Chemical structures of macrocyclic bis(bibenzyls) isolated from liverworts (Hepaticae)

Abstract

Liverworts (Hepaticae) produce a number of macrocyclic bis(bibenzyls) which show interesting biological activity and are of very valuable for the chemosystematic study of liverworts. The structural elucidation of these characteristic natural products are reviewed.

Marchantin C: A potential anti-invasion agent in glioma cells

“…10 Studies and clinical trials have demonstrated that marchantin C has antibacterial, antifungal, and antioxidant properties, 6,7 as well as suppression of the growth of several cancer cells, such as A172, K562 and HepG2. 9 In the present study, we focused our main scope on the anti-invasiveness and anti-angiogenic activity Recovery of each denuded area was quantified by densitometric analyses relative to that of the control which was set at 100% as shown in the graph.…”

“…It has been demonstrated to exhibit multiple pharmacological activities such as antimicrobial activity against the Grampositive bacterium Bacillus subtilis, 6 antioxidant activity to free radicals, 5 and anti-tumor activity against A172 glioma cells. 8 Recently, we found that marchantin C abrogated microtubule dynamics and mitotic spindle formation, resulting in cell cycle arrest at G 2 /M phase and eventually leading to cell death both in vitro and in vivo.…”

“…More and more attention is being paid to them because of their wide range of biological activities including cytotoxicity and antibacterial and antifungal activity. 6,7 Cancer cell migration is a leading cause of tumor recurrence and treatment failure. Previously, we reported that marchantin C exhibited promising antitumor activity by inducing microtubule depolymerization and apoptosis.…”

An Evaluation of the Antibacterial and Antiviral Activities of Some Bryophytes

“…The antibacterial activity of flavonoids has been reported (Singh & Bhat, 2003). Asakawa (1990Asakawa ( , 2001 and Asakawa et al (2000) stated that almost all species of bryophytes are not damaged by insect larvae, fungi, bacteria, slugs, snails and mammals because, biological compounds like oligosaccharides, polysaccharides, sugar alcohols, amino acids, fatty acids, aliphatic compounds, phenyl quinone and aromatic phenolic substances in bryophytes are protected against these organisms. It is well known that plant phenols, particularly the free phenols (whichare toxic substances) play a significant role in controlling pathogenic microorganisms attacking some variety of plants.…”

Overcoming of P-glycoprotein-mediated multidrug resistance in K562/A02 cells using riccardin F and pakyonol, bisbibenzyl derivatives from liverworts

“…Bisbibenzyls, a class of plant metabolites produced exclusively in liverworts, is a family of phenolic compounds belonging to stilbenoids (9). They have attracted more attention for their wide-range of bioactivity and medicinal potency, including antibacterial, antifungic, antioxidative, muscle-relaxing and cytotoxic activities as well as inhibitory effects on 5-lipoxygenase, cyclooxygenase and calmodulin (10).…”