Chemically synthesized Schiffs base Conjugated Piperonal as novel Antioxidants and Scavengers of Free Radicals

Abstract

Ethylene diamine is an organic compound which is a strongly basic amine and is used to conjugate Piperonal, an heterocyclic aldehyde. The ethylene diamine conjugated piperonal was prepared using simple method and the antioxidant assays like DPPH, ABTS, Ferric reducing assay and several other methods were carried out through in vitro assays. The experiments were carried out with unconjugated piperonal and compared with the activity shown by the test sample. The overall result shows a good antioxidant effect when compared with various standard drugs such as ascorbic acid, gallic acid, BHT etc., Hence, the results proved that, conjugated piperonal can be used as antioxidants in scavenging free radicals generated as consequence of various disease condition. Further, the synthesised compound can be explored for various experimental studies to confirm their role in combating various diseases.

Molecular Docking Analysis of Piperonal and its Analogues as Promising Cancer Therapeutics by Modulating Angiogenesis

“…The structure of piperonal forms the basis for the synthesis of various chalcones and flavonoids. The study reported potent antioxidant free radical scavenging potential of piperonal and EDP schiffs base linked piperonal 14 . However, the piperonal and its structural analogues were not explored for the down regulation of VEGFR targeting angiogenesis.…”