact integration. Importantly, OFETs enable the electrical readout of the protein recognition phenomena of artificial receptors on sensing electrodes. Thus, we believe that OFETs functionalized with artificial protein receptors will be a powerful tool for the on-site analyses of target proteins. In this Minireview, we summarize the recent progress of the OFET-based protein assays including the rational design strategies for devices and sensing materials.[a] Dr.

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Chemical Sensing Platforms Based on Organic Thin-Film Transistors Functionalized with Artificial Receptors

Cited by 70 publications

References 183 publications

Microfluidic System with Extended‐Gate‐Type Organic Transistor for Real‐Time Glucose Monitoring

Microfluidic System with Extended‐Gate‐Type Organic Transistor for Real‐Time Glucose Monitoring

The Power of Assemblies at Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes

Protein Assays on Organic Electronics: Rational Device and Material Designs for Organic Transistor‐Based Sensors

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