ChemInform Abstract: A New Method for Aromatic Difluoromethylation: Copper‐Catalyzed Cross‐Coupling and Decarboxylation Sequence from Aryl Iodides.

Abstract

A wide range of aryl iodides is coupled with silanes (I) or (IV) in the presence of CuI. Hydrolysis of the ester function according to A) followed by decarboxylation in the presence of KF or CsF produces the difluoromethyl analogues. Only in the case of (IIIg) no reaction takes place. -(FUJIKAWA, K.; FUJIOKA, Y.; KOBAYASHI, A.; AMII*, H.; Org. Lett. 13 (2011) 20, 5560-5563, http://dx.doi.org/10.1021/ol202289z ; Dep. Chem., Grad. Sch. Sci., Kobe Univ., Nada, Kobe 657, Japan; Eng.) -H. Simon 06-055