ChemInform Abstract: A Convenient Synthesis of Highly Substituted 3‐N,N‐Dialkylamino‐1,2,4‐triazoles.

Abstract

Triazole derivatives R 0280A Convenient Synthesis of Highly Substituted 3-N,N-Dialkylamino-1,2,4-triazoles. -Refined conditions A) or B) are developed for the synthesis of title compounds from isothioureas and acyl hydrazides. The process tolerates a variety of sensitive functional groups. -(BATCHELOR, D. V.; BEAL, D. M.; BROWN, T. B.; ELLIS, D.; GORDON, D. W.; JOHNSON, P. S.; MASON, H. J.; RALPH, M. J.; UNDERWOOD, T. J.; WHEELER*, S.; Synlett 2008, 16, 2421-2424; Sandwich Lab., Pfizer Global Res. Dev., Sandwich, Kent CT13 9NJ, UK; Eng.) -Mais 05-133