ChemInform Abstract: A Facile Synthesis of N‐Carbamoylamino Acids.

Abstract

Peptides U 0400A Facile Synthesis of N-Carbamoylamino Acids. -Alkylation of mono-N-substituted parabanic acids followed by hydrolysis of the dialkylated intermediate provides the required druglike urea products which represent peptide analogues. The products are obtained in good to excellent yields with high purity and the method can be applied to the preparation of combinatorial libraries. -(BOGOLUBSKY, A. V.; RYABUKHIN*, S. V.; PAKHOMOV, G. G.; OSTAPCHUK, E. N.; SHIVANYUK, A. N.; TOLMACHEV, A. A.; Synlett 2008, 15, 2279-2282; Enamine Ltd., Kiev 01103, Ukraine; Eng.) -Lindner 04-181