2019
DOI: 10.17816/maj191s1169-170
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Chemical Synthesis and Analysis of Antimicrobial and Hemolytic Activity of Structural Analogous of a Peptide Protegrin 1

Abstract: Search for new tools for combating infectious diseases and investigation of molecular mechanisms of their antimicrobial action in in vitro and in vivo models are the urgent tasks of experimental medicine and pathophysiology. A promising direction for the development of new effective antibiotic drugs is creation of analogues of natural protective molecules that provide a host defense against pathogenic bacteria, in particular analogues of antimicrobial peptides of the innate immune system. The aim of our work w… Show more

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