Chemiluminescence and Toluidine Blue as Diagnostic Tools for Detecting Early Stages of Oral Cancer: An invivo Study

Vashisht, Neha Vashisht Dr. Neha; Ravikiran, A; Samatha, Y; Rao, Purna Chandra; Naik, Ravindra; Vashisht, Divy

doi:10.7860/jcdr/2014/7746.4259

Cited by 20 publications

(28 citation statements)

References 21 publications

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“…The positive predictive value and negative predictive value were 86.36% and 76.9%. 28 The present study is not in concordance with study conducted by Onofre et al, who reported sensitivity and specificity for toluidine blue in oral malignant lesions to be 100% and 65% respectively. 29 Rodriguez et al reported the sensitivity and specificity for detection of oral malignant/premalignant lesions to be 65.5% and 73.3% respectively.…”

Section: Discussioncontrasting

confidence: 99%

The study of use of toluidine blue as an adjunctive tool to clinical examination in early diagnosis of clinically suspicious oral premalignant and malignant lesions: a study of fifty cases

Bayad

Bhagat

Sahni

et al. 2019

Int J Otorhinolaryngol Head Neck Surg

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Background: Oral carcinoma is among the most prevalent malignancies of head and neck region and is often diagnosed in the advanced stage with significant morbidity and treatment cost. Thus, there is a need for early detection of oral premalignant and malignant lesions. Toluidine blue staining can be used for early detection of these lesions.Methods: The study included 50 patients with clinically suspicious oral premalignant and malignant lesions. These lesions were subjected to toluidine blue staining and biopsy. Diagnoses were confirmed by histopathological examination. Results: Sensitivity and specificity of toluidine blue for oral premalignant lesions was 92.30% and 80% respectively with the positive predictive value of 92.30%, negative predictive value of 80% and accuracy of 88.88%. Sensitivity and specificity of toluidine blue for oral malignant lesions was 96.30% and 80% respectively with the positive predictive value of 96.30%, negative predictive value of 80% and accuracy of 93.75%.Conclusions: The simplicity of toluidine blue staining and its accuracy suggest that it can be a useful adjunctive tool to diagnosis of oral lesions. Results should be carefully evaluated and correlated with clinical findings and histopathological diagnosis.

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Section: Discussioncontrasting

confidence: 99%

The study of use of toluidine blue as an adjunctive tool to clinical examination in early diagnosis of clinically suspicious oral premalignant and malignant lesions: a study of fifty cases

Bayad

Bhagat

Sahni

et al. 2019

Int J Otorhinolaryngol Head Neck Surg

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“…This different appearance is caused by the differences in backscattering light between normal mucosa and abnormal lesions ( Figure 1). From all reports o'n chemiluminescent light systems published from 2007 to 2018, the sensitivity and specificity for the detection of OSCC and OPMDs were determined ranging between 0-100% and 0-27.8%, respectively [18][19][20][21][22][23][24][25][26]. Most reports demonstrated that the sensitivity for the detection of OSCC and OED was more than 70%.…”

Section: Examination Under Chemiluminescent Illuminationmentioning

confidence: 99%

Non-Invasive Diagnostic System Based on Light for Detecting Early-Stage Oral Cancer and High-Risk Precancerous Lesions—Potential for Dentistry

Tatehara

Satomura

2020

Cancers

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Oral health promotion and examinations have contributed to the early detection of oral cancer and oral potentially malignant disorders, leading to the adaptation of minimally invasive therapies and subsequent improvements in the prognosis/maintenance of the quality of life after treatments. However, the accurate detection of early-stage oral cancer and oral epithelial dysplasia is particularly difficult for conventional oral examinations because these lesions sometimes resemble benign lesions or healthy oral mucosa tissues. Although oral biopsy has been considered the gold standard for accurate diagnosis, it is deemed invasive for patients. For this reason, most clinicians are looking forward to the development of non-invasive diagnostic technologies to detect and distinguish between cancerous and benign lesions. To date, several non-invasive adjunctive fluorescence-based detection systems have improved the accuracy of the detection and diagnosis of oral mucosal lesions. Autofluorescence-based systems can detect lesions as a loss of autofluorescence through irradiation with blue-violet lights. Photodynamic diagnosis using 5-aminolevulinic acid (ALA-PDD) shows the presence of very early oral cancers and oral epithelial dysplasia as a red fluorescent area. In this article, currently used fluorescence-based diagnostic methods are introduced and discussed from a clinical point of view.

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“…On the contrary, ViziLite ® PLUS does not seems to be useful to detect malignancies in patients with clearly visible lesions ( Mojsa et al, 2012 ). In fact, some authors described the better diagnostic accuracy of ViziLite ® with respect to TB staining alone ( Rajmohan et al, 2012 ; Vashisht et al, 2014 ), justifying the combined use of these two techniques.…”

Section: Vizilite ®mentioning

confidence: 99%

An Overview on Current Non-invasive Diagnostic Devices in Oral Oncology

et al. 2018

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Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy, and despite advances in cancer therapies, the overall 5-year survival rate has remained below 50% over the past decades. OSCC is typically preceded by potentially malignant disorders (PMD), but distinguishing high-risk from low-risk PMD is challenging. In the last years, several diagnostic methods as light-based detection systems (LBDS) have been proposed to facilitate the detection of OSCC and PMD. Furthermore, the recent evolution of nanotechnology may provide new opportunities to detect PMD and OSCC at an early stage. Indeed, several preclinical studies showed the potential of nanotechnology to enhance diagnostic accuracy. For these reasons, it is fundamental to conduct studies to evaluate the efficacy of nanotechnology implementation in LBDS. The aim of this article is to review the current literature on LBDS and to provide a summary of the sensitivity and specificity of each technique, and possible future applications of nanotechnologies. The LBDS showed great potential for screening and monitoring oral lesions, but there are several factors that hinder an extensive use of these devices. These devices seem to be useful in assessing lesion margins that must be biopsied. However, to date, conventional oral examination, and tissue biopsy remain the gold standard for OSCC diagnosis. The use of nanotechnologies could be the next step in the evolution of LBDS, thus providing devices that can help clinicians to detect and better monitor oral lesions.

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Chemiluminescence and Toluidine Blue as Diagnostic Tools for Detecting Early Stages of Oral Cancer: An invivo Study

Cited by 20 publications

References 21 publications

The study of use of toluidine blue as an adjunctive tool to clinical examination in early diagnosis of clinically suspicious oral premalignant and malignant lesions: a study of fifty cases

The study of use of toluidine blue as an adjunctive tool to clinical examination in early diagnosis of clinically suspicious oral premalignant and malignant lesions: a study of fifty cases

Non-Invasive Diagnostic System Based on Light for Detecting Early-Stage Oral Cancer and High-Risk Precancerous Lesions—Potential for Dentistry

An Overview on Current Non-invasive Diagnostic Devices in Oral Oncology

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