ChemInform Abstract: A New Approach for the Synthesis of Some Benzoxazinone and Quinazolinone Derivatives.

Abstract

A New Approach for the Synthesis of Some Benzoxazinone and Quinazolinone Derivatives. -The synthesis of benzoxazinones (III) and reactions with hydrazines, aliphatic and aromatic amines, ammonia, Grignard reagents and aromatic hydrocarbons are described. Most of the synthesized compounds are tested against different types of bacteria and some are strongly to moderately active. -(SOLIMAN, F. M.; ISLAM, I. E.; KASSAB, R. R.; SOUKA, L. M.; EL KADY, M. Y.; Rev. Roum. Chim. 39 (1994) 4, 405-411;

Synthesis and Biological Activity of Some New Substituted Quinazolin-4(3H)-Ones

“…3-(4-aminophenyl) -2 -benzyl -4 -oxo -3, 4-dihydroquinazoline″1a″ and 3-(4-aminophenyl) -2 -benzyl -6 -bromo -4 -oxo -3, 4-dihydroquinazoline ″1b″ were prepared according to the literature procedures (18)(19)(20) . These derivatives which bear a bulky substituent at position-2 (14,16). (c.f.…”