ChemInform Abstract: A Convergent, Modular Approach to Functionalized 2,1‐Borazaronaphthalenes from 2‐Aminostyrenes and Potassium Organotrifluoroborates.

Abstract

A Convergent, Modular Approach to Functionalized 2,1-Borazaronaphthalenes from 2-Aminostyrenes and Potassium Organotrifluoroborates. -A convergent approach is developed to synthesize disubstituted 2,1-borazaronaphthalenes from N-substituted 2-aminostyrenes and potassium organotrifluoroborates, where the potassium organotrifluoroborate is converted to the active R-BX 2 species (X = Cl or F) in situ by addition of a fluorophile. Using this method, a library of highly functionalized 2,1-borazaronaphthalenes are synthesized in one step under mild, transition-metal-free conditions. -(WISNIEWSKI, S. R.; GUENTHER, C. L.; ARGINTARU, O. A.; MOLANDER*, G. A.; J. Org. Chem. 79 (2014) 1, 365-378, http://dx.