ChemInform Abstract: A Facile Transfer of Dicyanomethylene Group Between Arylidenemalononitrile and Aldehyde.

Abstract

A Facile Transfer of Dicyanomethylene Group Between Arylidenemalononitrile and Aldehyde.-Arylidenemalononitriles (II) undergo facile exchange of dicyanomethylene group with β-formyl steroidal enamide (I) as well as aromatic aldehydes (IV) under mild base catalyzed conditions. -(AHMED, S.; SARMAH, U.; LONGCHAR, M.; BORUAH, R. C.; SANDHU, J.

I2-Mediated Oxidative C–N Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from α,β-Unsaturated Aldehydes/Ketones and Hydrazines

“…In light of these encouraging results, we initiated further investigation of this one-pot protocol with α,β-unsaturated ketones (Table ). It is noteworthy to mention that the condensation products of these enones and hydrazines are relatively less stable (decomposing in silica gel column, usually purified through recrystallization), which will decrease the overall efficiency of pyrazole synthesis via step-by-step reaction.…”