Chemical Structures and Cell Death Inducing Activities of Constituents Isolated from Hibiscus tiliaceus

Abstract

A new coumarin glycoside hibiscuscoumarin (1) was obtained with ten known compounds including seguinoside K (7) from the stems and twigs of Hibiscus tiliaceus. The structure of hibiscuscoumarin (1) was elucidated based on the chemical/physicochemical evidence. The cell death-inducing activities of the isolated compounds with or without Adriamycin (ADR) were observed using time-lapse cell imaging. The isolated compounds did not affect the number of mitotic entry cells and dead cells. Otherwise, the treatment of cells with seguinoside K (7) significantly increased the number of dead cells induced by ADR.