ChemInform Abstract: A New Cascade Radical Reaction for the Synthesis of Biaryls and Triaryls from Benzyl Iodoaryl Ethers.

Abstract

A New Cascade Radical Reaction for the Synthesis of Biaryls and Triaryls from Benzyl Iodoaryl Ethers.-A new method for the synthesis of biaryls and triaryls through an intramolecular ipso-substitution reaction initiated by the addition of an aryl radical to benzyl ether is developed. The method is applied to a tandem variant [→(VI)] and to the synthesis of the natural product isoaucuparin (IX). -(HARROWVEN, DAVID C.; NUNN, MICHAEL I. T.; NEWMAN, NICOLA A.; FENWICK, DAVID R.; Tetrahedron Lett. 42 (2001) 5, 961-964; Dep. Chem., Univ. Southampton, Southampton SO17 1BJ, UK; EN)