ChemInform Abstract: 1,3‐Dipolar Cycloaddition Reaction Applied to Synthesis of New Unsymmetric Liquid Crystal Compounds‐Based Isoxazole.

Abstract

Isoxazole derivatives R 0240 1,3-Dipolar Cycloaddition Reaction Applied to Synthesis of New Unsymmetric Liquid Crystal Compounds-Based Isoxazole. -A simple method allows the regioselective preparation of unsymmetrically 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition of nitrile oxides. A second series containing a triple bond is obtained from the bromophenyl derivative (V) by Sonogashira cross-coupling. -(VIEIRA, A. A.; BRYK, F. R.; CONTE, G.; BORTOLUZZI, A. J.; GALLARDO*, H.; Tetrahedron Lett. 50 (2009) 8, 905-908; Dep. Quim., Univ. Fed. Santa Catarina, 88049 Florianopolis, Santa Catarina, Brazil; Eng.) -Mais 21-126